@article{du_vivo_2023,
	title = {In vivo visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices},
	volume = {14},
	issn = {2041-6520},
	doi = {10.1039/d2sc05897a},
	abstract = {The pathogenesis of Alzheimer's disease (AD) is closely related to several contributing factors, especially amyloid-beta (A beta) aggregation. Bioorthogonal reactions provide a general, facile, and robust route for the localization and derivatization of A beta-targeted agents. Herein, a pair of chiral alkyne-containing metallohelices (lambda A and \& UDelta;A) were demonstrated to enantioselectively target and modulate A beta aggregation, which has been monitored in triple-transgenic AD model mice and proved to improve cognitive function. Compared with its enantiomer \& UDelta;A, lambda A performed better in blocking A beta fibrillation, relieving A beta-triggered toxicity, and recovering memory deficits in vivo. Moreover, clickable lambda A could act as a functional module for subsequent visualization and versatile modification of amyloid via bioorthogonal reaction. As a proof-of-concept, thioflavin T, tacrine, and magnetic nanoparticles were conjugated with lambda A to realize A beta photo-oxygenation, acetylcholinesterase inhibition, and A beta clearance, respectively. This proof-of-principle work provided new insights into the biolabeling and bioconjugation of multifunctional metallosupramolecules through click reactions for AD therapy.},
	number = {3},
	urldate = {2022-12-22},
	journal = {CHEMICAL SCIENCE},
	author = {Du, Zhi and Liu, Chun and Liu, Zhenqi and Song, Hualong and Scott, Peter and Du, Xiubo and Ren, Jinsong and Qu, Xiaogang},
	month = jan,
	year = {2023},
	pages = {506--513},
}

{"_id":"okyqmn8SwpFbnqa2n","bibbaseid":"du-liu-liu-song-scott-du-ren-qu-invivovisualizationofenantioselectivetargetingofamyloidandimprovementofcognitivefunctionbyclickablechiralmetallohelices-2023","author_short":["Du, Z.","Liu, C.","Liu, Z.","Song, H.","Scott, P.","Du, X.","Ren, J.","Qu, X."],"bibdata":{"bibtype":"article","type":"article","title":"In vivo visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices","volume":"14","issn":"2041-6520","doi":"10.1039/d2sc05897a","abstract":"The pathogenesis of Alzheimer's disease (AD) is closely related to several contributing factors, especially amyloid-beta (A beta) aggregation. Bioorthogonal reactions provide a general, facile, and robust route for the localization and derivatization of A beta-targeted agents. Herein, a pair of chiral alkyne-containing metallohelices (lambda A and & UDelta;A) were demonstrated to enantioselectively target and modulate A beta aggregation, which has been monitored in triple-transgenic AD model mice and proved to improve cognitive function. Compared with its enantiomer & UDelta;A, lambda A performed better in blocking A beta fibrillation, relieving A beta-triggered toxicity, and recovering memory deficits in vivo. Moreover, clickable lambda A could act as a functional module for subsequent visualization and versatile modification of amyloid via bioorthogonal reaction. As a proof-of-concept, thioflavin T, tacrine, and magnetic nanoparticles were conjugated with lambda A to realize A beta photo-oxygenation, acetylcholinesterase inhibition, and A beta clearance, respectively. This proof-of-principle work provided new insights into the biolabeling and bioconjugation of multifunctional metallosupramolecules through click reactions for AD therapy.","number":"3","urldate":"2022-12-22","journal":"CHEMICAL SCIENCE","author":[{"propositions":[],"lastnames":["Du"],"firstnames":["Zhi"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Chun"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Zhenqi"],"suffixes":[]},{"propositions":[],"lastnames":["Song"],"firstnames":["Hualong"],"suffixes":[]},{"propositions":[],"lastnames":["Scott"],"firstnames":["Peter"],"suffixes":[]},{"propositions":[],"lastnames":["Du"],"firstnames":["Xiubo"],"suffixes":[]},{"propositions":[],"lastnames":["Ren"],"firstnames":["Jinsong"],"suffixes":[]},{"propositions":[],"lastnames":["Qu"],"firstnames":["Xiaogang"],"suffixes":[]}],"month":"January","year":"2023","pages":"506–513","bibtex":"@article{du_vivo_2023,\n\ttitle = {In vivo visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices},\n\tvolume = {14},\n\tissn = {2041-6520},\n\tdoi = {10.1039/d2sc05897a},\n\tabstract = {The pathogenesis of Alzheimer's disease (AD) is closely related to several contributing factors, especially amyloid-beta (A beta) aggregation. Bioorthogonal reactions provide a general, facile, and robust route for the localization and derivatization of A beta-targeted agents. Herein, a pair of chiral alkyne-containing metallohelices (lambda A and \\& UDelta;A) were demonstrated to enantioselectively target and modulate A beta aggregation, which has been monitored in triple-transgenic AD model mice and proved to improve cognitive function. Compared with its enantiomer \\& UDelta;A, lambda A performed better in blocking A beta fibrillation, relieving A beta-triggered toxicity, and recovering memory deficits in vivo. Moreover, clickable lambda A could act as a functional module for subsequent visualization and versatile modification of amyloid via bioorthogonal reaction. As a proof-of-concept, thioflavin T, tacrine, and magnetic nanoparticles were conjugated with lambda A to realize A beta photo-oxygenation, acetylcholinesterase inhibition, and A beta clearance, respectively. This proof-of-principle work provided new insights into the biolabeling and bioconjugation of multifunctional metallosupramolecules through click reactions for AD therapy.},\n\tnumber = {3},\n\turldate = {2022-12-22},\n\tjournal = {CHEMICAL SCIENCE},\n\tauthor = {Du, Zhi and Liu, Chun and Liu, Zhenqi and Song, Hualong and Scott, Peter and Du, Xiubo and Ren, Jinsong and Qu, Xiaogang},\n\tmonth = jan,\n\tyear = {2023},\n\tpages = {506--513},\n}\n\n","author_short":["Du, Z.","Liu, C.","Liu, Z.","Song, H.","Scott, P.","Du, X.","Ren, J.","Qu, X."],"key":"du_vivo_2023","id":"du_vivo_2023","bibbaseid":"du-liu-liu-song-scott-du-ren-qu-invivovisualizationofenantioselectivetargetingofamyloidandimprovementofcognitivefunctionbyclickablechiralmetallohelices-2023","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://warwick.ac.uk/fac/cross_fac/wesic/research/wpg/research/WPGsep2024.bib","dataSources":["m4fxWT6XKrYfGbZFR","GBhqMC9hjyD5vqptk","6idaYK6okJY39mWgG"],"keywords":[],"search_terms":["vivo","visualization","enantioselective","targeting","amyloid","improvement","cognitive","function","clickable","chiral","metallohelices","du","liu","liu","song","scott","du","ren","qu"],"title":"In vivo visualization of enantioselective targeting of amyloid and improvement of cognitive function by clickable chiral metallohelices","year":2023}