@article{RN221,
   author = {Drenthen, G. S. and Fonseca Wald, E. L. A. and Backes, W. H. and Debeij-Van Hall, Mhja and Hendriksen, J. G. M. and Aldenkamp, A. P. and Vermeulen, R. J. and Klinkenberg, S. and Jansen, J. F. A.},
   title = {Lower myelin-water content of the frontal lobe in childhood absence epilepsy},
   journal = {Epilepsia},
   volume = {60},
   number = {8},
   pages = {1689-1696},
   note = {Drenthen, Gerhard S
Fonseca Wald, Eric L A
Backes, Walter H
Debeij-Van Hall, Mariette H J A
Hendriksen, Jos G M
Aldenkamp, Albert P
Vermeulen, R Jeroen
Klinkenberg, Sylvia
Jansen, Jacobus F A
eng
Stichting Vooruit
2019/07/10 06:00
Epilepsia. 2019 Aug;60(8):1689-1696. doi: 10.1111/epi.16280. Epub 2019 Jul 8.},
   abstract = {OBJECTIVE: The frontal lobe in childhood absence epilepsy (CAE) might be affected due to the suggested involvement of the frontal lobe during absence seizures and reports on attentional deficits. Previously, subtle white matter abnormalities have been reported in CAE. However, the impact of one of the most characteristic components of the white matter, the myelin content, remains underdetermined. Therefore, this study investigated whether the myelin content in frontal areas is adversely affected in CAE compared to controls. METHODS: Seventeen children with childhood absence epilepsy (mean age +/- standard deviation [SD], 9.2 +/- 2.1 years) and 15 age- and sex-matched controls (mean age +/- SD, 9.8 +/- 1.8 years) underwent neuropsychological assessment and a magnetic resonance imaging (MRI) examination. T2 relaxometry scans were used to distinguish myelin-water from tissue water and to determine the myelin-water fraction (MWF) in the frontal, temporal, parietal, occipital, and insular lobes. A linear regression model including age and sex as covariates was used to investigate group differences. Furthermore, the relationship of MWF with cognitive performance and epilepsy characteristics was determined. RESULTS: The frontal lobe revealed a significantly lower myelin-water content in children with CAE compared to controls over the developmental age range of 6-12 years (5.7 +/- 1.0% vs 6.6 +/- 1.1%, P = 0.02). This association was not found for any of the other four lobes (P > 0.10). No significant relation was found between myelin-water content and cognitive performance or epilepsy characteristics. SIGNIFICANCE: The lower frontal myelin-water content of children with CAE in comparison with healthy controls probably reflects an altered neurodevelopmental aspect in CAE, of which the underlying mechanisms still need to be unraveled.},
   keywords = {myelin-water fraction
neurodevelopment
white matter},
   ISSN = {1528-1167 (Electronic)
0013-9580 (Linking)},
   DOI = {10.1111/epi.16280},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/31283841
https://onlinelibrary.wiley.com/doi/full/10.1111/epi.16280},
   year = {2019},
   type = {Journal Article}
}

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S.","Fonseca Wald, E. L. A.","Backes, W. H.","Debeij-Van Hall, M.","Hendriksen, J. G. M.","Aldenkamp, A. P.","Vermeulen, R. J.","Klinkenberg, S.","Jansen, J. F. A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Drenthen"],"firstnames":["G.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Fonseca","Wald"],"firstnames":["E.","L.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Debeij-Van","Hall"],"firstnames":["Mhja"],"suffixes":[]},{"propositions":[],"lastnames":["Hendriksen"],"firstnames":["J.","G.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Vermeulen"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Klinkenberg"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"Lower myelin-water content of the frontal lobe in childhood absence epilepsy","journal":"Epilepsia","volume":"60","number":"8","pages":"1689-1696","note":"Drenthen, Gerhard S Fonseca Wald, Eric L A Backes, Walter H Debeij-Van Hall, Mariette H J A Hendriksen, Jos G M Aldenkamp, Albert P Vermeulen, R Jeroen Klinkenberg, Sylvia Jansen, Jacobus F A eng Stichting Vooruit 2019/07/10 06:00 Epilepsia. 