@ARTICLE{Elias2010-st,
  title    = "Connexin 43 mediates the tangential to radial migratory switch in
              ventrally derived cortical interneurons",
  author   = "Elias, Laura A B and Turmaine, Mark and Parnavelas, John G and
              Kriegstein, Arnold R",
  abstract = "The adult cerebral cortex is composed of excitatory and
              inhibitory neurons that arise from progenitor cells in disparate
              proliferative regions in the developing brain and follow
              different migratory paths. Excitatory pyramidal neurons originate
              near the ventricle and migrate radially to their position in the
              cortical plate along radial glial fibers. On the other hand,
              inhibitory interneurons arise in the ventral telencephalon and
              migrate tangentially to enter the developing cortex before
              migrating radially to reach their correct laminar position. Gap
              junction adhesion has been shown to play an important mechanistic
              role in the radial migration of excitatory neurons. We asked
              whether a similar mechanism governs the tangential or radial
              migration of inhibitory interneurons. Using short hairpin RNA
              knockdown of Connexin 43 (Cx43) and Cx26 together with rescue
              experiments, we found that gap junctions are dispensable for the
              tangential migration of interneurons, but that Cx43 plays a role
              in the switch from tangential to radial migration that allows
              interneurons to enter the cortical plate and find their correct
              laminar position. Moreover this action is dependent on the
              adhesive properties and the C terminus of Cx43 but not the Cx43
              channel. Thus, the radial phase of interneuron migration
              resembles that of excitatory neuron migration in terms of
              dependence on Cx43 adhesion. Furthermore, gap junctions between
              migrating interneurons and radial processes were observed by
              electron microscopy. These findings provide mechanistic and
              structural support for a gap junction-mediated interaction
              between migrating interneurons and radial glia during the switch
              from tangential to radial migration.",
  journal  = "J Neurosci",
  volume   =  30,
  number   =  20,
  pages    = "7072--7077",
  month    =  may,
  year     =  2010,
  language = "en"
}

{"_id":"Ranm5Gc8SQjxd4wwr","bibbaseid":"elias-turmaine-parnavelas-kriegstein-connexin43mediatesthetangentialtoradialmigratoryswitchinventrallyderivedcorticalinterneurons-2010","author_short":["Elias, L. A B","Turmaine, M.","Parnavelas, J. G","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons","author":[{"propositions":[],"lastnames":["Elias"],"firstnames":["Laura","A","B"],"suffixes":[]},{"propositions":[],"lastnames":["Turmaine"],"firstnames":["Mark"],"suffixes":[]},{"propositions":[],"lastnames":["Parnavelas"],"firstnames":["John","G"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"The adult cerebral cortex is composed of excitatory and inhibitory neurons that arise from progenitor cells in disparate proliferative regions in the developing brain and follow different migratory paths. Excitatory pyramidal neurons originate near the ventricle and migrate radially to their position in the cortical plate along radial glial fibers. On the other hand, inhibitory interneurons arise in the ventral telencephalon and migrate tangentially to enter the developing cortex before migrating radially to reach their correct laminar position. Gap junction adhesion has been shown to play an important mechanistic role in the radial migration of excitatory neurons. We asked whether a similar mechanism governs the tangential or radial migration of inhibitory interneurons. Using short hairpin RNA knockdown of Connexin 43 (Cx43) and Cx26 together with rescue experiments, we found that gap junctions are dispensable for the tangential migration of interneurons, but that Cx43 plays a role in the switch from tangential to radial migration that allows interneurons to enter the cortical plate and find their correct laminar position. Moreover this action is dependent on the adhesive properties and the C terminus of Cx43 but not the Cx43 channel. Thus, the radial phase of interneuron migration resembles that of excitatory neuron migration in terms of dependence on Cx43 adhesion. Furthermore, gap junctions between migrating interneurons and radial processes were observed by electron microscopy. These findings provide mechanistic and structural support for a gap junction-mediated interaction between migrating interneurons and radial glia during the switch from tangential to radial migration.","journal":"J Neurosci","volume":"30","number":"20","pages":"7072–7077","month":"May","year":"2010","language":"en","bibtex":"@ARTICLE{Elias2010-st,\n title = \"Connexin 43 mediates the tangential to radial migratory switch in\n ventrally derived cortical interneurons\",\n author = \"Elias, Laura A B and Turmaine, Mark and Parnavelas, John G and\n Kriegstein, Arnold R\",\n abstract = \"The adult cerebral cortex is composed of excitatory and\n inhibitory neurons that arise from progenitor cells in disparate\n proliferative regions in the developing brain and follow\n different migratory paths. Excitatory pyramidal neurons originate\n near the ventricle and migrate radially to their position in the\n cortical plate along radial glial fibers. On the other hand,\n inhibitory interneurons arise in the ventral telencephalon and\n migrate tangentially to enter the developing cortex before\n migrating radially to reach their correct laminar position. Gap\n junction adhesion has been shown to play an important mechanistic\n role in the radial migration of excitatory neurons. We asked\n whether a similar mechanism governs the tangential or radial\n migration of inhibitory interneurons. Using short hairpin RNA\n knockdown of Connexin 43 (Cx43) and Cx26 together with rescue\n experiments, we found that gap junctions are dispensable for the\n tangential migration of interneurons, but that Cx43 plays a role\n in the switch from tangential to radial migration that allows\n interneurons to enter the cortical plate and find their correct\n laminar position. Moreover this action is dependent on the\n adhesive properties and the C terminus of Cx43 but not the Cx43\n channel. Thus, the radial phase of interneuron migration\n resembles that of excitatory neuron migration in terms of\n dependence on Cx43 adhesion. Furthermore, gap junctions between\n migrating interneurons and radial processes were observed by\n electron microscopy. These findings provide mechanistic and\n structural support for a gap junction-mediated interaction\n between migrating interneurons and radial glia during the switch\n from tangential to radial migration.\",\n journal = \"J Neurosci\",\n volume = 30,\n number = 20,\n pages = \"7072--7077\",\n month = may,\n year = 2010,\n language = \"en\"\n}\n\n","author_short":["Elias, L. A B","Turmaine, M.","Parnavelas, J. G","Kriegstein, A. R"],"key":"Elias2010-st","id":"Elias2010-st","bibbaseid":"elias-turmaine-parnavelas-kriegstein-connexin43mediatesthetangentialtoradialmigratoryswitchinventrallyderivedcorticalinterneurons-2010","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["connexin","mediates","tangential","radial","migratory","switch","ventrally","derived","cortical","interneurons","elias","turmaine","parnavelas","kriegstein"],"title":"Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons","year":2010}