@ARTICLE{Elias2007-ms,
  title    = "Gap junction adhesion is necessary for radial migration in the
              neocortex",
  author   = "Elias, Laura A B and Wang, Doris D and Kriegstein, Arnold R",
  abstract = "Radial glia, the neuronal stem cells of the embryonic cerebral
              cortex, reside deep within the developing brain and extend radial
              fibres to the pial surface, along which embryonic neurons migrate
              to reach the cortical plate. Here we show that the gap junction
              subunits connexin 26 (Cx26) and connexin 43 (Cx43) are expressed
              at the contact points between radial fibres and migrating
              neurons, and acute downregulation of Cx26 or Cx43 impairs the
              migration of neurons to the cortical plate. Unexpectedly, gap
              junctions do not mediate neuronal migration by acting in the
              classical manner to provide an aqueous channel for cell-cell
              communication. Instead, gap junctions provide dynamic adhesive
              contacts that interact with the internal cytoskeleton to enable
              leading process stabilization along radial fibres as well as the
              subsequent translocation of the nucleus. These results indicate
              that gap junction adhesions are necessary for glial-guided
              neuronal migration, raising the possibility that the adhesive
              properties of gap junctions may have an important role in other
              physiological processes and diseases associated with gap junction
              function.",
  journal  = "Nature",
  volume   =  448,
  number   =  7156,
  pages    = "901--907",
  month    =  aug,
  year     =  2007,
  address  = "England",
  language = "en"
}

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