Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens. Dürschmid, S., Zaehle, T., Hinrichs, H., Heinze, H. J., Voges, J., Garrido, M. I., Dolan, R. J., & Knight, R. T. Cerebral Cortex, 26(3):1168–1175, March, 2016. doi abstract bibtex Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.
@article{durschmid_sensory_2016,
title = {Sensory {Deviancy} {Detection} {Measured} {Directly} {Within} the {Human} {Nucleus} {Accumbens}},
volume = {26},
doi = {10.1093/cercor/bhu304},
abstract = {Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.},
number = {3},
journal = {Cerebral Cortex},
author = {Dürschmid, S. and Zaehle, T. and Hinrichs, H. and Heinze, H. J. and Voges, J. and Garrido, M. I. and Dolan, R. J. and Knight, R. T.},
month = mar,
year = {2016},
pages = {1168--1175},
}
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