@article{RN301,
   author = {Duarte-Salles, T. and Vizcaya, D. and Pistillo, A. and Casajust, P. and Sena, A. G. and Lai, L. Y. H. and Prats-Uribe, A. and Ahmed, W. U. and Alshammari, T. M. and Alghoul, H. and Alser, O. and Burn, E. and You, S. C. and Areia, C. and Blacketer, C. and DuVall, S. and Falconer, T. and Fernandez-Bertolin, S. and Fortin, S. and Golozar, A. and Gong, M. and Tan, E. H. and Huser, V. and Iveli, P. and Morales, D. R. and Nyberg, F. and Posada, J. D. and Recalde, M. and Roel, E. and Schilling, L. M. and Shah, N. H. and Shah, K. and Suchard, M. A. and Zhang, L. and Zhang, Y. and Williams, A. E. and Reich, C. G. and Hripcsak, G. and Rijnbeek, P. and Ryan, P. and Kostka, K. and Prieto-Alhambra, D.},
   title = {Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience},
   journal = {Pediatrics},
   volume = {148},
   number = {3},
   note = {1098-4275 Duarte-Salles, Talita Vizcaya, David Pistillo, Andrea Casajust, Paula Sena, Anthony G Lai, Lana Yin Hui Prats-Uribe, Albert Ahmed, Waheed-Ul-Rahman Alshammari, Thamir M Alghoul, Heba Alser, Osaid Burn, Edward You, Seng Chan Areia, Carlos Blacketer, Clair DuVall, Scott Falconer, Thomas Fernandez-Bertolin, Sergio Fortin, Stephen Golozar, Asieh Gong, Mengchun Tan, Eng Hooi Huser, Vojtech Iveli, Pablo Morales, Daniel R Nyberg, Fredrik Posada, Jose D Recalde, Martina Roel, Elena Schilling, Lisa M Shah, Nigam H Shah, Karishma Suchard, Marc A Zhang, Lin Zhang, Ying Williams, Andrew E Reich, Christian G Hripcsak, George Rijnbeek, Peter Ryan, Patrick Kostka, Kristin Prieto-Alhambra, Daniel Comparative Study Journal Article Research Support, Non-U.S. Gov't United States 2021/05/30 Pediatrics. 2021 Sep;148(3):e2020042929. doi: 10.1542/peds.2020-042929. Epub 2021 May 28.},
   abstract = {OBJECTIVES: To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018. METHODS: International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death. RESULTS: A total of 242 158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2 084 180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza. CONCLUSIONS: Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.},
   keywords = {Adolescent
Age Distribution
*COVID-19/complications/diagnosis/epidemiology
Child
Child, Preschool
Cohort Studies
Comorbidity
Databases, Factual
Diagnosis, Differential
Female
France/epidemiology
Germany/epidemiology
Hospitalization/statistics & numerical data
Humans
Infant
Infant, Newborn
Influenza, Human/complications/diagnosis/epidemiology
Male
Republic of Korea/epidemiology
Spain/epidemiology
Symptom Assessment
Time Factors
Treatment Outcome
United States/epidemiology
*COVID-19 Drug Treatment ,
ISSN = 0031-4005 ,
DOI = 10.1542/peds.2020-042929},
   year = {2021},
   type = {Journal Article}
}

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G.","Hripcsak, G.","Rijnbeek, P.","Ryan, P.","Kostka, K.","Prieto-Alhambra, D."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Duarte-Salles"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Vizcaya"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Pistillo"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Casajust"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Sena"],"firstnames":["A.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Lai"],"firstnames":["L.","Y.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Prats-Uribe"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Ahmed"],"firstnames":["W.","U."],"suffixes":[]},{"propositions":[],"lastnames":["Alshammari"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Alghoul"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Alser"],"firstnames":["O."],"suffixes":[]},{"propositions":[],"lastnames":["Burn"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["You"],"firstnames":["S.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Areia"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Blacketer"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["DuVall"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Falconer"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Fernandez-Bertolin"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Fortin"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Golozar"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Gong"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Tan"],"firstnames":["E.