Synchronicity of nociceptive and non-nociceptive adjacent neurons in the spinal dorsal horn of the rat: stimulus-induced plasticity. Eblen-Zajju, A. A. & Sandkuhle, J. Neuroscience, 76:39-54, 1997. abstract bibtex Universitat Heidelberg, II. Physiologisches Institut, Germany. Current knowledge of spinal processing of sensory information is largely based on single-cell recordings; however, temporal correlation of multiple cell discharges may play an important role in sensory encoding, and single electrode recordings of several neurons may provide insights into the functions of a neuronal network. The technique was applied to the lumbar spinal dorsal horn of pentobarbital-anaesthetized rats during background activity, steady-state noxious heat stimulation (48 degrees C, 100 s), cold block spinalization or radiant heat-induced inflammation of the skin, and the recordings were evaluated by means of auto-correlation, autospectral and cross-correlation analysis. Background patterns obtained by these three methods were extremely stable in time. Autocorrelation with short lag peaks was observed in 72.2% of neurons (n = 223). Background correlated discharges were found in 83.6% of the neuron pairs (n = 134). Cross-correlation with a central peak, suggestive of common input to the recorded cells, was the most common pattern observed in almost all laminae and was associated with high incidence (91.8%) of overlapping receptive fields and with neurons with initial peak autocorrelation pattern. Cross-correlations with central trough were associated with increase autocorrelation patterns. Bilateral peaks in cross-correlation, suggestive of reverberating circuitry, were observed only for pairs of neurons located in laminae IV and V and were associated with rhythmic discharges in one or in both simultaneously-recorded neurons. Lagged peaks or troughs were observed in 4.6% and 2.2% of neuronal pairs, respectively. Long-lasting skin heating induced qualitative changes (pattern changes) in the cross-correlation of 21.6% of the neuron pairs and quantitative changes in 85.7% of them. During skin inflammation qualitative changes in the cross-correlation pattern were observed in 30.8% of the neuron pairs, and quantitative changes (strength and/or synchronization time) in about 57.7% of them. Spinalization induced quantitative changes in cross-correlation in the vast majority of neuron pairs. The results of the present study suggest that discharges of neighbouring spinal dorsal horn neurons are strongly synchronized probably by propriospinal and primary afferent sources. The existence of functional reverberating circuitry was also evidenced. Finally, the functional synchronicity in the spinal dorsal horn presents stimulus-induced plasticity which consists mainly of changes on the strength and/or time of the synchronization and rarely of activation of new connectivities.
@article{ Eblen-Zajjur_Sandkuhler97,
author = {Eblen-Zajju, A. A. and Sandkuhle, J.},
title = {Synchronicity of nociceptive and non-nociceptive adjacent neurons
in the spinal dorsal horn of the rat: stimulus-induced plasticity},
journal = {Neuroscience},
year = {1997},
volume = {76},
pages = {39-54},
abstract = {Universitat Heidelberg, II. Physiologisches Institut, Germany. Current
knowledge of spinal processing of sensory information is largely
based on single-cell recordings; however, temporal correlation of
multiple cell discharges may play an important role in sensory encoding,
and single electrode recordings of several neurons may provide insights
into the functions of a neuronal network. The technique was applied
to the lumbar spinal dorsal horn of pentobarbital-anaesthetized rats
during background activity, steady-state noxious heat stimulation
(48 degrees C, 100 s), cold block spinalization or radiant heat-induced
inflammation of the skin, and the recordings were evaluated by means
of auto-correlation, autospectral and cross-correlation analysis.
