Cardiac MR Elastography: Comparison with left ventricular pressure measurement. Elgeti, T., Laule, M., Kaufels, N., Schnorr, J., Hamm, B., Samani, d, A., Braun, J., & Sack, I. Journal of Cardiovascular Magnetic Resonance, 2009. cited By (since 1996)18
Cardiac MR Elastography: Comparison with left ventricular pressure measurement [link]Paper  doi  abstract   bibtex   
Abstract. Purpose of study. To compare magnetic resonance elastography (MRE) with ventricular pressure changes in an animal model. Methods. Three pigs of different cardiac physiology (weight, 25 to 53 kg; heart rate, 61 to 93 bpm; left ventricular [LV] end-diastolic volume, 35 to 70 ml) were subjected to invasive LV pressure measurement by catheter and noninvasive cardiac MRE. Cardiac MRE was performed in a short-axis view of the heart and applying a 48.3-Hz shear-wave stimulus. Relative changes in LV-shear wave amplitudes during the cardiac cycle were analyzed. Correlation coefficients between wave amplitudes and LV pressure as well as between wave amplitudes and LV diameter were determined. Results. A relationship between MRE and LV pressure was observed in all three animals (R 2 0.76). No correlation was observed between MRE and LV diameter (R 2 0.15). Instead, shear wave amplitudes decreased 102 58 ms earlier than LV diameters at systole and amplitudes increased 175 40 ms before LV dilatation at diastole. Amplitude ratios between diastole and systole ranged from 2.0 to 2.8, corresponding to LV pressure differences of 60 to 73 mmHg. Conclusion. Externally induced shear waves provide information reflecting intraventricular pressure changes which, if substantiated in further experiments, has potential to make cardiac MRE a unique noninvasive imaging modality for measuring pressure-volume function of the heart. © 2009 Elgeti et al; licensee BioMed Central Ltd.
@article{ Elgeti2009,
  author = {Elgeti, T.a  and Laule, M.b  and Kaufels, N.a  and Schnorr, J.a  and Hamm, B.a  and Samani, A.c  d  and Braun, J.e  and Sack, I.a },
  title = {Cardiac MR Elastography: Comparison with left ventricular pressure measurement},
  journal = {Journal of Cardiovascular Magnetic Resonance},
  year = {2009},
  volume = {11},
  number = {1},
  art_number = {44},
  note = {cited By (since 1996)18},
  url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-74049154300&partnerID=40&md5=4c5b417b2619b4016c4e9207727d596c},
  affiliation = {Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany; Department of Medicine (Cardiology, Angiology, Pulmonology), Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Medical Biophysics, University of Western Ontario, ON, Canada; Department of Electrical and Computer Engineering, University of Western Ontario, ON, Canada; Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany},
  abstract = {Abstract. Purpose of study. To compare magnetic resonance elastography (MRE) with ventricular pressure changes in an animal model. Methods. Three pigs of different cardiac physiology (weight, 25 to 53 kg; heart rate, 61 to 93 bpm; left ventricular [LV] end-diastolic volume, 35 to 70 ml) were subjected to invasive LV pressure measurement by catheter and noninvasive cardiac MRE. Cardiac MRE was performed in a short-axis view of the heart and applying a 48.3-Hz shear-wave stimulus. Relative changes in LV-shear wave amplitudes during the cardiac cycle were analyzed. Correlation coefficients between wave amplitudes and LV pressure as well as between wave amplitudes and LV diameter were determined. Results. A relationship between MRE and LV pressure was observed in all three animals (R 2 0.76). No correlation was observed between MRE and LV diameter (R 2 0.15). Instead, shear wave amplitudes decreased 102 58 ms earlier than LV diameters at systole and amplitudes increased 175 40 ms before LV dilatation at diastole. Amplitude ratios between diastole and systole ranged from 2.0 to 2.8, corresponding to LV pressure differences of 60 to 73 mmHg. Conclusion. Externally induced shear waves provide information reflecting intraventricular pressure changes which, if substantiated in further experiments, has potential to make cardiac MRE a unique noninvasive imaging modality for measuring pressure-volume function of the heart. © 2009 Elgeti et al; licensee BioMed Central Ltd.},
