@article{ dufour-rainfray_behavior_2010,
  title = {Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism},
  volume = {470},
  issn = {1872-7972},
  shorttitle = {Behavior and serotonergic disorders in rats exposed prenatally to valproate},
  doi = {10.1016/j.neulet.2009.12.054},
  abstract = {In order to explore whether some aspects of the autistic phenotype could be related to impairment of the serotonergic system, we chose an animal model which mimics a potential cause of autism, i.e. rats exposed to valproate ({VPA}) on the 9th embryonic day (E9). Previous studies have suggested that {VPA} exposure in rats at E9 caused a dramatic shift in the distribution of serotonergic neurons on postnatal day 50 ({PND}50). Behavioral studies have also been performed but on rats that were exposed to {VPA} later (E12.5). Our aim was to test whether {VPA} exposure at E9 induces comparable behavioral impairments than at E12.5 and causes serotonergic impairments which could be related to behavioral modifications. The results showed significant behavioral impairments such as a lower tendency to initiate social interactions and hyperlocomotor activity in juvenile male rats. The serotonin levels of these animals at {PND}50 were decreased (-46%) in the hippocampus, a structure involved in social behavior. This study suggests that {VPA} could have a direct or indirect action on the serotonergic system as early as the progenitor cell stage. Early embryonic exposure to {VPA} in rats provides a good model for several specific aspects of autism and should help to continue to explore pathophysiological hypotheses.},
  language = {eng},
  number = {1},
  journal = {Neuroscience Letters},
  author = {Dufour-Rainfray, Diane and Vourc'h, Patrick and Le Guisquet, Anne-Marie and Garreau, Lucette and Ternant, David and Bodard, Sylvie and Jaumain, Emilie and Gulhan, Zuhal and Belzung, Catherine and Andres, Christian R. and Chalon, Sylvie and Guilloteau, Denis},
  month = {February},
  year = {2010},
  pmid = {20036713},
  keywords = {Animals, Autistic Disorder, Behavior, Animal, Brain, Disease Models, Animal, Female, {GABA} Agents, Hippocampus, Hydroxyindoleacetic Acid, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, {RNA}-Binding Proteins, Rats, Rats, Wistar, Serotonin, Social Behavior, Time Factors, Valproic Acid},
  pages = {55--59}
}

{"_id":"3dmhTASs34xHgYzPS","authorIDs":[],"author_short":["Dufour-Rainfray, D.","Vourc'h, P.","Guisquet, A.<nbsp>L.","Garreau, L.","Ternant, D.","Bodard, S.","Jaumain, E.","Gulhan, Z.","Belzung, C.","Andres, C.<nbsp>R.","Chalon, S.","Guilloteau, D."],"bibbaseid":"dufourrainfray-vourch-guisquet-garreau-ternant-bodard-jaumain-gulhan-belzung-andres-chalon-guilloteau-behaviorandserotonergicdisordersinratsexposedprenatallytovalproateamodelforautism-2010","bibdata":{"abstract":"In order to explore whether some aspects of the autistic phenotype could be related to impairment of the serotonergic system, we chose an animal model which mimics a potential cause of autism, i.e. rats exposed to valproate (VPA) on the 9th embryonic day (E9). Previous studies have suggested that VPA exposure in rats at E9 caused a dramatic shift in the distribution of serotonergic neurons on postnatal day 50 (PND50). Behavioral studies have also been performed but on rats that were exposed to VPA later (E12.5). Our aim was to test whether VPA exposure at E9 induces comparable behavioral impairments than at E12.5 and causes serotonergic impairments which could be related to behavioral modifications. The results showed significant behavioral impairments such as a lower tendency to initiate social interactions and hyperlocomotor activity in juvenile male rats. The serotonin levels of these animals at PND50 were decreased (-46%) in the hippocampus, a structure involved in social behavior. This study suggests that VPA could have a direct or indirect action on the serotonergic system as early as the progenitor cell stage. Early embryonic exposure to VPA in rats provides a good model for several specific aspects of autism and should help to continue to explore pathophysiological hypotheses.","author":["Dufour-Rainfray, Diane","Vourc'h, Patrick","Guisquet, Anne-Marie Le","Garreau, Lucette","Ternant, David","Bodard, Sylvie","Jaumain, Emilie","Gulhan, Zuhal","Belzung, Catherine","Andres, Christian R.","Chalon, Sylvie","Guilloteau, Denis"],"author_short":["Dufour-Rainfray, D.","Vourc'h, P.","Guisquet, A.<nbsp>L.","Garreau, L.","Ternant, D.","Bodard, S.","Jaumain, E.","Gulhan, Z.","Belzung, C.","Andres, C.