Finite Element Simulation of a Poroelastic Model of the CSF System in the Human Brain during an Infusion Test. Eisenträger, A. Ph.D. Thesis, University of Oxford, 2012. Paper abstract bibtex Cerebrospinal fluid (CSF) fills a system of cavities at the centre of the brain, known as ventricles, and the subarachnoid space surrounding the brain and the spinal cord. In addition, CSF is in free communication with the interstitial fluid of the brain tissue. Disturbances in CSF dynamics can lead to diseases that cause severe brain damage or even death. So-called infusion tests are frequently performed in the diagnosis of such diseases. In this type of test, changes in average CSF pressure are related to changes in CSF volume through infusion of known volumes of additional fluid. Traditionally, infusion tests are analysed with single compartment models, which treat all CSF as part of one compartment and balance fluid inflow, outflow and storage through a single ordinary differential equation. Poroelastic models of the brain, on the other hand, have been used to simulate spatial changes with disease, particularly of the ventricle size, on larger time scales of days, weeks or months. Wirth and Sobey (2008) developed a two-fluid poroelastic model of the brain in which CSF pressure pulsations are linked to arterial blood pressure pulsations. In this thesis, this model is developed further and simulation results are compared to clinical data. At first, the functional form of the compliance, which governs the storage of CSF in single compartment models, is examined by comparison of two different compliance models with clinical data. The derivations of a single-fluid and a two-fluid poroelastic model of the brain in spherical symmetry are laid out in detail and some of the parameters are related to the compliance functions considered earlier. The finite element implementation of the two-fluid model is described and finally simulation results of the average CSF pressure response and the pressure pulsations are compared to clinical data.
@phdthesis{ eisentraeger2012,
author = {Almut Eisenträger},
title = {Finite Element Simulation of a Poroelastic Model of the CSF System
in the Human Brain during an Infusion Test},
school = {University of Oxford},
year = {2012},
abstract = {Cerebrospinal fluid (CSF) fills a system of cavities at the centre
of the brain, known as ventricles, and the subarachnoid space surrounding
the brain and the spinal cord. In addition, CSF is in free communication
with the interstitial fluid of the brain tissue. Disturbances in
CSF dynamics can lead to diseases that cause severe brain damage
or even death. So-called infusion tests are frequently performed
in the diagnosis of such diseases. In this type of test, changes
in average CSF pressure are related to changes in CSF volume through
infusion of known volumes of additional fluid.
Traditionally, infusion tests are analysed with single compartment
models, which treat all CSF as part of one compartment and balance
fluid inflow, outflow and storage through a single ordinary differential
equation. Poroelastic models of the brain, on the other hand, have
been used to simulate spatial changes with disease, particularly
of the ventricle size, on larger time scales of days, weeks or months.
Wirth and Sobey (2008) developed a two-fluid poroelastic model of
the brain in which CSF pressure pulsations are linked to arterial
blood pressure pulsations. In this thesis, this model is developed
further and simulation results are compared to clinical data.
At first, the functional form of the compliance, which governs the
storage of CSF in single compartment models, is examined by comparison
of two different compliance models with clinical data. The derivations
of a single-fluid and a two-fluid poroelastic model of the brain
in spherical symmetry are laid out in detail and some of the parameters
are related to the compliance functions considered earlier. The finite
element implementation of the two-fluid model is described and finally
simulation results of the average CSF pressure response and the pressure
pulsations are compared to clinical data.},
file = {eisentraeger2012-dphilthesisae-final2013-01-16.pdf:eisentraeger2012-dphilthesisae-final2013-01-16.pdf:PDF},
owner = {eisentraeger},
timestamp = {2013.01.22},
url = {http://ora.ox.ac.uk/objects/uuid%3A372f291f-cf36-48ef-8ce8-d4c102bce9e3}
}
