@article{Dube2023,
abstract = {Herein, we describe 39 novel quinolone compounds bearing a hydrophilic amine chain and varied substituted benzyloxy units. These compounds demonstrate broad-spectrum activities against acid-fast bacterium, Gram-positive and -negative bacteria, fungi, and leishmania parasite. Compound 30 maintained antitubercular activity against moxifloxacin-, isoniazid-, and rifampicin-resistant Mycobacterium tuberculosis, while 37 exhibited low micromolar activities ({\textless}1 $\mu$g/mL) against World Health Organization (WHO) critical pathogens: Cryptococcus neoformans, Acinetobacter baumannii, and Pseudomonas aeruginosa. Compounds in this study are metabolically robust, demonstrating {\%} remnant of {\textgreater}98{\%} after 30 min in the presence of human, rat, and mouse liver microsomes. Several compounds thus reported here are promising leads for the treatment of diseases caused by infectious agents.},
author = {Dube, Phelelisiwe S and Angula, Klaudia T and Legoabe, Lesetja J and Jordaan, Audrey and Zarella, Jan M Boitz and Warner, Digby F and Doggett, J Stone and Beteck, Richard M},
doi = {10.1021/ACSOMEGA.3C01406},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Dube et al. - 2023 - Quinolone-3-amidoalkanol a new class of potent and broad-spectrum antimicrobial agent.pdf:pdf},
issn = {2470-1343},
journal = {ACS Omega},
keywords = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
month = {may},
pages = {10.1021/acsomega.3c01406},
pmid = {37214682},
publisher = {American Chemical Society},
title = {{Quinolone-3-amidoalkanol: a new class of potent and broad-spectrum antimicrobial agent}},
url = {https://pubs.acs.org/doi/full/10.1021/acsomega.3c01406},
year = {2023}
}

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