Tocainide: a severe adverse reaction. Dunn, J M, Groth, P E, & DeSimone, A Drug Intell Clin Pharm, 22(2):142–145, 1988. Place: UNITED STATES ISBN: 0012-6578abstract bibtex Tocainide is a primary analog of lidocaine with antiarrhythmic properties used to treat ventricular rhythm disorders. A 76-year-old man with benign paroxysmal premature ventricular contractions was treated with tocainide and developed a generalized maculopapular lupoid eruption, bleeding from the lips and gingivae, vertigo, gross tremors of the extremities, fever, and short-term memory loss, which required hospitalization. The patient recovered slowly over three months with no permanent sequelae after discontinuing the drug and receiving rigorous supportive care. His excellent physical status and absence of concomitant illness contributed to an uneventful recovery. Tocainide is a potent cardioactive drug with a long biological half-life and should be used with caution.
@article{dunn_tocainide:_1988,
title = {Tocainide: a severe adverse reaction.},
volume = {22},
abstract = {Tocainide is a primary analog of lidocaine with antiarrhythmic properties used to treat ventricular rhythm disorders. A 76-year-old man with benign paroxysmal premature ventricular contractions was treated with tocainide and developed a generalized maculopapular lupoid eruption, bleeding from the lips and gingivae, vertigo, gross tremors of the extremities, fever, and short-term memory loss, which required hospitalization. The patient recovered slowly over three months with no permanent sequelae after discontinuing the drug and receiving rigorous supportive care. His excellent physical status and absence of concomitant illness contributed to an uneventful recovery. Tocainide is a potent cardioactive drug with a long biological half-life and should be used with caution.},
language = {eng},
number = {2},
journal = {Drug Intell Clin Pharm},
author = {Dunn, J M and Groth, P E and DeSimone, A},
year = {1988},
pmid = {2965003},
note = {Place: UNITED STATES
ISBN: 0012-6578},
keywords = {Aged, Anti-Arrhythmia Agents, Drug Eruptions, Drug Hypersensitivity, Humans, Lidocaine, Male, Tocainide, case reports},
pages = {142--145},
}
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