@article{RN209,
   author = {Drenthen, G. S. and Backes, W. H. and Rouhl, R. P. W. and Vlooswijk, M. C. G. and Majoie, Mhjm and Hofman, P. A. M. and Aldenkamp, A. P. and Jansen, J. F. A.},
   title = {Structural covariance networks relate to the severity of epilepsy with focal-onset seizures},
   journal = {Neuroimage Clin},
   volume = {20},
   pages = {861-867},
   note = {Drenthen, Gerhard S
Backes, Walter H
Rouhl, Rob P W
Vlooswijk, Marielle C G
Majoie, Marian H J M
Hofman, Paul A M
Aldenkamp, Albert P
Jansen, Jacobus F A
eng
Research Support, Non-U.S. Gov't
Netherlands
2018/10/03 06:00
Neuroimage Clin. 2018;20:861-867. doi: 10.1016/j.nicl.2018.09.023. Epub 2018 Sep 26.},
   abstract = {PURPOSE: The brains of patients with epilepsy may exhibit various morphological abnormalities, which are often not directly visible on structural MR images, as they may be focally subtle or related to a more large-scale inconspicuous disorganization of brain structures. To explore the relation between structural brain organization and epilepsy characteristics, including severity and cognitive co-morbidity, we determined structural covariance networks (SCNs). SCNs represent interregional correlations of morphologic measures, for instance in terms of cortical thickness, between various large-scale distributed brain regions. METHODS: Thirty-eight patients with focal seizures of all subtypes and 21 healthy controls underwent structural MRI, neurological, and IQ assessment. Cortical thickness was derived from the structural MRIs using FreeSurfer. Subsequently, SCNs were constructed on a group-level based on correlations of the cortical thicknesses between various brain regions. Individual SCNs for the epilepsy patients were extracted by adding the respective patient to the control group prior to the SCN construction (i.e. add-one-patient approach). Calculated network measures, i.e. path length, clustering coefficient and betweenness centrality were correlated with characteristics related to the severity of epilepsy, including seizure history and age at onset of epilepsy, and cognitive performance. RESULTS: Stronger clustering in the individual SCN was associated with a higher number of focal to bilateral tonic-clonic seizures during life time, a younger age at onset, and lower cognitive performance. The path length of the individual SCN was not related to the severity of epilepsy or cognitive performance. Higher betweenness centrality of the left cuneus and lower betweenness centrality of the right rostral middle frontal gyrus were associated with increased drug load and younger age at onset, respectively. CONCLUSIONS: These results indicate that the correlations between interregional variations of cortical thickness reflect disease characteristics or responses to the disease and deficits in patients with epilepsy with focal seizures.},
   keywords = {Adult
Brain/*diagnostic imaging/pathology
Data Interpretation, Statistical
Epilepsy/complications/*diagnostic imaging/pathology
Female
Humans
Image Processing, Computer-Assisted/*methods
Magnetic Resonance Imaging/methods
Male
Middle Aged
Neural Pathways
Neuropsychological Tests
Seizures/*diagnostic imaging/etiology/pathology
Severity of Illness Index
*Cognition
*Cortical thickness
*Epilepsy
*Magnetic resonance imaging
*Seizures
*Structural covarience networks},
   ISSN = {2213-1582 (Electronic)
2213-1582 (Linking)},
   DOI = {10.1016/j.nicl.2018.09.023},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/30278373
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169103/pdf/main.pdf},
   year = {2018},
   type = {Journal Article}
}

{"_id":"6TpnkzomepyNbZNMN","bibbaseid":"drenthen-backes-rouhl-vlooswijk-majoie-hofman-aldenkamp-jansen-structuralcovariancenetworksrelatetotheseverityofepilepsywithfocalonsetseizures-2018","downloads":0,"creationDate":"2018-10-18T19:36:02.895Z","title":"Structural covariance networks relate to the severity of epilepsy with focal-onset seizures","author_short":["Drenthen, G. S.","Backes, W. H.","Rouhl, R. P. W.","Vlooswijk, M. C. G.","Majoie, M.","Hofman, P. A. M.","Aldenkamp, A. P.","Jansen, J. F. A."],"year":2018,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Drenthen"],"firstnames":["G.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Rouhl"],"firstnames":["R.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Majoie"],"firstnames":["Mhjm"],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"Structural covariance networks relate to the severity of epilepsy with focal-onset seizures","journal":"Neuroimage Clin","volume":"20","pages":"861-867","note":"Drenthen, Gerhard S Backes, Walter H Rouhl, Rob P W Vlooswijk, Marielle C G Majoie, Marian H J M Hofman, Paul A M Aldenkamp, Albert P Jansen, Jacobus F A eng Research Support, Non-U.S. Gov't Netherlands 2018/10/03 06:00 Neuroimage Clin. 2018;20:861-867. doi: 10.1016/j.nicl.2018.09.023. Epub 2018 Sep 26.","abstract":"PURPOSE: The brains of patients with epilepsy may exhibit various morphological abnormalities, which are often not directly visible on structural MR images, as they may be focally subtle or related to a more large-scale inconspicuous disorganization of brain structures. To explore the relation between structural brain organization and epilepsy characteristics, including severity and cognitive co-morbidity, we determined structural covariance networks (SCNs). SCNs represent interregional correlations of morphologic measures, for instance in terms of cortical thickness, between various large-scale distributed brain regions. METHODS: Thirty-eight patients with focal seizures of all subtypes and 21 healthy controls underwent structural MRI, neurological, and IQ assessment. Cortical thickness was derived from the structural MRIs using