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Huser"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Iveli"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Morales"],"firstnames":["D.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Nyberg"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["Posada"],"firstnames":["J.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Recalde"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Roel"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Schilling"],"firstnames":["L.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Shah"],"firstnames":["N.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Shah"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Suchard"],"firstnames":["M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Williams"],"firstnames":["A.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Reich"],"firstnames":["C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Hripcsak"],"firstnames":["G."],"suffixes":[]},{"propositions":[],"lastnames":["Rijnbeek"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Ryan"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Kostka"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Prieto-Alhambra"],"firstnames":["D."],"suffixes":[]}],"title":"Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience","journal":"Pediatrics","volume":"148","number":"3","note":"1098-4275 Duarte-Salles, Talita Vizcaya, David Pistillo, Andrea Casajust, Paula Sena, Anthony G Lai, Lana Yin Hui Prats-Uribe, Albert Ahmed, Waheed-Ul-Rahman Alshammari, Thamir M Alghoul, Heba Alser, Osaid Burn, Edward You, Seng Chan Areia, Carlos Blacketer, Clair DuVall, Scott Falconer, Thomas Fernandez-Bertolin, Sergio Fortin, Stephen Golozar, Asieh Gong, Mengchun Tan, Eng Hooi Huser, Vojtech Iveli, Pablo Morales, Daniel R Nyberg, Fredrik Posada, Jose D Recalde, Martina Roel, Elena Schilling, Lisa M Shah, Nigam H Shah, Karishma Suchard, Marc A Zhang, Lin Zhang, Ying Williams, Andrew E Reich, Christian G Hripcsak, George Rijnbeek, Peter Ryan, Patrick Kostka, Kristin Prieto-Alhambra, Daniel Comparative Study Journal Article Research Support, Non-U.S. Gov't United States 2021/05/30 Pediatrics. 2021 Sep;148(3):e2020042929. doi: 10.1542/peds.2020-042929. Epub 2021 May 28.","abstract":"OBJECTIVES: To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018. METHODS: International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death. RESULTS: A total of 242 158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2 084 180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza. CONCLUSIONS: Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.","keywords":"Adolescent Age Distribution *COVID-19/complications/diagnosis/epidemiology Child Child, Preschool Cohort Studies Comorbidity Databases, Factual Diagnosis, Differential Female France/epidemiology Germany/epidemiology Hospitalization/statistics & numerical data Humans Infant Infant, Newborn Influenza, Human/complications/diagnosis/epidemiology Male Republic of Korea/epidemiology Spain/epidemiology Symptom Assessment Time Factors Treatment Outcome United States/epidemiology *COVID-19 Drug Treatment , ISSN = 0031-4005 , DOI = 10.1542/peds.2020-042929","year":"2021","bibtex":"@article{RN301,\r\n author = {Duarte-Salles, T. and Vizcaya, D. and Pistillo, A. and Casajust, P. and Sena, A. G. and Lai, L. Y. H. and Prats-Uribe, A. and Ahmed, W. U. and Alshammari, T. M. and Alghoul, H. and Alser, O. and Burn, E. and You, S. C. and Areia, C. and Blacketer, C. and DuVall, S. and Falconer, T. and Fernandez-Bertolin, S. and Fortin, S. and Golozar, A. and Gong, M. and Tan, E. H. and Huser, V. and Iveli, P. and Morales, D. R. and Nyberg, F. and Posada, J. D. and Recalde, M. and Roel, E. and Schilling, L. M. and Shah, N. H. and Shah, K. and Suchard, M. A. and Zhang, L. and Zhang, Y. and Williams, A. E. and Reich, C. G. and Hripcsak, G. and Rijnbeek, P. and Ryan, P. and Kostka, K. and Prieto-Alhambra, D.},\r\n title = {Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience},\r\n journal = {Pediatrics},\r\n volume = {148},\r\n number = {3},\r\n note = {1098-4275 Duarte-Salles, Talita Vizcaya, David Pistillo, Andrea Casajust, Paula Sena, Anthony G Lai, Lana Yin Hui Prats-Uribe, Albert Ahmed, Waheed-Ul-Rahman Alshammari, Thamir M Alghoul, Heba Alser, Osaid Burn, Edward You, Seng Chan Areia, Carlos Blacketer, Clair DuVall, Scott Falconer, Thomas Fernandez-Bertolin, Sergio Fortin, Stephen Golozar, Asieh Gong, Mengchun Tan, Eng Hooi Huser, Vojtech Iveli, Pablo Morales, Daniel R Nyberg, Fredrik Posada, Jose D Recalde, Martina Roel, Elena Schilling, Lisa M Shah, Nigam H Shah, Karishma Suchard, Marc A Zhang, Lin Zhang, Ying Williams, Andrew E Reich, Christian G Hripcsak, George Rijnbeek, Peter Ryan, Patrick Kostka, Kristin Prieto-Alhambra, Daniel Comparative Study Journal Article Research Support, Non-U.S. Gov't United States 2021/05/30 Pediatrics. 