<nbsp>R.","Chalon, S.","Guilloteau, D."],"bibtex":"@article{ dufour-rainfray_behavior_2010,\n title = {Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism},\n volume = {470},\n issn = {1872-7972},\n shorttitle = {Behavior and serotonergic disorders in rats exposed prenatally to valproate},\n doi = {10.1016/j.neulet.2009.12.054},\n abstract = {In order to explore whether some aspects of the autistic phenotype could be related to impairment of the serotonergic system, we chose an animal model which mimics a potential cause of autism, i.e. rats exposed to valproate ({VPA}) on the 9th embryonic day (E9). Previous studies have suggested that {VPA} exposure in rats at E9 caused a dramatic shift in the distribution of serotonergic neurons on postnatal day 50 ({PND}50). Behavioral studies have also been performed but on rats that were exposed to {VPA} later (E12.5). Our aim was to test whether {VPA} exposure at E9 induces comparable behavioral impairments than at E12.5 and causes serotonergic impairments which could be related to behavioral modifications. The results showed significant behavioral impairments such as a lower tendency to initiate social interactions and hyperlocomotor activity in juvenile male rats. The serotonin levels of these animals at {PND}50 were decreased (-46%) in the hippocampus, a structure involved in social behavior. This study suggests that {VPA} could have a direct or indirect action on the serotonergic system as early as the progenitor cell stage. Early embryonic exposure to {VPA} in rats provides a good model for several specific aspects of autism and should help to continue to explore pathophysiological hypotheses.},\n language = {eng},\n number = {1},\n journal = {Neuroscience Letters},\n author = {Dufour-Rainfray, Diane and Vourc'h, Patrick and Le Guisquet, Anne-Marie and Garreau, Lucette and Ternant, David and Bodard, Sylvie and Jaumain, Emilie and Gulhan, Zuhal and Belzung, Catherine and Andres, Christian R. and Chalon, Sylvie and Guilloteau, Denis},\n month = {February},\n year = {2010},\n pmid = {20036713},\n keywords = {Animals, Autistic Disorder, Behavior, Animal, Brain, Disease Models, Animal, Female, {GABA} Agents, Hippocampus, Hydroxyindoleacetic Acid, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, {RNA}-Binding Proteins, Rats, Rats, Wistar, Serotonin, Social Behavior, Time Factors, Valproic Acid},\n pages = {55--59}\n}","bibtype":"article","doi":"10.1016/j.neulet.2009.12.054","id":"dufour-rainfray_behavior_2010","issn":"1872-7972","journal":"Neuroscience Letters","key":"dufour-rainfray_behavior_2010","keywords":"Animals, Autistic Disorder, Behavior, Animal, Brain, Disease Models, Animal, Female, GABA Agents, Hippocampus, Hydroxyindoleacetic Acid, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, RNA-Binding Proteins, Rats, Rats, Wistar, Serotonin, Social Behavior, Time Factors, Valproic Acid","language":"eng","month":"February","number":"1","pages":"55--59","pmid":"20036713","shorttitle":"Behavior and serotonergic disorders in rats exposed prenatally to valproate","title":"Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism","type":"article","volume":"470","year":"2010","bibbaseid":"dufourrainfray-vourch-guisquet-garreau-ternant-bodard-jaumain-gulhan-belzung-andres-chalon-guilloteau-behaviorandserotonergicdisordersinratsexposedprenatallytovalproateamodelforautism-2010","role":"author","urls":{},"keyword":["Animals","Autistic Disorder","Behavior","Animal","Brain","Disease Models","Animal","Female","GABA Agents","Hippocampus","Hydroxyindoleacetic Acid","Male","Motor Activity","Pregnancy","Prenatal Exposure Delayed Effects","RNA-Binding Proteins","Rats","Rats","Wistar","Serotonin","Social Behavior","Time Factors","Valproic Acid"],"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/brizard","creationDate":"2015-02-11T08:49:19.908Z","downloads":0,"keywords":["animals","autistic disorder","behavior","animal","brain","disease models","animal","female","gaba agents","hippocampus","hydroxyindoleacetic acid","male","motor activity","pregnancy","prenatal exposure delayed effects","rna-binding proteins","rats","rats","wistar","serotonin","social behavior","time factors","valproic acid"],"search_terms":["behavior","serotonergic","disorders","rats","exposed","prenatally","valproate","model","autism","dufour-rainfray","vourc'h","guisquet","garreau","ternant","bodard","jaumain","gulhan","belzung","andres","chalon","guilloteau"],"title":"Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism","year":2010,"dataSources":["H9yznXMN7R8ae2jTA"]}