FreeSurfer. Subsequently, SCNs were constructed on a group-level based on correlations of the cortical thicknesses between various brain regions. Individual SCNs for the epilepsy patients were extracted by adding the respective patient to the control group prior to the SCN construction (i.e. add-one-patient approach). Calculated network measures, i.e. path length, clustering coefficient and betweenness centrality were correlated with characteristics related to the severity of epilepsy, including seizure history and age at onset of epilepsy, and cognitive performance. RESULTS: Stronger clustering in the individual SCN was associated with a higher number of focal to bilateral tonic-clonic seizures during life time, a younger age at onset, and lower cognitive performance. The path length of the individual SCN was not related to the severity of epilepsy or cognitive performance. Higher betweenness centrality of the left cuneus and lower betweenness centrality of the right rostral middle frontal gyrus were associated with increased drug load and younger age at onset, respectively. CONCLUSIONS: These results indicate that the correlations between interregional variations of cortical thickness reflect disease characteristics or responses to the disease and deficits in patients with epilepsy with focal seizures.","keywords":"Adult Brain/*diagnostic imaging/pathology Data Interpretation, Statistical Epilepsy/complications/*diagnostic imaging/pathology Female Humans Image Processing, Computer-Assisted/*methods Magnetic Resonance Imaging/methods Male Middle Aged Neural Pathways Neuropsychological Tests Seizures/*diagnostic imaging/etiology/pathology Severity of Illness Index *Cognition *Cortical thickness *Epilepsy *Magnetic resonance imaging *Seizures *Structural covarience networks","issn":"2213-1582 (Electronic) 2213-1582 (Linking)","doi":"10.1016/j.nicl.2018.09.023","url":"http://www.ncbi.nlm.nih.gov/pubmed/30278373 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169103/pdf/main.pdf","year":"2018","bibtex":"@article{RN209,\n author = {Drenthen, G. S. and Backes, W. H. and Rouhl, R. P. W. and Vlooswijk, M. C. G. and Majoie, Mhjm and Hofman, P. A. M. and Aldenkamp, A. P. and Jansen, J. F. A.},\n title = {Structural covariance networks relate to the severity of epilepsy with focal-onset seizures},\n journal = {Neuroimage Clin},\n volume = {20},\n pages = {861-867},\n note = {Drenthen, Gerhard S\nBackes, Walter H\nRouhl, Rob P W\nVlooswijk, Marielle C G\nMajoie, Marian H J M\nHofman, Paul A M\nAldenkamp, Albert P\nJansen, Jacobus F A\neng\nResearch Support, Non-U.S. Gov't\nNetherlands\n2018/10/03 06:00\nNeuroimage Clin. 2018;20:861-867. doi: 10.1016/j.nicl.2018.09.023. Epub 2018 Sep 26.},\n abstract = {PURPOSE: The brains of patients with epilepsy may exhibit various morphological abnormalities, which are often not directly visible on structural MR images, as they may be focally subtle or related to a more large-scale inconspicuous disorganization of brain structures. To explore the relation between structural brain organization and epilepsy characteristics, including severity and cognitive co-morbidity, we determined structural covariance networks (SCNs). SCNs represent interregional correlations of morphologic measures, for instance in terms of cortical thickness, between various large-scale distributed brain regions. METHODS: Thirty-eight patients with focal seizures of all subtypes and 21 healthy controls underwent structural MRI, neurological, and IQ assessment. Cortical thickness was derived from the structural MRIs using FreeSurfer. Subsequently, SCNs were constructed on a group-level based on correlations of the cortical thicknesses between various brain regions. Individual SCNs for the epilepsy patients were extracted by adding the respective patient to the control group prior to the SCN construction (i.e. add-one-patient approach). Calculated network measures, i.e. path length, clustering coefficient and betweenness centrality were correlated with characteristics related to the severity of epilepsy, including seizure history and age at onset of epilepsy, and cognitive performance. RESULTS: Stronger clustering in the individual SCN was associated with a higher number of focal to bilateral tonic-clonic seizures during life time, a younger age at onset, and lower cognitive performance. The path length of the individual SCN was not related to the severity of epilepsy or cognitive performance. Higher betweenness centrality of the left cuneus and lower betweenness centrality of the right rostral middle frontal gyrus were associated with increased drug load and younger age at onset, respectively. CONCLUSIONS: These results indicate that the correlations between interregional variations of cortical thickness reflect disease characteristics or responses to the disease and deficits in patients with epilepsy with focal seizures.},\n keywords = {Adult\nBrain/*diagnostic imaging/pathology\nData Interpretation, Statistical\nEpilepsy/complications/*diagnostic imaging/pathology\nFemale\nHumans\nImage Processing, Computer-Assisted/*methods\nMagnetic Resonance Imaging/methods\nMale\nMiddle Aged\nNeural Pathways\nNeuropsychological Tests\nSeizures/*diagnostic imaging/etiology/pathology\nSeverity of Illness Index\n*Cognition\n*Cortical thickness\n*Epilepsy\n*Magnetic resonance imaging\n*Seizures\n*Structural covarience networks},\n ISSN = {2213-1582 (Electronic)\n2213-1582 (Linking)},\n DOI = {10.1016/j.nicl.2018.09.023},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/30278373\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169103/pdf/main.pdf},\n year = {2018},\n type = {Journal Article}\n}\n\n","author_short":["Drenthen, G. 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