Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals. Dunetz, J. R., Magano, J., & Weisenburger, G. A. Organic Process Research and Development, 20(2):140–177, 2016.
doi  abstract   bibtex   
This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.
@article{dunetz_large-scale_2016,
	title = {Large-{Scale} {Applications} of {Amide} {Coupling} {Reagents} for the {Synthesis} of {Pharmaceuticals}},
	volume = {20},
	issn = {1520586X},
	doi = {10.1021/op500305s},
	abstract = {This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.},
	number = {2},
	journal = {Organic Process Research and Development},
	author = {Dunetz, Joshua R. and Magano, Javier and Weisenburger, Gerald A.},
	year = {2016},
	pages = {140--177},
}

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