Constructing an Axonal-Specific Myelin Developmental Graph and its Application to Childhood Absence Epilepsy. Drenthen, G. S., Fonseca Wald, E. L. A., Backes, W. H., Aldenkamp, A. P., Vermeulen, R. J., Debeij-van Hall, M. H., Klinkenberg, S., & Jansen, J. F. A. J Neuroimaging, 2020. Drenthen, Gerhard S Fonseca Wald, Eric L A Backes, Walter H Aldenkamp, Albert P Vermeulen, R Jeroen Debeij-van Hall, Mariette H J A Klinkenberg, Sylvia Jansen, Jacobus F A eng 2020/04/08 06:00 J Neuroimaging. 2020 Apr 7. doi: 10.1111/jon.12707.
Constructing an Axonal-Specific Myelin Developmental Graph and its Application to Childhood Absence Epilepsy [link]Paper  doi  abstract   bibtex   
BACKGROUND AND PURPOSE: The process of myelination starts in utero around 20 weeks of gestation and continues through adulthood. We first set out to characterize the maturation of the tract-specific myelin content in healthy subjects from childhood (7-12 years) into adulthood (18-32 years). Second, we apply the resulting development graph to children with childhood absence epilepsy (CAE), a pediatric epilepsy that was previously characterized by changes in myelin content. METHODS: In a prospective cross-sectional study, 15 healthy children (7-12 years), 14 healthy adult participants (18-32 years) and 17 children with a clinical diagnosis of CAE (6-12 years) were included. For each participant, diffusion weighted images were acquired to reconstruct bundles of white matter tracts and multi-echo multi-slice GRASE images were acquired for myelin-water estimation. Subsequently, a tract-specific myelin development graph was constructed using the percentual difference in myelin-water content from childhood (12 year) to adulthood (25 year). RESULTS: The graph revealed myelination patterns, where tracts in the central regions myelinate prior to peripheral tracts and intra-hemispheric tracts as well as tracts in the left hemisphere myelinate prior to inter-hemispheric tracts and tracts in the right hemisphere, respectively. No significant differences were found in myelin-water content between children with CAE and healthy children for neither the early developing tracts, nor the tracts that develop in a later stage. However, the difference between the myelin-water of late and early developing tracts is significantly smaller in the children with CAE. CONCLUSION: These results indicate that CAE is associated with widespread neurodevelopmental myelin differences.
@article{RN246,
   author = {Drenthen, G. S. and Fonseca Wald, E. L. A. and Backes, W. H. and Aldenkamp, A. P. and Vermeulen, R. J. and Debeij-van Hall, M. H. and Klinkenberg, S. and Jansen, J. F. A.},
   title = {Constructing an Axonal-Specific Myelin Developmental Graph and its Application to Childhood Absence Epilepsy},
   journal = {J Neuroimaging},
   note = {Drenthen, Gerhard S
Fonseca Wald, Eric L A
Backes, Walter H
Aldenkamp, Albert P
Vermeulen, R Jeroen
Debeij-van Hall, Mariette H J A
Klinkenberg, Sylvia
Jansen, Jacobus F A
eng
2020/04/08 06:00
J Neuroimaging. 2020 Apr 7. doi: 10.1111/jon.12707.},
   abstract = {BACKGROUND AND PURPOSE: The process of myelination starts in utero around 20 weeks of gestation and continues through adulthood. We first set out to characterize the maturation of the tract-specific myelin content in healthy subjects from childhood (7-12 years) into adulthood (18-32 years). Second, we apply the resulting development graph to children with childhood absence epilepsy (CAE), a pediatric epilepsy that was previously characterized by changes in myelin content. METHODS: In a prospective cross-sectional study, 15 healthy children (7-12 years), 14 healthy adult participants (18-32 years) and 17 children with a clinical diagnosis of CAE (6-12 years) were included. For each participant, diffusion weighted images were acquired to reconstruct bundles of white matter tracts and multi-echo multi-slice GRASE images were acquired for myelin-water estimation. Subsequently, a tract-specific myelin development graph was constructed using the percentual difference in myelin-water content from childhood (12 year) to adulthood (25 year). RESULTS: The graph revealed myelination patterns, where tracts in the central regions myelinate prior to peripheral tracts and intra-hemispheric tracts as well as tracts in the left hemisphere myelinate prior to inter-hemispheric tracts and tracts in the right hemisphere, respectively. No significant differences were found in myelin-water content between children with CAE and healthy children for neither the early developing tracts, nor the tracts that develop in a later stage. However, the difference between the myelin-water of late and early developing tracts is significantly smaller in the children with CAE. CONCLUSION: These results indicate that CAE is associated with widespread neurodevelopmental myelin differences.},
   keywords = {Maturation
diffusion MRI
myelin-water
tractography
white matter},
   ISSN = {1552-6569 (Electronic)
1051-2284 (Linking)},
   DOI = {10.1111/jon.12707},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/32255537
https://onlinelibrary.wiley.com/doi/full/10.1111/jon.12707},
   year = {2020},
   type = {Journal Article}
}
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