@article{ ducottet_effects_2003,
  title = {Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice},
  volume = {27},
  issn = {0278-5846},
  doi = {10.1016/S0278-5846(03)00051-4},
  abstract = {Several recent studies on corticotropin-releasing factor ({CRF}) have suggested that this neuropeptide may play a role in depression. Consequently, {CRF} receptor antagonists have been proposed as potential new agents for the treatment of this condition. This study investigated the effects of a 4-week treatment with the well-known {CRF}(1) receptor antagonist, antalarmin, and the prototypical selective serotonin reuptake inhibitor ({SSRI}), fluoxetine, in the chronic mild stress ({CMS}) model in {BALB}/c mice. Animals were exposed to 9 weeks of {CMS} which rapidly (within 2 weeks) produced decrease of physical state ({PS}), body weight gain and blunted emotional response in the light/dark test. Chronic treatment with antalarmin (10 mg/kg ip) and fluoxetine (10 mg/kg ip) led to an improvement of {CMS}-induced modifications. These results suggest that {CRF}(1) receptor antagonists may represent potential antidepressants.},
  language = {eng},
  number = {4},
  journal = {Progress in Neuro-Psychopharmacology \& Biological Psychiatry},
  author = {Ducottet, Cecile and Griebel, Guy and Belzung, Catherine},
  month = {June},
  year = {2003},
  pmid = {12787849},
  keywords = {Animals, Depression, Disease Models, Animal, Drug Therapy, Combination, Fluoxetine, Male, Mice, Mice, Inbred {BALB} C, Pyrimidines, Pyrroles, Receptors, Corticotropin-Releasing Hormone, Serotonin Uptake Inhibitors, Stress, Psychological},
  pages = {625--631}
}

{"_id":"5cYvtzue3efacNA8i","authorIDs":[],"author_short":["Ducottet, C.","Griebel, G.","Belzung, C."],"bibbaseid":"ducottet-griebel-belzung-effectsoftheselectivenonpeptidecorticotropinreleasingfactorreceptor1antagonistantalarmininthechronicmildstressmodelofdepressioninmice-2003","bibdata":{"abstract":"Several recent studies on corticotropin-releasing factor (CRF) have suggested that this neuropeptide may play a role in depression. Consequently, CRF receptor antagonists have been proposed as potential new agents for the treatment of this condition. This study investigated the effects of a 4-week treatment with the well-known CRF(1) receptor antagonist, antalarmin, and the prototypical selective serotonin reuptake inhibitor (SSRI), fluoxetine, in the chronic mild stress (CMS) model in BALB/c mice. Animals were exposed to 9 weeks of CMS which rapidly (within 2 weeks) produced decrease of physical state (PS), body weight gain and blunted emotional response in the light/dark test. Chronic treatment with antalarmin (10 mg/kg ip) and fluoxetine (10 mg/kg ip) led to an improvement of CMS-induced modifications. These results suggest that CRF(1) receptor antagonists may represent potential antidepressants.","author":["Ducottet, Cecile","Griebel, Guy","Belzung, Catherine"],"author_short":["Ducottet, C.","Griebel, G.","Belzung, C."],"bibtex":"@article{ ducottet_effects_2003,\n title = {Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice},\n volume = {27},\n issn = {0278-5846},\n doi = {10.1016/S0278-5846(03)00051-4},\n abstract = {Several recent studies on corticotropin-releasing factor ({CRF}) have suggested that this neuropeptide may play a role in depression. Consequently, {CRF} receptor antagonists have been proposed as potential new agents for the treatment of this condition. This study investigated the effects of a 4-week treatment with the well-known {CRF}(1) receptor antagonist, antalarmin, and the prototypical selective serotonin reuptake inhibitor ({SSRI}), fluoxetine, in the chronic mild stress ({CMS}) model in {BALB}/c mice. Animals were exposed to 9 weeks of {CMS} which rapidly (within 2 weeks) produced decrease of physical state ({PS}), body weight gain and blunted emotional response in the light/dark test. Chronic treatment with antalarmin (10 mg/kg ip) and fluoxetine (10 mg/kg ip) led to an improvement of {CMS}-induced modifications. These results suggest that {CRF}(1) receptor antagonists may represent potential antidepressants.},\n language = {eng},\n number = {4},\n journal = {Progress in Neuro-Psychopharmacology \\& Biological Psychiatry},\n author = {Ducottet, Cecile and Griebel, Guy and Belzung, Catherine},\n month = {June},\n year = {2003},\n pmid = {12787849},\n keywords = {Animals, Depression, Disease Models, Animal, Drug Therapy, Combination, Fluoxetine, Male, Mice, Mice, Inbred {BALB} C, Pyrimidines, Pyrroles, Receptors, Corticotropin-Releasing Hormone, Serotonin Uptake Inhibitors, Stress, Psychological},\n pages = {625--631}\n}","bibtype":"article","doi":"10.1016/S0278-5846(03)00051-4","id":"ducottet_effects_2003","issn":"0278-5846","journal":"Progress in Neuro-Psychopharmacology \\& Biological Psychiatry","key":"ducottet_effects_2003","keywords":"Animals, Depression, Disease Models, Animal, Drug Therapy, Combination, Fluoxetine, Male, Mice, Mice, Inbred BALB C, Pyrimidines, Pyrroles, Receptors, Corticotropin-Releasing Hormone, Serotonin Uptake Inhibitors, Stress, Psychological","language":"eng","month":"June","number":"4","pages":"625--631","pmid":"12787849","title":"Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice","type":"article","volume":"27","year":"2003","bibbaseid":"ducottet-griebel-belzung-effectsoftheselectivenonpeptidecorticotropinreleasingfactorreceptor1antagonistantalarmininthechronicmildstressmodelofdepressioninmice-2003","role":"author","urls":{},"keyword":["Animals","Depression","Disease Models","Animal","Drug Therapy","Combination","Fluoxetine","Male","Mice","Mice","Inbred BALB C","Pyrimidines","Pyrroles","Receptors","Corticotropin-Releasing Hormone","Serotonin Uptake Inhibitors","Stress","Psychological"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/users/1159944/collections/PSAWXGQV/items?key=8pKJLEr2Uh7GZN5GrRPdT9lZ&format=bibtex&limit=100","creationDate":"2015-02-11T08:36:05.806Z","downloads":0,"keywords":["animals","depression","disease models","animal","drug therapy","combination","fluoxetine","male","mice","mice","inbred balb c","pyrimidines","pyrroles","receptors","corticotropin-releasing hormone","serotonin uptake inhibitors","stress","psychological"],"search_terms":["effects","selective","nonpeptide","corticotropin","releasing","factor","receptor","antagonist","antalarmin","chronic","mild","stress","model","depression","mice","ducottet","griebel","belzung"],"title":"Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice","year":2003,"dataSources":["FRxCKR7bxZrk5oFSo"]}