@article{RN180,
   author = {Drenthen, G. S. and Barendse, E. M. and Aldenkamp, A. P. and van Veenendaal, T. M. and Puts, N. A. and Edden, R. A. and Zinger, S. and Thoonen, G. and Hendriks, M. P. and Kessels, R. P. and Jansen, J. F.},
   title = {Altered neurotransmitter metabolism in adolescents with high-functioning autism},
   journal = {Psychiatry Res Neuroimaging},
   volume = {256},
   pages = {44-49},
   note = {Drenthen, Gerhard S
Barendse, Evelien M
Aldenkamp, Albert P
van Veenendaal, Tamar M
Puts, Nicolaas A J
Edden, Richard A E
Zinger, Svitlana
Thoonen, Geert
Hendriks, Marc P H
Kessels, Roy P C
Jansen, Jacobus F A
eng
U54 HD079123/HD/NICHD NIH HHS/
R01 MH106564/MH/NIMH NIH HHS/
K99 MH107719/MH/NIMH NIH HHS/
R00 MH107719/MH/NIMH NIH HHS/
P41 EB015909/EB/NIBIB NIH HHS/
R01 EB016089/EB/NIBIB NIH HHS/
Netherlands
2016/09/30 06:00
Psychiatry Res Neuroimaging. 2016 Oct 30;256:44-49. doi: 10.1016/j.pscychresns.2016.09.007. Epub 2016 Sep 20.},
   abstract = {Previous studies have suggested that alterations in excitatory/inhibitory neurotransmitters might play a crucial role in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopy ((1)H-MRS) can provide valuable information about abnormal brain metabolism and neurotransmitter concentrations. However, few (1)H-MRS studies have been published on the imbalance of the two most abundant neurotransmitters in ASD: glutamate (Glu) and gamma-aminobutyric acid (GABA). Moreover, to our knowledge none of these published studies is performed with a study population consisting purely of high-functioning autism (HFA) adolescents. Selecting only individuals with HFA eliminates factors possibly related to intellectual impairment instead of ASD. This study aims to assess Glu and GABA neurotransmitter concentrations in HFA. Occipital concentrations of Glu and GABA plus macromolecules (GABA+) were obtained using (1)H-MRS relative to creatine (Cr) in adolescents with HFA (n=15 and n=13 respectively) and a healthy control group (n=17). Multiple linear regression revealed significantly higher Glu/Cr and lower GABA+/Glu concentrations in the HFA group compared to the controls. These results imply that imbalanced neurotransmitter levels of excitation and inhibition are associated with HFA in adolescents.},
   keywords = {Adolescent
Autism Spectrum Disorder/*metabolism
Creatine/metabolism
Female
Glutamic Acid/*metabolism
Humans
Magnetic Resonance Spectroscopy/methods
Male
Proton Magnetic Resonance Spectroscopy
gamma-Aminobutyric Acid/*metabolism
*Gamma-aminobutyric acid
*Glutamate
*Magnetic resonance spectroscopy},
   ISSN = {1872-7506 (Electronic)
0925-4927 (Linking)},
   DOI = {10.1016/j.pscychresns.2016.09.007},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/27685800
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385138/pdf/nihms854039.pdf},
   year = {2016},
   type = {Journal Article}
}

{"_id":"DmAA4w7BuaY3wHJLW","bibbaseid":"drenthen-barendse-aldenkamp-vanveenendaal-puts-edden-zinger-thoonen-etal-alteredneurotransmittermetabolisminadolescentswithhighfunctioningautism-2016","downloads":0,"creationDate":"2017-09-02T16:45:18.642Z","title":"Altered neurotransmitter metabolism in adolescents with high-functioning autism","author_short":["Drenthen, G. S.","Barendse, E. M.","Aldenkamp, A. P.","van Veenendaal, T. M.","Puts, N. A.","Edden, R. A.","Zinger, S.","Thoonen, G.","Hendriks, M. P.","Kessels, R. P.","Jansen, J. F."],"year":2016,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Drenthen"],"firstnames":["G.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Barendse"],"firstnames":["E.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":["van"],"lastnames":["Veenendaal"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Puts"],"firstnames":["N.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Edden"],"firstnames":["R.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Zinger"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Thoonen"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Hendriks"],"firstnames":["M.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Kessels"],"firstnames":["R.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]}],"title":"Altered neurotransmitter metabolism in adolescents with high-functioning autism","journal":"Psychiatry Res Neuroimaging","volume":"256","pages":"44-49","note":"Drenthen, Gerhard S Barendse, Evelien M Aldenkamp, Albert P van Veenendaal, Tamar M Puts, Nicolaas A J Edden, Richard A E Zinger, Svitlana Thoonen, Geert Hendriks, Marc P H Kessels, Roy P C Jansen, Jacobus F A eng U54 HD079123/HD/NICHD NIH HHS/ R01 MH106564/MH/NIMH NIH HHS/ K99 MH107719/MH/NIMH NIH HHS/ R00 MH107719/MH/NIMH NIH HHS/ P41 EB015909/EB/NIBIB NIH HHS/ R01 EB016089/EB/NIBIB NIH HHS/ Netherlands 2016/09/30 06:00 Psychiatry Res Neuroimaging. 