  keywords = {animal experiment;  animal tissue;  article;  blood pressure measurement;  cardiovascular system examination;  comparative study;  controlled study;  correlation coefficient;  elastography;  heart catheter;  heart cycle;  heart left ventricle enddiastolic volume;  heart left ventricle function;  heart left ventricle pressure;  heart rate;  magnetic resonance elastography;  manometer;  non invasive procedure;  nonhuman;  nuclear magnetic resonance imaging;  nuclear magnetic resonance scanner;  priority journal;  swine;  animal;  animal model;  heart catheterization;  heart ventricle pressure;  minipig;  prediction and forecasting;  time, Animals;  Elasticity Imaging Techniques;  Heart Catheterization;  Magnetic Resonance Imaging, Cine;  Models, Animal;  Predictive Value of Tests;  Swine;  Swine, Miniature;  Time Factors;  Ventricular Function, Left;  Ventricular Pressure},
  tradenames = {Magnetom Sonata, Siemens},
  manufacturers = {Siemens},
  references = {Sengupta, P.P., Krishnamoorthy, V.K., Korinek, J., Narula, J., Vannan, M.A., Lester, S.J., Tajik, J.A., Belohlavek, M., Left ventricular form and function revisited: Applied translational science to cardiovascular ultrasound imaging (2007) J Am Soc Echocardiogr, 20 (5), pp. 539-551. , 17485001. 10.1016/j.echo.2006.10.013; Axel, L., Biomechanical dynamics of the heart with MRI (2002) Annu Rev Biomed Eng, 4, pp. 321-347. , 10.1146/annurev.bioeng.4.020702.153434. 12117761; Finn, J.P., Nael, K., Deshpande, V., Ratib, O., Laub, G., Cardiac MR imaging: State of the technology (2006) Radiology, 241 (2), pp. 338-354. , 10.1148/radiol.2412041866. 17057063; Beek, A.M., Bondarenko, O., Afsharzada, F., Van Rossum, A.C., Quantification of late gadolinium enhanced CMR in viability assessment in chronic ischemic heart disease: A comparison to functional outcome (2009) J Cardiovasc Magn Reson, 11 (1), p. 6. , 19272147. 10.1186/1532-429X-11-6; Kass, D.A., Assessment of diastolic dysfunction. Invasive modalities (2000) Cardiol Clin, 18 (3), pp. 571-586. , 10.1016/S0733-8651(05)70162-4. 10986590; Strobeck, J.E., Sonnenblick, E.H., Myocardial and ventricular function. Part II: Intact heart (1981) Herz, 6 (5), pp. 275-287. , 7298007; Mandinov, L., Eberli, F.R., Seiler, C., Hess, O.M., Diastolic heart failure (2000) Cardiovasc Res, 45 (4), pp. 813-825. , 10.1016/S0008-6363(99)00399-5. 10728407; Muthupillai, R., Lomas, D.J., Rossman, P.J., Greenleaf, J.F., Manduca, A., Ehman, R.L., Magnetic resonance elastography by direct visualization of propagating acoustic strain waves (1995) Science, 269 (5232), pp. 1854-1857. , 10.1126/science.7569924. 7569924; Rump, J., Klatt, D., Braun, J., Warmuth, C., Sack, I., Fractional encoding of harmonic motions in MR elastography (2007) Magn Reson Med, 57 (2), pp. 388-395. , 10.1002/mrm.21152. 17260354; Elgeti, T., Rump, J., Hamhaber, U., Papazoglou, S., Hamm, B., Braun, J., Sack, I., Cardiac magnetic resonance elastography. Initial results (2008) Invest Radiol, 43 (11), pp. 762-772. , 10.1097/RLI.0b013e3181822085. 18923255; Sack, I., Rump, J., Elgeti, T., Samani, A., Braun, J., MR elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations (2009) Magn Reson Med, 61 (3), pp. 668-677. , 10.1002/mrm.21878. 19097236; Klatt, D., Asbach, P., Rump, J., Papazoglou, S., Somasundaram, R., Modrow, J., Braun, J., Sack, I., In vivo determination of hepatic stiffness using steady-state free precession magnetic resonance elastography (2006) Invest Radiol, 41 (12), pp. 841-848. , 10.1097/01.rli.0000244341.16372.08. 17099421; Papazoglou, S., Xu, C., Hamhaber, U., Siebert, E., Bohner, G., Klingebiel, R., Braun, J., Sack, I., Scatter-based magnetic resonance elastography (2009) Phys Med Biol, 54 (7), pp. 2229-2241. , 10.1088/0031-9155/54/7/025. 19293467; Burkhoff, D., Mirsky, I., Suga, H., Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: A guide for clinical, translational, and basic researchers (2005) Am J Physiol Heart Circ Physiol, 289 (2), pp. 8501-512. , 10.1152/ajpheart.00138.2005. 16014610; Magorien, D.J., Shaffer, P., Bush, C.A., Magorien, R.D., Kolibash, A.J., Leier, C.V., Bashore, T.M., Assessment of left ventricular pressure-volume relations using gated radionuclide angiography, echocardiography, and micromanometer pressure recordings. A new method for serial measurements of systolic and diastolic function in man (1983) Circulation, 67 (4), pp. 844-853. , 6825238; Oh, J.K., Tajik, J., The return of cardiac time intervals: The phoenix is rising (2003) J Am Coll Cardiol, 42 (8), pp. 1471-1474. , 10.1016/S0735-1097(03)01036-2. 14563594},
  correspondence_address1 = {Elgeti, T.; Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany; email: thomas.elgeti@charite.de},
  issn = {10976647},
  coden = {JCMRF},
  doi = {10.1186/1532-429X-11-44},
  language = {English},
  abbrev_source_title = {J. Cardiovasc. Magn. Reson.},
  document_type = {Article},
  source = {Scopus}
}

Downloads: 0