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Traditionally, infusion tests are analysed with single compartment models, which treat all CSF as part of one compartment and balance fluid inflow, outflow and storage through a single ordinary differential equation. Poroelastic models of the brain, on the other hand, have been used to simulate spatial changes with disease, particularly of the ventricle size, on larger time scales of days, weeks or months. Wirth and Sobey (2008) developed a two-fluid poroelastic model of the brain in which CSF pressure pulsations are linked to arterial blood pressure pulsations. In this thesis, this model is developed further and simulation results are compared to clinical data. At first, the functional form of the compliance, which governs the storage of CSF in single compartment models, is examined by comparison of two different compliance models with clinical data. The derivations of a single-fluid and a two-fluid poroelastic model of the brain in spherical symmetry are laid out in detail and some of the parameters are related to the compliance functions considered earlier. The finite element implementation of the two-fluid model is described and finally simulation results of the average CSF pressure response and the pressure pulsations are compared to clinical data.","author":["Eisenträger, Almut"],"author_short":["Eisenträger, A."],"bibtex":"@phdthesis{ eisentraeger2012,\n author = {Almut Eisenträger},\n title = {Finite Element Simulation of a Poroelastic Model of the CSF System\n\tin the Human Brain during an Infusion Test},\n school = {University of Oxford},\n year = {2012},\n abstract = {Cerebrospinal fluid (CSF) fills a system of cavities at the centre\n\tof the brain, known as ventricles, and the subarachnoid space surrounding\n\tthe brain and the spinal cord. In addition, CSF is in free communication\n\twith the interstitial fluid of the brain tissue. Disturbances in\n\tCSF dynamics can lead to diseases that cause severe brain damage\n\tor even death. So-called infusion tests are frequently performed\n\tin the diagnosis of such diseases. In this type of test, changes\n\tin average CSF pressure are related to changes in CSF volume through\n\tinfusion of known volumes of additional fluid.\n\t\n\t\n\tTraditionally, infusion tests are analysed with single compartment\n\tmodels, which treat all CSF as part of one compartment and balance\n\tfluid inflow, outflow and storage through a single ordinary differential\n\tequation. Poroelastic models of the brain, on the other hand, have\n\tbeen used to simulate spatial changes with disease, particularly\n\tof the ventricle size, on larger time scales of days, weeks or months.\n\tWirth and Sobey (2008) developed a two-fluid poroelastic model of\n\tthe brain in which CSF pressure pulsations are linked to arterial\n\tblood pressure pulsations. In this thesis, this model is developed\n\tfurther and simulation results are compared to clinical data.\n\t\n\t\n\tAt first, the functional form of the compliance, which governs the\n\tstorage of CSF in single compartment models, is examined by comparison\n\tof two different compliance models with clinical data. The derivations\n\tof a single-fluid and a two-fluid poroelastic model of the brain\n\tin spherical symmetry are laid out in detail and some of the parameters\n\tare related to the compliance functions considered earlier. The finite\n\telement implementation of the two-fluid model is described and finally\n\tsimulation results of the average CSF pressure response and the pressure\n\tpulsations are compared to clinical data.},\n file = {eisentraeger2012-dphilthesisae-final2013-01-16.pdf:eisentraeger2012-dphilthesisae-final2013-01-16.pdf:PDF},\n owner = {eisentraeger},\n timestamp = {2013.01.22},\n url = {http://ora.ox.ac.uk/objects/uuid%3A372f291f-cf36-48ef-8ce8-d4c102bce9e3}\n}","bibtype":"phdthesis","file":"eisentraeger2012-dphilthesisae-final2013-01-16.pdf:eisentraeger2012-dphilthesisae-final2013-01-16.pdf:PDF","id":"eisentraeger2012","key":"eisentraeger2012","owner":"eisentraeger","school":"University of Oxford","timestamp":"2013.01.22","title":"Finite Element Simulation of a Poroelastic Model of the CSF System in the Human Brain during an Infusion Test","type":"phdthesis","url":"http://ora.ox.ac.uk/objects/uuid%3A372f291f-cf36-48ef-8ce8-d4c102bce9e3","year":"2012","bibbaseid":"eisentrger-finiteelementsimulationofaporoelasticmodelofthecsfsysteminthehumanbrainduringaninfusiontest-2012","role":"author","urls":{"Paper":"http://ora.ox.ac.uk/objects/uuid%3A372f291f-cf36-48ef-8ce8-d4c102bce9e3"},"downloads":0},"bibtype":"phdthesis","biburl":"https://www.dropbox.com/s/341lf98efxtfwja/ME.bib?dl=1","creationDate":"2014-10-22T19:34:27.492Z","downloads":0,"keywords":[],"search_terms":["finite","element","simulation","poroelastic","model","csf","system","human","brain","during","infusion","test","eisenträger"],"title":"Finite Element Simulation of a Poroelastic Model of the CSF System in the Human Brain during an Infusion Test","year":2012,"dataSources":["gChqrrDiPAXSJ7jLN"]}