Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Dumitrescu, L., Goodloe, R., Brown-Gentry, K., Mayo, P., Allen, M., Jin, H., Gillani, N. B., Schnetz-Boutaud, N., Dilks, H. H., & Crawford, D. C. Human genetics, 131:1699–1708, November, 2012.
Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. [link]Paper  doi  abstract   bibtex   
Both environmental and genetic factors impact lipid traits. Environmental modifiers of known genotype-phenotype associations may account for some of the "missing heritability" of these traits. To identify such modifiers, we genotyped 23 lipid-associated variants identified previously through genome-wide association studies (GWAS) in 2,435 non-Hispanic white, 1,407 non-Hispanic black, and 1,734 Mexican-American samples collected for the National Health and Nutrition Examination Surveys (NHANES). Along with lipid levels, NHANES collected environmental variables, including fat-soluble macronutrient serum levels of vitamin A and E levels. As part of the Population Architecture using Genomics and Epidemiology (PAGE) study, we modeled gene-environment interactions between vitamin A or vitamin E and 23 variants previously associated with high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels. We identified three SNP × vitamin A and six SNP × vitamin E interactions at a significance threshold of p < 2.2 × 10(-3). The most significant interaction was APOB rs693 × vitamin E (p = 8.9 × 10(-7)) for LDL-C levels among Mexican-Americans. The nine significant interaction models individually explained 0.35-1.61% of the variation in any one of the lipid traits. Our results suggest that vitamins A and E may modify known genotype-phenotype associations; however, these interactions account for only a fraction of the overall variability observed for HDL-C, LDL-C, and TG levels in the general population.
@article{DumitrescuGoodloeBrownGentryEtAl2012,
	abstract = {Both environmental and genetic factors impact lipid traits. Environmental modifiers of known genotype-phenotype associations may account for some of the "missing heritability" of these traits. To identify such modifiers, we genotyped 23 lipid-associated variants identified previously through genome-wide association studies ({GWAS}) in 2,435 non-Hispanic white, 1,407 non-Hispanic black, and 1,734 Mexican-American samples collected for the National Health and Nutrition Examination Surveys (NHANES). Along with lipid levels, NHANES collected environmental variables, including fat-soluble macronutrient serum levels of vitamin A and E levels. As part of the {Population Architecture using Genomics and Epidemiology} (PAGE) study, we modeled gene-environment interactions between vitamin A or vitamin E and 23 variants previously associated with high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels. We identified three {SNP} × vitamin A and six {SNP} × vitamin E interactions at a significance threshold of p < 2.2 × 10(-3). The most significant interaction was APOB rs693 × vitamin E (p = 8.9 × 10(-7)) for LDL-C levels among Mexican-Americans. The nine significant interaction models individually explained 0.35-1.61% of the variation in any one of the lipid traits. Our results suggest that vitamins A and E may modify known genotype-phenotype associations; however, these interactions account for only a fraction of the overall variability observed for HDL-C, LDL-C, and TG levels in the general population.},
	author = {Dumitrescu, Logan and Goodloe, Robert and Brown-Gentry, Kristin and Mayo, Ping and Allen, Melissa and Jin, Hailing and Gillani, Niloufar B. and Schnetz-Boutaud, Nathalie and Dilks, Holli H. and Crawford, Dana C.},
	chemicals = {Cholesterol, HDL, Cholesterol, LDL, Genetic Markers, Triglycerides, Vitamin A, Vitamin E},
	citation-subset = {IM},
	completed = {2013-01-08},
	country = {Germany},
	doi = {10.1007/s00439-012-1186-y},
	issn = {1432-1203},
	issn-linking = {0340-6717},
	issue = {11},
	journal = {Human genetics},
	keywords = {Adult; African Americans, genetics; Cholesterol, HDL, genetics; Cholesterol, LDL, genetics; Cohort Studies; European Continental Ancestry Group, genetics; Female; Fluorescent Antibody Technique; Gene-Environment Interaction; Genetic Association Studies; Genetic Markers; Genome-Wide Association Study; Humans; Mexican Americans, genetics; Molecular Epidemiology; Nutrition Surveys; Polymorphism, Single Nucleotide, genetics; Quantitative Trait Loci; Risk Factors; Triglycerides, genetics; Vitamin A, blood; Vitamin E, blood},
	mid = {NIHMS391691},
	month = nov,
	nlm-id = {7613873},
	owner = {NLM},
	pages = {1699--1708},
	pmc = {PMC3472117},
	pmid = {22688886},
	url = {https://urldefense.com/v2/url?u=https-3A__pubmed.ncbi.nlm.nih.gov_22688886_&d=DwIGaQ&c=qzHnJIRvjI6L-clJH8JwLQvf_Iq43fzikf6aoxZgMb8&r=OLzLRGPbIXJFFGZfvNEKwg&m=SekvZxn15HCHj0kI8aHOjpHB1QfCfJ_plk06JUgkfzw&s=lhXjK2FC8FXFbL82dxD54MSYtNqGw3AtsT5aa5UsBWM&e= },
	pubmodel = {Print-Electronic},
	pubstate = {ppublish},
	revised = {2018-11-13},
	title = {Serum vitamins {A} and {E} as modifiers of lipid trait genetics in the {National Health and Nutrition Examination Surveys} as part of the {Population Architecture using Genomics and Epidemiology} ({PAGE}) study.},
	volume = {131},
	year = {2012},
	bdsk-url-1 = {https://urldefense.com/v2/url?u=https-3A__pubmed.ncbi.nlm.nih.gov_22688886_&d=DwIGaQ&c=qzHnJIRvjI6L-clJH8JwLQvf_Iq43fzikf6aoxZgMb8&r=OLzLRGPbIXJFFGZfvNEKwg&m=SekvZxn15HCHj0kI8aHOjpHB1QfCfJ_plk06JUgkfzw&s=lhXjK2FC8FXFbL82dxD54MSYtNqGw3AtsT5aa5UsBWM&e= },
	bdsk-url-2 = {https://urldefense.com/v2/url?u=https-3A__doi.org_10.1007_s00439-2D012-2D1186-2Dy&d=DwIGaQ&c=qzHnJIRvjI6L-clJH8JwLQvf_Iq43fzikf6aoxZgMb8&r=OLzLRGPbIXJFFGZfvNEKwg&m=SekvZxn15HCHj0kI8aHOjpHB1QfCfJ_plk06JUgkfzw&s=rciH-V2GMBd1TSXvQvE2wqCQs4KTnpOCc7uai_sRYmc&e= }}

Downloads: 0