2019 Aug;60(8):1689-1696. doi: 10.1111/epi.16280. Epub 2019 Jul 8.","abstract":"OBJECTIVE: The frontal lobe in childhood absence epilepsy (CAE) might be affected due to the suggested involvement of the frontal lobe during absence seizures and reports on attentional deficits. Previously, subtle white matter abnormalities have been reported in CAE. However, the impact of one of the most characteristic components of the white matter, the myelin content, remains underdetermined. Therefore, this study investigated whether the myelin content in frontal areas is adversely affected in CAE compared to controls. METHODS: Seventeen children with childhood absence epilepsy (mean age +/- standard deviation [SD], 9.2 +/- 2.1 years) and 15 age- and sex-matched controls (mean age +/- SD, 9.8 +/- 1.8 years) underwent neuropsychological assessment and a magnetic resonance imaging (MRI) examination. T2 relaxometry scans were used to distinguish myelin-water from tissue water and to determine the myelin-water fraction (MWF) in the frontal, temporal, parietal, occipital, and insular lobes. A linear regression model including age and sex as covariates was used to investigate group differences. Furthermore, the relationship of MWF with cognitive performance and epilepsy characteristics was determined. RESULTS: The frontal lobe revealed a significantly lower myelin-water content in children with CAE compared to controls over the developmental age range of 6-12 years (5.7 +/- 1.0% vs 6.6 +/- 1.1%, P = 0.02). This association was not found for any of the other four lobes (P > 0.10). No significant relation was found between myelin-water content and cognitive performance or epilepsy characteristics. SIGNIFICANCE: The lower frontal myelin-water content of children with CAE in comparison with healthy controls probably reflects an altered neurodevelopmental aspect in CAE, of which the underlying mechanisms still need to be unraveled.","keywords":"myelin-water fraction neurodevelopment white matter","issn":"1528-1167 (Electronic) 0013-9580 (Linking)","doi":"10.1111/epi.16280","url":"http://www.ncbi.nlm.nih.gov/pubmed/31283841 https://onlinelibrary.wiley.com/doi/full/10.1111/epi.16280","year":"2019","bibtex":"@article{RN221,\n author = {Drenthen, G. S. and Fonseca Wald, E. L. A. and Backes, W. H. and Debeij-Van Hall, Mhja and Hendriksen, J. G. M. and Aldenkamp, A. P. and Vermeulen, R. J. and Klinkenberg, S. and Jansen, J. F. A.},\n title = {Lower myelin-water content of the frontal lobe in childhood absence epilepsy},\n journal = {Epilepsia},\n volume = {60},\n number = {8},\n pages = {1689-1696},\n note = {Drenthen, Gerhard S\nFonseca Wald, Eric L A\nBackes, Walter H\nDebeij-Van Hall, Mariette H J A\nHendriksen, Jos G M\nAldenkamp, Albert P\nVermeulen, R Jeroen\nKlinkenberg, Sylvia\nJansen, Jacobus F A\neng\nStichting Vooruit\n2019/07/10 06:00\nEpilepsia. 2019 Aug;60(8):1689-1696. doi: 10.1111/epi.16280. Epub 2019 Jul 8.},\n abstract = {OBJECTIVE: The frontal lobe in childhood absence epilepsy (CAE) might be affected due to the suggested involvement of the frontal lobe during absence seizures and reports on attentional deficits. Previously, subtle white matter abnormalities have been reported in CAE. However, the impact of one of the most characteristic components of the white matter, the myelin content, remains underdetermined. Therefore, this study investigated whether the myelin content in frontal areas is adversely affected in CAE compared to controls. METHODS: Seventeen children with childhood absence epilepsy (mean age +/- standard deviation [SD], 9.2 +/- 2.1 years) and 15 age- and sex-matched controls (mean age +/- SD, 9.8 +/- 1.8 years) underwent neuropsychological assessment and a magnetic resonance imaging (MRI) examination. T2 relaxometry scans were used to distinguish myelin-water from tissue water and to determine the myelin-water fraction (MWF) in the frontal, temporal, parietal, occipital, and insular lobes. A linear regression model including age and sex as covariates was used to investigate group differences. Furthermore, the relationship of MWF with cognitive performance and epilepsy characteristics was determined. RESULTS: The frontal lobe revealed a significantly lower myelin-water content in children with CAE compared to controls over the developmental age range of 6-12 years (5.7 +/- 1.0% vs 6.6 +/- 1.1%, P = 0.02). This association was not found for any of the other four lobes (P > 0.10). No significant relation was found between myelin-water content and cognitive performance or epilepsy characteristics. SIGNIFICANCE: The lower frontal myelin-water content of children with CAE in comparison with healthy controls probably reflects an altered neurodevelopmental aspect in CAE, of which the underlying mechanisms still need to be unraveled.},\n keywords = {myelin-water fraction\nneurodevelopment\nwhite matter},\n ISSN = {1528-1167 (Electronic)\n0013-9580 (Linking)},\n DOI = {10.1111/epi.16280},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/31283841\nhttps://onlinelibrary.wiley.com/doi/full/10.1111/epi.16280},\n year = {2019},\n type = {Journal Article}\n}\n\n","author_short":["Drenthen, G. 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