@article{ el-hage_bdnf_2014,
  title = {The {BDNF} Val(66)Met polymorphism is associated with escitalopram response in depressed patients},
  issn = {1432-2072},
  doi = {10.1007/s00213-014-3694-z},
  abstract = {{BACKGROUND}: The brain-derived neurotrophic factor ({BDNF}) gene is a candidate gene in therapeutic responses to antidepressants. The aim of the study was to determine the effects of {BDNF} allelic variability on responses to escitalopram treatment at 3 weeks after treatment initiation and at a 6-week endpoint.
{METHODS}: We included 187 Caucasian subjects with depression; 153 completed the 6-week study. Clinical evaluation was performed using the Montgomery and Asberg Depression Rating Scale ({MADRS}) before and after 3-6 weeks of treatment.
{RESULTS}: After 3 weeks of treatment, we saw significantly better treatment responses in the Met carriers and greater antidepressant resistance among the Val/Val homozygotes. Relative to Val/Val homozygous (59.78 %), a significantly greater proportion of subjects Met-carriers (77.94 %) responded to escitalopram treatment (χ (2) = 5.88, p = 0.015). After 6 weeks, we found the same pattern of results but this effect did not reach statistical significance (χ (2) = 2.07, p = 0.15).
{CONCLUSION}: These findings highlight a significant association between the {BDNF} valine to methionine substitution (Val(66)Met) polymorphism and the treatment response to escitalopram in a Caucasian population of severely depressed inpatients.},
  language = {{ENG}},
  journal = {Psychopharmacology},
  author = {El-Hage, Wissam and Vourc'h, Patrick and Gaillard, Philippe and Léger, Julie and Belzung, Catherine and Ibarguen-Vargas, Yadira and Andres, Christian R. and Camus, Vincent},
  month = {July},
  year = {2014},
  pmid = {25074447}
}

{"_id":"5YjDQcSiiEniLddQm","authorIDs":[],"author_short":["El-Hage, W.","Vourc'h, P.","Gaillard, P.","Léger, J.","Belzung, C.","Ibarguen-Vargas, Y.","Andres, C.<nbsp>R.","Camus, V."],"bibbaseid":"elhage-vourch-gaillard-lger-belzung-ibarguenvargas-andres-camus-thebdnfval66metpolymorphismisassociatedwithescitalopramresponseindepressedpatients-2014","bibdata":{"abstract":"BACKGROUND: The brain-derived neurotrophic factor (BDNF) gene is a candidate gene in therapeutic responses to antidepressants. The aim of the study was to determine the effects of BDNF allelic variability on responses to escitalopram treatment at 3 weeks after treatment initiation and at a 6-week endpoint. METHODS: We included 187 Caucasian subjects with depression; 153 completed the 6-week study. Clinical evaluation was performed using the Montgomery and Asberg Depression Rating Scale (MADRS) before and after 3-6 weeks of treatment. RESULTS: After 3 weeks of treatment, we saw significantly better treatment responses in the Met carriers and greater antidepressant resistance among the Val/Val homozygotes. Relative to Val/Val homozygous (59.78 %), a significantly greater proportion of subjects Met-carriers (77.94 %) responded to escitalopram treatment (χ (2) = 5.88, p = 0.015). After 6 weeks, we found the same pattern of results but this effect did not reach statistical significance (χ (2) = 2.07, p = 0.15). CONCLUSION: These findings highlight a significant association between the BDNF valine to methionine substitution (Val(66)Met) polymorphism and the treatment response to escitalopram in a Caucasian population of severely depressed inpatients.","author":["El-Hage, Wissam","Vourc'h, Patrick","Gaillard, Philippe","Léger, Julie","Belzung, Catherine","Ibarguen-Vargas, Yadira","Andres, Christian R.","Camus, Vincent"],"author_short":["El-Hage, W.","Vourc'h, P.","Gaillard, P.","Léger, J.","Belzung, C.","Ibarguen-Vargas, Y.","Andres, C.<nbsp>R.","Camus, V."],"bibtex":"@article{ el-hage_bdnf_2014,\n title = {The {BDNF} Val(66)Met polymorphism is associated with escitalopram response in depressed patients},\n issn = {1432-2072},\n doi = {10.1007/s00213-014-3694-z},\n abstract = {{BACKGROUND}: The brain-derived neurotrophic factor ({BDNF}) gene is a candidate gene in therapeutic responses to antidepressants. The aim of the study was to determine the effects of {BDNF} allelic variability on responses to escitalopram treatment at 3 weeks after treatment initiation and at a 6-week endpoint.\n{METHODS}: We included 187 Caucasian subjects with depression; 153 completed the 6-week study. Clinical evaluation was performed using the Montgomery and Asberg Depression Rating Scale ({MADRS}) before and after 3-6 weeks of treatment.\n{RESULTS}: After 3 weeks of treatment, we saw significantly better treatment responses in the Met carriers and greater antidepressant resistance among the Val/Val homozygotes. Relative to Val/Val homozygous (59.78 %), a significantly greater proportion of subjects Met-carriers (77.94 %) responded to escitalopram treatment (χ (2) = 5.88, p = 0.015). After 6 weeks, we found the same pattern of results but this effect did not reach statistical significance (χ (2) = 2.07, p = 0.15).\n{CONCLUSION}: These findings highlight a significant association between the {BDNF} valine to methionine substitution (Val(66)Met) polymorphism and the treatment response to escitalopram in a Caucasian population of severely depressed inpatients.},\n language = {{ENG}},\n journal = {Psychopharmacology},\n author = {El-Hage, Wissam and Vourc'h, Patrick and Gaillard, Philippe and Léger, Julie and Belzung, Catherine and Ibarguen-Vargas, Yadira and Andres, Christian R. and Camus, Vincent},\n month = {July},\n year = {2014},\n pmid = {25074447}\n}","bibtype":"article","doi":"10.1007/s00213-014-3694-z","id":"el-hage_bdnf_2014","issn":"1432-2072","journal":"Psychopharmacology","key":"el-hage_bdnf_2014","language":"ENG","month":"July","pmid":"25074447","title":"The BDNF Val(66)Met polymorphism is associated with escitalopram response in depressed patients","type":"article","year":"2014","bibbaseid":"elhage-vourch-gaillard-lger-belzung-ibarguenvargas-andres-camus-thebdnfval66metpolymorphismisassociatedwithescitalopramresponseindepressedpatients-2014","role":"author","urls":{},"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/brizard","creationDate":"2015-02-11T09:04:28.449Z","downloads":0,"keywords":[],"search_terms":["bdnf","val","met","polymorphism","associated","escitalopram","response","depressed","patients","el-hage","vourc'h","gaillard","léger","belzung","ibarguen-vargas","andres","camus"],"title":"The BDNF Val(66)Met polymorphism is associated with escitalopram response in depressed patients","year":2014,"dataSources":["H9yznXMN7R8ae2jTA"]}