Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals. Dunetz, J. R., Magano, J., & Weisenburger, G. A. Organic Process Research and Development, 20(2):140–177, 2016. doi abstract bibtex This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.
@article{dunetz_large-scale_2016,
title = {Large-{Scale} {Applications} of {Amide} {Coupling} {Reagents} for the {Synthesis} of {Pharmaceuticals}},
volume = {20},
issn = {1520586X},
doi = {10.1021/op500305s},
abstract = {This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.},
number = {2},
journal = {Organic Process Research and Development},
author = {Dunetz, Joshua R. and Magano, Javier and Weisenburger, Gerald A.},
year = {2016},
pages = {140--177},
}
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