Background patterns obtained by these three methods were extremely
stable in time. Autocorrelation with short lag peaks was observed
in 72.2% of neurons (n = 223). Background correlated discharges were
found in 83.6% of the neuron pairs (n = 134). Cross-correlation with
a central peak, suggestive of common input to the recorded cells,
was the most common pattern observed in almost all laminae and was
associated with high incidence (91.8%) of overlapping receptive fields
and with neurons with initial peak autocorrelation pattern. Cross-correlations
with central trough were associated with increase autocorrelation
patterns. Bilateral peaks in cross-correlation, suggestive of reverberating
circuitry, were observed only for pairs of neurons located in laminae
IV and V and were associated with rhythmic discharges in one or in
both simultaneously-recorded neurons. Lagged peaks or troughs were
observed in 4.6% and 2.2% of neuronal pairs, respectively. Long-lasting
skin heating induced qualitative changes (pattern changes) in the
cross-correlation of 21.6% of the neuron pairs and quantitative changes
in 85.7% of them. During skin inflammation qualitative changes in
the cross-correlation pattern were observed in 30.8% of the neuron
pairs, and quantitative changes (strength and/or synchronization
time) in about 57.7% of them. Spinalization induced quantitative
changes in cross-correlation in the vast majority of neuron pairs.
The results of the present study suggest that discharges of neighbouring
spinal dorsal horn neurons are strongly synchronized probably by
propriospinal and primary afferent sources. The existence of functional
reverberating circuitry was also evidenced. Finally, the functional
synchronicity in the spinal dorsal horn presents stimulus-induced
plasticity which consists mainly of changes on the strength and/or
time of the synchronization and rarely of activation of new connectivities.}
}
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{"_id":"PavCnNq8ZtGAQqve6","bibbaseid":"eblenzajju-sandkuhle-synchronicityofnociceptiveandnonnociceptiveadjacentneuronsinthespinaldorsalhornoftheratstimulusinducedplasticity-1997","downloads":0,"creationDate":"2015-02-08T05:14:42.353Z","title":"Synchronicity of nociceptive and non-nociceptive adjacent neurons in the spinal dorsal horn of the rat: stimulus-induced plasticity","author_short":["Eblen-Zajju, A.<nbsp>A.","Sandkuhle, J."],"year":1997,"bibtype":"article","biburl":"http://cnslab.mb.jhu.edu/niebase.bib","bibdata":{"abstract":"Universitat Heidelberg, II. Physiologisches Institut, Germany. Current knowledge of spinal processing of sensory information is largely based on single-cell recordings; however, temporal correlation of multiple cell discharges may play an important role in sensory encoding, and single electrode recordings of several neurons may provide insights into the functions of a neuronal network. The technique was applied to the lumbar spinal dorsal horn of pentobarbital-anaesthetized rats during background activity, steady-state noxious heat stimulation (48 degrees C, 100 s), cold block spinalization or radiant heat-induced inflammation of the skin, and the recordings were evaluated by means of auto-correlation, autospectral and cross-correlation analysis. Background patterns obtained by these three methods were extremely stable in time. Autocorrelation with short lag peaks was observed in 72.2% of neurons (n = 223). Background correlated discharges were found in 83.6% of the neuron pairs (n = 134). Cross-correlation with a central peak, suggestive of common input to the recorded cells, was the most common pattern observed in almost all laminae and was associated with high incidence (91.8%) of overlapping receptive fields and with neurons with initial peak autocorrelation pattern. Cross-correlations with central trough were associated with increase autocorrelation patterns. Bilateral peaks in cross-correlation, suggestive of reverberating circuitry, were observed only for pairs of neurons located in laminae IV and V and were associated with rhythmic discharges in one or in both simultaneously-recorded neurons. Lagged peaks or troughs were observed in 4.6% and 2.2% of neuronal pairs, respectively. Long-lasting skin heating induced qualitative changes (pattern changes) in the cross-correlation of 21.6% of the neuron pairs and quantitative changes in 85.7% of them. During skin inflammation qualitative changes in the cross-correlation pattern were observed in 30.8% of the neuron pairs, and quantitative changes (strength and/or synchronization time) in about 57.7% of them. Spinalization induced quantitative changes in cross-correlation in the vast majority of neuron pairs. The results of the present study suggest that discharges of neighbouring spinal dorsal horn neurons are strongly synchronized probably by propriospinal and primary afferent sources. The existence of functional reverberating circuitry was also evidenced. Finally, the functional synchronicity in the spinal dorsal horn presents stimulus-induced plasticity which consists mainly of changes on the strength and/or time of the synchronization and rarely of activation of new connectivities.","author":["Eblen-Zajju, A. A.","Sandkuhle, J."],"author_short":["Eblen-Zajju, A.