Finite Element Simulation of a Poroelastic Model of the CSF System in the Human Brain during an Infusion Test. Eisenträger, A. Ph.D. Thesis, University of Oxford, 2012.
Finite Element Simulation of a Poroelastic Model of the CSF System in the Human Brain during an Infusion Test [link]Paper  abstract   bibtex   
Cerebrospinal fluid (CSF) fills a system of cavities at the centre of the brain, known as ventricles, and the subarachnoid space surrounding the brain and the spinal cord. In addition, CSF is in free communication with the interstitial fluid of the brain tissue. Disturbances in CSF dynamics can lead to diseases that cause severe brain damage or even death. So-called infusion tests are frequently performed in the diagnosis of such diseases. In this type of test, changes in average CSF pressure are related to changes in CSF volume through infusion of known volumes of additional fluid. Traditionally, infusion tests are analysed with single compartment models, which treat all CSF as part of one compartment and balance fluid inflow, outflow and storage through a single ordinary differential equation. Poroelastic models of the brain, on the other hand, have been used to simulate spatial changes with disease, particularly of the ventricle size, on larger time scales of days, weeks or months. Wirth and Sobey (2008) developed a two-fluid poroelastic model of the brain in which CSF pressure pulsations are linked to arterial blood pressure pulsations. In this thesis, this model is developed further and simulation results are compared to clinical data. At first, the functional form of the compliance, which governs the storage of CSF in single compartment models, is examined by comparison of two different compliance models with clinical data. The derivations of a single-fluid and a two-fluid poroelastic model of the brain in spherical symmetry are laid out in detail and some of the parameters are related to the compliance functions considered earlier. The finite element implementation of the two-fluid model is described and finally simulation results of the average CSF pressure response and the pressure pulsations are compared to clinical data.
@phdthesis{ eisentraeger2012,
  author = {Almut Eisenträger},
  title = {Finite Element Simulation of a Poroelastic Model of the CSF System
	in the Human Brain during an Infusion Test},
  school = {University of Oxford},
  year = {2012},
  abstract = {Cerebrospinal fluid (CSF) fills a system of cavities at the centre
	of the brain, known as ventricles, and the subarachnoid space surrounding
	the brain and the spinal cord. In addition, CSF is in free communication
	with the interstitial fluid of the brain tissue. Disturbances in
	CSF dynamics can lead to diseases that cause severe brain damage
	or even death. So-called infusion tests are frequently performed
	in the diagnosis of such diseases. In this type of test, changes
	in average CSF pressure are related to changes in CSF volume through
	infusion of known volumes of additional fluid.
	
	
	Traditionally, infusion tests are analysed with single compartment
	models, which treat all CSF as part of one compartment and balance
	fluid inflow, outflow and storage through a single ordinary differential
	equation. Poroelastic models of the brain, on the other hand, have
	been used to simulate spatial changes with disease, particularly
	of the ventricle size, on larger time scales of days, weeks or months.
	Wirth and Sobey (2008) developed a two-fluid poroelastic model of
	the brain in which CSF pressure pulsations are linked to arterial
	blood pressure pulsations. In this thesis, this model is developed
	further and simulation results are compared to clinical data.
	
	
	At first, the functional form of the compliance, which governs the
	storage of CSF in single compartment models, is examined by comparison
	of two different compliance models with clinical data. The derivations
	of a single-fluid and a two-fluid poroelastic model of the brain
	in spherical symmetry are laid out in detail and some of the parameters
	are related to the compliance functions considered earlier. The finite
	element implementation of the two-fluid model is described and finally
	simulation results of the average CSF pressure response and the pressure
	pulsations are compared to clinical data.},
  file = {eisentraeger2012-dphilthesisae-final2013-01-16.pdf:eisentraeger2012-dphilthesisae-final2013-01-16.pdf:PDF},
  owner = {eisentraeger},
  timestamp = {2013.01.22},
  url = {http://ora.ox.ac.uk/objects/uuid%3A372f291f-cf36-48ef-8ce8-d4c102bce9e3}
}
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