2021 Sep;148(3):e2020042929. doi: 10.1542/peds.2020-042929. Epub 2021 May 28.},\r\n abstract = {OBJECTIVES: To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018. METHODS: International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death. RESULTS: A total of 242 158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2 084 180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza. CONCLUSIONS: Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.},\r\n keywords = {Adolescent\r\nAge Distribution\r\n*COVID-19/complications/diagnosis/epidemiology\r\nChild\r\nChild, Preschool\r\nCohort Studies\r\nComorbidity\r\nDatabases, Factual\r\nDiagnosis, Differential\r\nFemale\r\nFrance/epidemiology\r\nGermany/epidemiology\r\nHospitalization/statistics & numerical data\r\nHumans\r\nInfant\r\nInfant, Newborn\r\nInfluenza, Human/complications/diagnosis/epidemiology\r\nMale\r\nRepublic of Korea/epidemiology\r\nSpain/epidemiology\r\nSymptom Assessment\r\nTime Factors\r\nTreatment Outcome\r\nUnited States/epidemiology\r\n*COVID-19 Drug Treatment ,\r\nISSN = 0031-4005 ,\r\nDOI = 10.1542/peds.2020-042929},\r\n year = {2021},\r\n type = {Journal Article}\r\n}\r\n\r\n","author_short":["Duarte-Salles, T.","Vizcaya, D.","Pistillo, A.","Casajust, P.","Sena, A. G.","Lai, L. Y. H.","Prats-Uribe, A.","Ahmed, W. U.","Alshammari, T. M.","Alghoul, H.","Alser, O.","Burn, E.","You, S. C.","Areia, C.","Blacketer, C.","DuVall, S.","Falconer, T.","Fernandez-Bertolin, S.","Fortin, S.","Golozar, A.","Gong, M.","Tan, E. H.","Huser, V.","Iveli, P.","Morales, D. R.","Nyberg, F.","Posada, J. D.","Recalde, M.","Roel, E.","Schilling, L. M.","Shah, N. H.","Shah, K.","Suchard, M. A.","Zhang, L.","Zhang, Y.","Williams, A. E.","Reich, C. G.","Hripcsak, G.","Rijnbeek, P.","Ryan, P.","Kostka, K.","Prieto-Alhambra, D."],"key":"RN301","id":"RN301","bibbaseid":"duartesalles-vizcaya-pistillo-casajust-sena-lai-pratsuribe-ahmed-etal-thirtydayoutcomesofchildrenandadolescentswithcovid19aninternationalexperience-2021","role":"author","urls":{},"keyword":["Adolescent Age Distribution *COVID-19/complications/diagnosis/epidemiology Child Child","Preschool Cohort Studies Comorbidity Databases","Factual Diagnosis","Differential Female France/epidemiology Germany/epidemiology Hospitalization/statistics & numerical data Humans Infant Infant","Newborn Influenza","Human/complications/diagnosis/epidemiology Male Republic of Korea/epidemiology Spain/epidemiology Symptom Assessment Time Factors Treatment Outcome United States/epidemiology *COVID-19 Drug Treatment","ISSN = 0031-4005","DOI = 10.1542/peds.2020-042929"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/network/files/qwipow2DJsAxqNp83","dataSources":["PJSqX8FMpCPRdw3CQ","qLDnCcKM9omXNrRY8","TB9sD3avjy7bNxfgS","vDmJPYmHEKAT3tMNL","PcZMFHooKwpboi2he","jZMXEeHTfokmisJDv"],"keywords":["adolescent age distribution *covid-19/complications/diagnosis/epidemiology child child","preschool cohort studies comorbidity databases","factual diagnosis","differential female france/epidemiology germany/epidemiology hospitalization/statistics & numerical data humans infant infant","newborn influenza","human/complications/diagnosis/epidemiology male republic of korea/epidemiology spain/epidemiology symptom assessment time factors treatment outcome united states/epidemiology *covid-19 drug treatment","issn = 0031-4005","doi = 10.1542/peds.2020-042929"],"search_terms":["thirty","day","outcomes","children","adolescents","covid","international","experience","duarte-salles","vizcaya","pistillo","casajust","sena","lai","prats-uribe","ahmed","alshammari","alghoul","alser","burn","you","areia","blacketer","duvall","falconer","fernandez-bertolin","fortin","golozar","gong","tan","huser","iveli","morales","nyberg","posada","recalde","roel","schilling","shah","shah","suchard","zhang","zhang","williams","reich","hripcsak","rijnbeek","ryan","kostka","prieto-alhambra"],"title":"Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience","year":2021}