<nbsp>A.","Sandkuhle, J."],"bibtex":"@article{ Eblen-Zajjur_Sandkuhler97,\n author = {Eblen-Zajju, A. A. and Sandkuhle, J.},\n title = {Synchronicity of nociceptive and non-nociceptive adjacent neurons\n\tin the spinal dorsal horn of the rat: stimulus-induced plasticity},\n journal = {Neuroscience},\n year = {1997},\n volume = {76},\n pages = {39-54},\n abstract = {Universitat Heidelberg, II. Physiologisches Institut, Germany. Current\n\tknowledge of spinal processing of sensory information is largely\n\tbased on single-cell recordings; however, temporal correlation of\n\tmultiple cell discharges may play an important role in sensory encoding,\n\tand single electrode recordings of several neurons may provide insights\n\tinto the functions of a neuronal network. The technique was applied\n\tto the lumbar spinal dorsal horn of pentobarbital-anaesthetized rats\n\tduring background activity, steady-state noxious heat stimulation\n\t(48 degrees C, 100 s), cold block spinalization or radiant heat-induced\n\tinflammation of the skin, and the recordings were evaluated by means\n\tof auto-correlation, autospectral and cross-correlation analysis.\n\tBackground patterns obtained by these three methods were extremely\n\tstable in time. Autocorrelation with short lag peaks was observed\n\tin 72.2% of neurons (n = 223). Background correlated discharges were\n\tfound in 83.6% of the neuron pairs (n = 134). Cross-correlation with\n\ta central peak, suggestive of common input to the recorded cells,\n\twas the most common pattern observed in almost all laminae and was\n\tassociated with high incidence (91.8%) of overlapping receptive fields\n\tand with neurons with initial peak autocorrelation pattern. Cross-correlations\n\twith central trough were associated with increase autocorrelation\n\tpatterns. Bilateral peaks in cross-correlation, suggestive of reverberating\n\tcircuitry, were observed only for pairs of neurons located in laminae\n\tIV and V and were associated with rhythmic discharges in one or in\n\tboth simultaneously-recorded neurons. Lagged peaks or troughs were\n\tobserved in 4.6% and 2.2% of neuronal pairs, respectively. Long-lasting\n\tskin heating induced qualitative changes (pattern changes) in the\n\tcross-correlation of 21.6% of the neuron pairs and quantitative changes\n\tin 85.7% of them. During skin inflammation qualitative changes in\n\tthe cross-correlation pattern were observed in 30.8% of the neuron\n\tpairs, and quantitative changes (strength and/or synchronization\n\ttime) in about 57.7% of them. Spinalization induced quantitative\n\tchanges in cross-correlation in the vast majority of neuron pairs.\n\tThe results of the present study suggest that discharges of neighbouring\n\tspinal dorsal horn neurons are strongly synchronized probably by\n\tpropriospinal and primary afferent sources. The existence of functional\n\treverberating circuitry was also evidenced. Finally, the functional\n\tsynchronicity in the spinal dorsal horn presents stimulus-induced\n\tplasticity which consists mainly of changes on the strength and/or\n\ttime of the synchronization and rarely of activation of new connectivities.}\n}","bibtype":"article","id":"Eblen-Zajjur_Sandkuhler97","journal":"Neuroscience","key":"Eblen-Zajjur_Sandkuhler97","pages":"39-54","title":"Synchronicity of nociceptive and non-nociceptive adjacent neurons in the spinal dorsal horn of the rat: stimulus-induced plasticity","type":"article","volume":"76","year":"1997","bibbaseid":"eblenzajju-sandkuhle-synchronicityofnociceptiveandnonnociceptiveadjacentneuronsinthespinaldorsalhornoftheratstimulusinducedplasticity-1997","role":"author","urls":{},"downloads":0},"search_terms":["synchronicity","nociceptive","non","nociceptive","adjacent","neurons","spinal","dorsal","horn","rat","stimulus","induced","plasticity","eblen-zajju","sandkuhle"],"keywords":[],"authorIDs":[],"dataSources":["ErLXoH8mqSjESnrN5"]}