@ARTICLE{Elias2008-op,
  title    = "Differential trafficking of {AMPA} and {NMDA} receptors by
              {SAP102} and {PSD-95} underlies synapse development",
  author   = "Elias, G M and Elias, L A B and Apostolides, P F and Kriegstein,
              A R and Nicoll, R A",
  abstract = "The development of glutamatergic synapses involves changes in the
              number and type of receptors present at the postsynaptic density.
              To elucidate molecular mechanisms underlying these changes, we
              combine in utero electroporation of constructs that alter the
              molecular composition of developing synapses with dual whole-cell
              electrophysiology to examine synaptic transmission during two
              distinct developmental stages. We find that SAP102 mediates
              synaptic trafficking of AMPA and NMDA receptors during
              synaptogenesis. Surprisingly, after synaptogenesis, PSD-95
              assumes the functions of SAP102 and is necessary for two aspects
              of synapse maturation: the developmental increase in AMPA
              receptor transmission and replacement of NR2B-NMDARs with
              NR2A-NMDARs. In PSD-95/PSD-93 double-KO mice, the maturational
              replacement of NR2B- with NR2A-NMDARs fails to occur, and PSD-95
              expression fully rescues this deficit. This study demonstrates
              that SAP102 and PSD-95 regulate the synaptic trafficking of
              distinct glutamate receptor subtypes at different developmental
              stages, thereby playing necessary roles in excitatory synapse
              development.",
  journal  = "Proc Natl Acad Sci U S A",
  volume   =  105,
  number   =  52,
  pages    = "20953--20958",
  month    =  dec,
  year     =  2008,
  language = "en"
}

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