Imaging the penumbra – strategies to detect tissue at risk after ischemic stroke. Ebinger, M., De Silva, D., Christensen, S., Parsons, M., Markus, R., Donnan, G., & Davis, S. Journal of Clinical Neuroscience, 16(2):178–187, February, 2009.
Imaging the penumbra – strategies to detect tissue at risk after ischemic stroke [link]Paper  doi  abstract   bibtex   
The aim of thrombolytic therapy after acute ischemic stroke is salvage of the ischemic penumbra. Several imaging techniques have been used to identify the penumbra in patients who may benefit from reperfusion beyond the currently narrow 3-hour time-window for thrombolysis. We discuss the advantages and disadvantages of positron emission tomography (PET), single photon emission computed tomography (SPECT), MRI and CT scans. We comment on concepts of clinical-imaging mismatch models and we explore the implications for clinical trials.
@article{ebinger_imaging_2009,
	title = {Imaging the penumbra – strategies to detect tissue at risk after ischemic stroke},
	volume = {16},
	issn = {09675868},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S096758680800132X},
	doi = {10.1016/j.jocn.2008.04.002},
	abstract = {The aim of thrombolytic therapy after acute ischemic stroke is salvage of the ischemic penumbra. Several imaging techniques have been used to identify the penumbra in patients who may benefit from reperfusion beyond the currently narrow 3-hour time-window for thrombolysis. We discuss the advantages and disadvantages of positron emission tomography (PET), single photon emission computed tomography (SPECT), MRI and CT scans. We comment on concepts of clinical-imaging mismatch models and we explore the implications for clinical trials.},
	language = {en},
	number = {2},
	urldate = {2021-02-12},
	journal = {Journal of Clinical Neuroscience},
	author = {Ebinger, M. and De Silva, D.A. and Christensen, S. and Parsons, M.W. and Markus, R. and Donnan, G.A. and Davis, S.M.},
	month = feb,
	year = {2009},
	pages = {178--187},
}

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