@article{RN331,
   author = {Duffner, L. A. and DeJong, N. and Jansen, J. F. A. and Backes, W. and de Vugt, M. and Deckers, K. and Kohler, S.},
   title = {Associations between social health factors, cognitive activity and neurostructural markers for brain health - a systematic literature review and meta-analysis},
   journal = {Ageing Res Rev},
   pages = {101986},
   note = {Duffner, Lukas A
DeJong, Nathan
Jansen, Jacobus F A
Backes, Walter
de Vugt, Marjolein
Deckers, Kay
Kohler, Sebastian
eng
Review
England
Ageing Res Rev. 2023 Jun 23:101986. doi: 10.1016/j.arr.2023.101986.},
   abstract = {Social health factors (e.g., social activities or social support) and cognitive activity engagement have been associated with dementia risk, but their neural substrates have not been well established. This systematic review and meta-analysis summarizes the available evidence regarding the association between these factors and cerebral macro- and microstructure. A comprehensive literature search was conducted in various databases, following predefined criteria. Heterogeneity, risk of publication bias and overall certainty of evidence were assessed using standardized scales and, whenever appropriate, random effects meta-analysis was conducted. Of 6,715 identified articles, 43 were included. Overall, consistency of findings was low and methodological heterogeneity high for all outcomes. However, in some studies cognitive and social activities were positively associated with total brain, global and cortical grey matter and hippocampal volume as well as white matter microstructural integrity. Furthermore, structural social network characteristics (e.g., social network size) were associated with regional grey matter volumes, while functional social network characteristics (e.g., social support) were additionally associated with total brain volume. Meta-analyses revealed small but significant partial correlations between cognitive and social activities and hippocampal (three studies; n=892; r(z)=.07) and white matter hyperintensity volume (three studies; n=2934; r(z)=-.04). More prospective studies are needed to assess temporal associations.},
   keywords = {Mri
brain-health
dementia
prevention
social-health
declared Jacobus Jansen: none declared Walter Backes: none declared Marjolein de
Vugt: none declared Kay Deckers: none declared Sebastian Kohler: none declared},
   ISSN = {1872-9649 (Electronic)
1568-1637 (Linking)},
   DOI = {10.1016/j.arr.2023.101986},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/37356551},
   year = {2023},
   type = {Journal Article}
}

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A.","Backes, W.","de Vugt, M.","Deckers, K.","Kohler, S."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Duffner"],"firstnames":["L.","A."],"suffixes":[]},{"propositions":[],"lastnames":["DeJong"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W."],"suffixes":[]},{"propositions":["de"],"lastnames":["Vugt"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Deckers"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Kohler"],"firstnames":["S."],"suffixes":[]}],"title":"Associations between social health factors, cognitive activity and neurostructural markers for brain health - a systematic literature review and meta-analysis","journal":"Ageing Res Rev","pages":"101986","note":"Duffner, Lukas A DeJong, Nathan Jansen, Jacobus F A Backes, Walter de Vugt, Marjolein Deckers, Kay Kohler, Sebastian eng Review England Ageing Res Rev. 2023 Jun 23:101986. doi: 10.1016/j.arr.2023.101986.","abstract":"Social health factors (e.g., social activities or social support) and cognitive activity engagement have been associated with dementia risk, but their neural substrates have not been well established. This systematic review and meta-analysis summarizes the available evidence regarding the association between these factors and cerebral macro- and microstructure. A comprehensive literature search was conducted in various databases, following predefined criteria. Heterogeneity, risk of publication bias and overall certainty of evidence were assessed using standardized scales and, whenever appropriate, random effects meta-analysis was conducted. Of 6,715 identified articles, 43 were included. Overall, consistency of findings was low and methodological heterogeneity high for all outcomes. However, in some studies cognitive and social activities were positively associated with total brain, global and cortical grey matter and hippocampal volume as well as white matter microstructural integrity. Furthermore, structural social network characteristics (e.g., social network size) were associated with regional grey matter volumes, while functional social network characteristics (e.g., social support) were additionally associated with total brain volume. Meta-analyses revealed small but significant partial correlations between cognitive and social activities and hippocampal (three studies; n=892; r(z)=.07) and white matter hyperintensity volume (three studies; n=2934; r(z)=-.04). More prospective studies are needed to assess temporal associations.","keywords":"Mri brain-health dementia prevention social-health declared Jacobus Jansen: none declared Walter Backes: none declared Marjolein de Vugt: none declared Kay Deckers: none declared Sebastian Kohler: none declared","issn":"1872-9649 (Electronic) 1568-1637 (Linking)","doi":"10.1016/j.arr.2023.101986","url":"https://www.ncbi.nlm.nih.gov/pubmed/37356551","year":"2023","bibtex":"@article{RN331,\n author = {Duffner, L. A. and DeJong, N. and Jansen, J. F. A. and Backes, W. and de Vugt, M. and Deckers, K. and Kohler, S.},\n title = {Associations between social health factors, cognitive activity and neurostructural markers for brain health - a systematic literature review and meta-analysis},\n journal = {Ageing Res Rev},\n pages = {101986},\n note = {Duffner, Lukas A\nDeJong, Nathan\nJansen, Jacobus F A\nBackes, Walter\nde Vugt, Marjolein\nDeckers, Kay\nKohler, Sebastian\neng\nReview\nEngland\nAgeing Res Rev. 2023 Jun 23:101986. doi: 10.1016/j.arr.2023.101986.},\n abstract = {Social health factors (e.g., social activities or social support) and cognitive activity engagement have been associated with dementia risk, but their neural substrates have not been well established. This systematic review and meta-analysis summarizes the available evidence regarding the association between these factors and cerebral macro- and microstructure. A comprehensive literature search was conducted in various databases, following predefined criteria. Heterogeneity, risk of publication bias and overall certainty of evidence were assessed using standardized scales and, whenever appropriate, random effects meta-analysis was conducted. Of 6,715 identified articles, 43 were included. Overall, consistency of findings was low and methodological heterogeneity high for all outcomes. However, in some studies cognitive and social activities were positively associated with total brain, global and cortical grey matter and hippocampal volume as well as white matter microstructural integrity. Furthermore, structural social network characteristics (e.g., social network size) were associated with regional grey matter volumes, while functional social network characteristics (e.g., social support) were additionally associated with total brain volume. Meta-analyses revealed small but significant partial correlations between cognitive and social activities and hippocampal (three studies; n=892; r(z)=.07) and white matter hyperintensity volume (three studies; n=2934; r(z)=-.04). More prospective studies are needed to assess temporal associations.},\n keywords = {Mri\nbrain-health\ndementia\nprevention\nsocial-health\ndeclared Jacobus Jansen: none declared Walter Backes: none declared Marjolein de\nVugt: none declared Kay Deckers: none declared Sebastian Kohler: none declared},\n ISSN = {1872-9649 (Electronic)\n1568-1637 (Linking)},\n DOI = {10.1016/j.arr.2023.101986},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/37356551},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["Duffner, L. A.","DeJong, N.","Jansen, J. F. 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