2016 Oct 30;256:44-49. doi: 10.1016/j.pscychresns.2016.09.007. Epub 2016 Sep 20.","abstract":"Previous studies have suggested that alterations in excitatory/inhibitory neurotransmitters might play a crucial role in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopy ((1)H-MRS) can provide valuable information about abnormal brain metabolism and neurotransmitter concentrations. However, few (1)H-MRS studies have been published on the imbalance of the two most abundant neurotransmitters in ASD: glutamate (Glu) and gamma-aminobutyric acid (GABA). Moreover, to our knowledge none of these published studies is performed with a study population consisting purely of high-functioning autism (HFA) adolescents. Selecting only individuals with HFA eliminates factors possibly related to intellectual impairment instead of ASD. This study aims to assess Glu and GABA neurotransmitter concentrations in HFA. Occipital concentrations of Glu and GABA plus macromolecules (GABA+) were obtained using (1)H-MRS relative to creatine (Cr) in adolescents with HFA (n=15 and n=13 respectively) and a healthy control group (n=17). Multiple linear regression revealed significantly higher Glu/Cr and lower GABA+/Glu concentrations in the HFA group compared to the controls. These results imply that imbalanced neurotransmitter levels of excitation and inhibition are associated with HFA in adolescents.","keywords":"Adolescent Autism Spectrum Disorder/*metabolism Creatine/metabolism Female Glutamic Acid/*metabolism Humans Magnetic Resonance Spectroscopy/methods Male Proton Magnetic Resonance Spectroscopy gamma-Aminobutyric Acid/*metabolism *Gamma-aminobutyric acid *Glutamate *Magnetic resonance spectroscopy","issn":"1872-7506 (Electronic) 0925-4927 (Linking)","doi":"10.1016/j.pscychresns.2016.09.007","url":"http://www.ncbi.nlm.nih.gov/pubmed/27685800 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385138/pdf/nihms854039.pdf","year":"2016","bibtex":"@article{RN180,\n author = {Drenthen, G. S. and Barendse, E. M. and Aldenkamp, A. P. and van Veenendaal, T. M. and Puts, N. A. and Edden, R. A. and Zinger, S. and Thoonen, G. and Hendriks, M. P. and Kessels, R. P. and Jansen, J. F.},\n title = {Altered neurotransmitter metabolism in adolescents with high-functioning autism},\n journal = {Psychiatry Res Neuroimaging},\n volume = {256},\n pages = {44-49},\n note = {Drenthen, Gerhard S\nBarendse, Evelien M\nAldenkamp, Albert P\nvan Veenendaal, Tamar M\nPuts, Nicolaas A J\nEdden, Richard A E\nZinger, Svitlana\nThoonen, Geert\nHendriks, Marc P H\nKessels, Roy P C\nJansen, Jacobus F A\neng\nU54 HD079123/HD/NICHD NIH HHS/\nR01 MH106564/MH/NIMH NIH HHS/\nK99 MH107719/MH/NIMH NIH HHS/\nR00 MH107719/MH/NIMH NIH HHS/\nP41 EB015909/EB/NIBIB NIH HHS/\nR01 EB016089/EB/NIBIB NIH HHS/\nNetherlands\n2016/09/30 06:00\nPsychiatry Res Neuroimaging. 2016 Oct 30;256:44-49. doi: 10.1016/j.pscychresns.2016.09.007. Epub 2016 Sep 20.},\n abstract = {Previous studies have suggested that alterations in excitatory/inhibitory neurotransmitters might play a crucial role in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopy ((1)H-MRS) can provide valuable information about abnormal brain metabolism and neurotransmitter concentrations. However, few (1)H-MRS studies have been published on the imbalance of the two most abundant neurotransmitters in ASD: glutamate (Glu) and gamma-aminobutyric acid (GABA). Moreover, to our knowledge none of these published studies is performed with a study population consisting purely of high-functioning autism (HFA) adolescents. Selecting only individuals with HFA eliminates factors possibly related to intellectual impairment instead of ASD. This study aims to assess Glu and GABA neurotransmitter concentrations in HFA. Occipital concentrations of Glu and GABA plus macromolecules (GABA+) were obtained using (1)H-MRS relative to creatine (Cr) in adolescents with HFA (n=15 and n=13 respectively) and a healthy control group (n=17). Multiple linear regression revealed significantly higher Glu/Cr and lower GABA+/Glu concentrations in the HFA group compared to the controls. These results imply that imbalanced neurotransmitter levels of excitation and inhibition are associated with HFA in adolescents.},\n keywords = {Adolescent\nAutism Spectrum Disorder/*metabolism\nCreatine/metabolism\nFemale\nGlutamic Acid/*metabolism\nHumans\nMagnetic Resonance Spectroscopy/methods\nMale\nProton Magnetic Resonance Spectroscopy\ngamma-Aminobutyric Acid/*metabolism\n*Gamma-aminobutyric acid\n*Glutamate\n*Magnetic resonance spectroscopy},\n ISSN = {1872-7506 (Electronic)\n0925-4927 (Linking)},\n DOI = {10.1016/j.pscychresns.2016.09.007},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/27685800\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385138/pdf/nihms854039.pdf},\n year = {2016},\n type = {Journal Article}\n}\n\n","author_short":["Drenthen, G. S.","Barendse, E. M.","Aldenkamp, A. P.","van Veenendaal, T. M.","Puts, N. A.","Edden, R. 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