Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study. Dumitrescu, L. A. C., Cara L. AND Taylor, K. A. S., Fredrick R. AND Hindorff, L. A. A. A., José L. AND Anderson, G. A. B., Lyle G. AND Brown-Gentry, K. A. B., Petra AND Carlson, C. S. A. C., Barbara AND Cole, S. A. A. D., Richard B. AND Duggan, D. A. E., Charles B. AND Fornage, M. A. F., Nora AND Haessler, J. A. H., Barbara V. AND Johnson, K. C. A. L., Sandra AND Kolonel, L. N. A. L., Elisa T. AND MacCluer, J. W. A. M., Teri A. AND Pendergrass, S. A. A. Q., Miguel AND Shohet, R. V. A. W., Lynne R. AND Haiman, C. A. A. L. M., Loïc AND Buyske, S. A. K., & Charles AND North, K. E. A. C. PLoS Genet, 7(6):e1002138, Public Library of Science, 06, 2011. ![Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Author Summary Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels are well known independent risk factors for cardiovascular disease. Lipid-associated genetic variants are being discovered in genome-wide association studies (GWAS) in samples of European descent, but an insufficient amount of data exist in other populations. Therefore, there is a strong need to characterize the effect of these GWAS identified variants in more diverse cohorts. In this study, we selected over forty genetic loci previously associated with lipid levels and tested for replication in a large European American cohort. We also investigated if the effect of these variants generalizes to non-European descent populations, including African Americans, American Indians, and Mexican Americans/Hispanics. A majority of these GWAS identified associations replicated in our European American cohort. However, the ability of associations to generalize across other racial/ethnic populations varied greatly, indicating that some of these GWAS identified variants may not be functional and are more likely to be in linkage disequilibrium with the functional variant(s).
@article{dumitrescu2012,
author = {Dumitrescu, Logan AND Carty, Cara L. AND Taylor, Kira AND Schumacher, Fredrick R. AND Hindorff, Lucia A. AND Ambite, José L. AND Anderson, Garnet AND Best, Lyle G. AND Brown-Gentry, Kristin AND Buzkova, Petra AND Carlson, Christopher S. AND Cochran, Barbara AND Cole, Shelley A. AND Devereux, Richard B. AND Duggan, Dave AND Eaton, Charles B. AND Fornage, Myriam AND Franceschini, Nora AND Haessler, Jeff AND Howard, Barbara V. AND Johnson, Karen C. AND Laston, Sandra AND Kolonel, Laurence N. AND Lee, Elisa T. AND MacCluer, Jean W. AND Manolio, Teri A. AND Pendergrass, Sarah A. AND Quibrera, Miguel AND Shohet, Ralph V. AND Wilkens, Lynne R. AND Haiman, Christopher A. AND Le Marchand, Loïc AND Buyske, Steven AND Kooperberg, Charles AND North, Kari E. AND Crawford, Dana C.},
journal = {PLoS Genet},
publisher = {Public Library of Science},
title = {Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study},
year = {2011},
month = {06},
volume = {7},
url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1002138},
pages = {e1002138},
abstract = {
<title>Author Summary</title>
<p>Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels are well known independent risk factors for cardiovascular disease. Lipid-associated genetic variants are being discovered in genome-wide association studies (GWAS) in samples of European descent, but an insufficient amount of data exist in other populations. Therefore, there is a strong need to characterize the effect of these GWAS identified variants in more diverse cohorts. In this study, we selected over forty genetic loci previously associated with lipid levels and tested for replication in a large European American cohort. We also investigated if the effect of these variants generalizes to non-European descent populations, including African Americans, American Indians, and Mexican Americans/Hispanics. A majority of these GWAS identified associations replicated in our European American cohort. However, the ability of associations to generalize across other racial/ethnic populations varied greatly, indicating that some of these GWAS identified variants may not be functional and are more likely to be in linkage disequilibrium with the functional variant(s).</p>
},
number = {6},
doi = {10.1371/journal.pgen.1002138}
}
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Q.","Miguel AND Shohet, R. V. A. W.","Lynne R. AND Haiman, C. A. A. L. M.","Loïc AND Buyske, S. A. K.","Charles AND North, K. E. A. C."],"year":2011,"bibtype":"article","biburl":"https://bibbase.org/f/ta8ksHbawf9Szsb3v/ambite-2023.bib","bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Dumitrescu"],"firstnames":["Logan","AND","Carty"],"suffixes":[]},{"propositions":[],"lastnames":["Cara","L.","AND","Taylor"],"firstnames":["Kira","AND","Schumacher"],"suffixes":[]},{"propositions":[],"lastnames":["Fredrick","R.","AND","Hindorff"],"firstnames":["Lucia","A.","AND","Ambite"],"suffixes":[]},{"propositions":[],"lastnames":["José","L.","AND","Anderson"],"firstnames":["Garnet","AND","Best"],"suffixes":[]},{"propositions":[],"lastnames":["Lyle","G.","AND","Brown-Gentry"],"firstnames":["Kristin","AND","Buzkova"],"suffixes":[]},{"propositions":[],"lastnames":["Petra","AND","Carlson"],"firstnames":["Christopher","S.","AND","Cochran"],"suffixes":[]},{"propositions":[],"lastnames":["Barbara","AND","Cole"],"firstnames":["Shelley","A.","AND","Devereux"],"suffixes":[]},{"propositions":[],"lastnames":["Richard","B.","AND","Duggan"],"firstnames":["Dave","AND","Eaton"],"suffixes":[]},{"propositions":[],"lastnames":["Charles","B.","AND","Fornage"],"firstnames":["Myriam","AND","Franceschini"],"suffixes":[]},{"propositions":[],"lastnames":["Nora","AND","Haessler"],"firstnames":["Jeff","AND","Howard"],"suffixes":[]},{"propositions":[],"lastnames":["Barbara","V.","AND","Johnson"],"firstnames":["Karen","C.","AND","Laston"],"suffixes":[]},{"propositions":[],"lastnames":["Sandra","AND","Kolonel"],"firstnames":["Laurence","N.","AND","Lee"],"suffixes":[]},{"propositions":[],"lastnames":["Elisa","T.","AND","MacCluer"],"firstnames":["Jean","W.","AND","Manolio"],"suffixes":[]},{"propositions":[],"lastnames":["Teri","A.","AND","Pendergrass"],"firstnames":["Sarah","A.","AND","Quibrera"],"suffixes":[]},{"propositions":[],"lastnames":["Miguel","AND","Shohet"],"firstnames":["Ralph","V.","AND","Wilkens"],"suffixes":[]},{"propositions":[],"lastnames":["Lynne","R.","AND","Haiman"],"firstnames":["Christopher","A.","AND","Le","Marchand"],"suffixes":[]},{"propositions":[],"lastnames":["Loïc","AND","Buyske"],"firstnames":["Steven","AND","Kooperberg"],"suffixes":[]},{"propositions":[],"lastnames":["Charles","AND","North"],"firstnames":["Kari","E.","AND","Crawford"],"suffixes":[]}],"journal":"PLoS Genet","publisher":"Public Library of Science","title":"Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study","year":"2011","month":"06","volume":"7","url":"http://dx.doi.org/10.1371%2Fjournal.pgen.1002138","pages":"e1002138","abstract":"<title>Author Summary</title> <p>Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels are well known independent risk factors for cardiovascular disease. 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