Acute postnatal exposure to the pentaBDE commercial mixture DE-71 at 5 or 15 mg/kg/day does not produce learning or attention deficits in rats. Driscoll, L. L, Kaplan, J., Bucuvalas, E., Allen, H., Kraut, J., & Fitzpatrick, J. Neurotoxicology and teratology, 34(1):20–6.
Acute postnatal exposure to the pentaBDE commercial mixture DE-71 at 5 or 15 mg/kg/day does not produce learning or attention deficits in rats. [link]Paper  doi  abstract   bibtex   
Polybrominated diphenyl ethers (PBDEs), flame retardant chemicals added to polymer products, have become ubiquitous in the environment, and they are bioaccumulating in humans and wildlife. Therefore, understanding their biological effects is important for public health. We have previously observed learning deficits in rats exposed to DE-71, a commercial PBDE mixture consisting primarily of pentabrominated diphenyl ethers, at a dose of 30 mg/kg/day from postnatal day (PND) 6 to 12. The purpose of the current study was to determine if this effect could be seen with lower doses of DE-71. Long-Evans rats were administered daily oral doses of corn oil alone or DE-71, 5 or 15 mg/kg/day, dissolved in corn oil, from PND 6 to 12. As young adults, the rats were administered a series of five-choice visual learning and attention tasks. No effects of DE-71 were found on learning, attention, or inhibitory control. Given that developmental DE-71 exposure at similar doses and for shorter time periods has been shown in other laboratories to affect locomotion and hyperactivity, the current results suggest that cognitive functions may not be as sensitive as neuromotor functions to the effects of acute DE-71 exposure.
@article{driscoll_acute_nodate,
	title = {Acute postnatal exposure to the {pentaBDE} commercial mixture {DE}-71 at 5 or 15 mg/kg/day does not produce learning or attention deficits in rats.},
	volume = {34},
	issn = {1872-9738},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22024237},
	doi = {10.1016/j.ntt.2011.10.002},
	abstract = {Polybrominated diphenyl ethers (PBDEs), flame retardant chemicals added to polymer products, have become ubiquitous in the environment, and they are bioaccumulating in humans and wildlife. Therefore, understanding their biological effects is important for public health. We have previously observed learning deficits in rats exposed to DE-71, a commercial PBDE mixture consisting primarily of pentabrominated diphenyl ethers, at a dose of 30 mg/kg/day from postnatal day (PND) 6 to 12. The purpose of the current study was to determine if this effect could be seen with lower doses of DE-71. Long-Evans rats were administered daily oral doses of corn oil alone or DE-71, 5 or 15 mg/kg/day, dissolved in corn oil, from PND 6 to 12. As young adults, the rats were administered a series of five-choice visual learning and attention tasks. No effects of DE-71 were found on learning, attention, or inhibitory control. Given that developmental DE-71 exposure at similar doses and for shorter time periods has been shown in other laboratories to affect locomotion and hyperactivity, the current results suggest that cognitive functions may not be as sensitive as neuromotor functions to the effects of acute DE-71 exposure.},
	number = {1},
	journal = {Neurotoxicology and teratology},
	author = {Driscoll, Lori L and Kaplan, Joshua and Bucuvalas, Eleni and Allen, Hunter and Kraut, Joshua and Fitzpatrick, Jesse},
	pmid = {22024237},
	keywords = {Acute Disease, Animal, Animals, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: che, Attention Deficit Disorder with Hyperactivity: dia, Attention Deficit Disorder with Hyperactivity: phy, Cognition Disorders, Cognition Disorders: chemically induced, Cognition Disorders: diagnosis, Cognition Disorders: physiopathology, Disease Models, Environmental Exposure, Environmental Exposure: adverse effects, Female, Flame Retardants: toxicity, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: toxicity, Learning Disorders, Learning Disorders: chemically induced, Learning Disorders: diagnosis, Learning Disorders: physiopathology, Long-Evans, Male, Newborn, Rats},
	pages = {20--6},
}

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