Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Dong, Z., Yang, N., Yeo, S., Chitnis, A., & Guo, S. Neuron, 74(1):65–78, April, 2012. Publisher: Elsevier Inc.![Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Asymmetric division of progenitor/stem cells generates both self-renewing and differentiating progeny and is fundamental to development and regeneration. How this process is regulated in the vertebrate brain remains incompletely understood. Here, we use time-lapse imaging to track radial glia progenitor behavior in the developing zebrafish brain. We find that asymmetric division invariably generates a basal self-renewing daughter and an apical differentiating sibling. Gene expression and genetic mosaic analysis further show that the apical daughter is the source of Notch ligand that is essential to maintain higher Notch activity in the basal daughter. Notably, establishment of this intralineage and directional Notch signaling requires the intrinsic polarity regulator Partitioning defective protein-3 (Par-3), which segregates the fate determinant Mind bomb unequally to the apical daughter, thereby restricting the self-renewal potential to the basal daughter. These findings reveal with single-cell resolution how self-renewal and differentiation become precisely segregated within asymmetrically dividing neural progenitor/stem lineages.
@article{Dong2012,
title = {Intralineage directional {Notch} signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia.},
volume = {74},
issn = {1097-4199},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3466114&tool=pmcentrez&rendertype=abstract},
doi = {10.1016/j.neuron.2012.01.031},
abstract = {Asymmetric division of progenitor/stem cells generates both self-renewing and differentiating progeny and is fundamental to development and regeneration. How this process is regulated in the vertebrate brain remains incompletely understood. Here, we use time-lapse imaging to track radial glia progenitor behavior in the developing zebrafish brain. We find that asymmetric division invariably generates a basal self-renewing daughter and an apical differentiating sibling. Gene expression and genetic mosaic analysis further show that the apical daughter is the source of Notch ligand that is essential to maintain higher Notch activity in the basal daughter. Notably, establishment of this intralineage and directional Notch signaling requires the intrinsic polarity regulator Partitioning defective protein-3 (Par-3), which segregates the fate determinant Mind bomb unequally to the apical daughter, thereby restricting the self-renewal potential to the basal daughter. These findings reveal with single-cell resolution how self-renewal and differentiation become precisely segregated within asymmetrically dividing neural progenitor/stem lineages.},
number = {1},
urldate = {2013-08-26},
journal = {Neuron},
author = {Dong, Zhiqiang and Yang, Nan and Yeo, Sang-Yeob and Chitnis, Ajay and Guo, Su},
month = apr,
year = {2012},
pmid = {22500631},
note = {Publisher: Elsevier Inc.},
keywords = {\#nosource, Animals, Asymmetric Cell Division, Asymmetric Cell Division: physiology, Cell Lineage, Cell Polarity, Embryo, Nonmammalian, Gene Expression Profiling, Neurogenesis, Neurogenesis: physiology, Neuroglia, Neuroglia: cytology, Neuroglia: physiology, Prosencephalon, Prosencephalon: cytology, Prosencephalon: embryology, Receptors, Notch, Receptors, Notch: metabolism, Signal Transduction, Signal Transduction: physiology, Stem Cells, Stem Cells: cytology, Stem Cells: physiology, Ubiquitin-Protein Ligases, Ubiquitin-Protein Ligases: physiology, Zebrafish, Zebrafish Proteins, Zebrafish Proteins: physiology},
pages = {65--78},
}
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