@article{RN230,
   author = {Ellis, T. L. and Garcia, P. A. and Rossmeisl, J. H., Jr. and Henao-Guerrero, N. and Robertson, J. and Davalos, R. V.},
   title = {Nonthermal irreversible electroporation for intracranial surgical applications. Laboratory investigation},
   journal = {J Neurosurg},
   volume = {114},
   number = {3},
   pages = {681-8},
   note = {1933-0693
Ellis, Thomas L
Garcia, Paulo A
Rossmeisl, John H Jr
Henao-Guerrero, Natalia
Robertson, John
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
United States
2010/06/22
J Neurosurg. 2011 Mar;114(3):681-8. doi: 10.3171/2010.5.JNS091448. Epub 2010 Jun 18.},
   abstract = {OBJECT: Nonthermal irreversible electroporation (NTIRE) is a novel, minimally invasive technique to treat cancer, which is unique because of its nonthermal mechanism of tumor ablation. This paper evaluates the safety of an NTIRE procedure to lesion normal canine brain tissue. METHODS: The NTIRE procedure involved placing electrodes into a targeted area of brain in 3 dogs and delivering a series of short and intense electric pulses. The voltages of the pulses applied were varied between dogs. Another dog was used as a sham control. One additional dog was treated at an extreme voltage to determine the upper safety limits of the procedure. Ultrasonography was used at the time of the procedure to determine if the lesions could be visualized intraoperatively. The volumes of ablated tissue were then estimated on postprocedure MR imaging. Histological brain sections were then analyzed to evaluate the lesions produced. RESULTS: The animals tolerated the procedure with no apparent complications except for the animal that was treated at the upper voltage limit. The lesion volume appeared to decrease with decreasing voltage of applied pulses. Histological examination revealed cell death within the treated volume with a submillimeter transition zone between necrotic and normal brain. CONCLUSIONS: The authors' results reveal that NTIRE at selected voltages can be safely administered in normal canine brain and that the volume of ablated tissue correlates with the voltage of the applied pulses. This preliminary study is the first step toward using NTIRE as a brain cancer treatment.},
   keywords = {Algorithms
Animals
Brain/*surgery
Brain Neoplasms
Cell Death
Cell Membrane/physiology/ultrastructure
Dogs
Electric Stimulation
Electrodes, Implanted
Electroporation/*methods
Magnetic Resonance Imaging
Necrosis
Neurosurgical Procedures/adverse effects/*methods
Pilot Projects},
   ISSN = {0022-3085},
   DOI = {10.3171/2010.5.Jns091448},
   year = {2011},
   type = {Journal Article}
}

{"_id":"EMoLaLTijyhbTr3Zx","bibbaseid":"ellis-garcia-rossmeisl-henaoguerrero-robertson-davalos-nonthermalirreversibleelectroporationforintracranialsurgicalapplicationslaboratoryinvestigation-2011","author_short":["Ellis, T. L.","Garcia, P. A.","Rossmeisl, J. H.","Henao-Guerrero, N.","Robertson, J.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Ellis"],"firstnames":["T.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Garcia"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Rossmeisl"],"firstnames":["J.","H."],"suffixes":["Jr."]},{"propositions":[],"lastnames":["Henao-Guerrero"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Robertson"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Nonthermal irreversible electroporation for intracranial surgical applications. Laboratory investigation","journal":"J Neurosurg","volume":"114","number":"3","pages":"681-8","note":"1933-0693 Ellis, Thomas L Garcia, Paulo A Rossmeisl, John H Jr Henao-Guerrero, Natalia Robertson, John Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't United States 2010/06/22 J Neurosurg. 2011 Mar;114(3):681-8. doi: 10.3171/2010.5.JNS091448. Epub 2010 Jun 18.","abstract":"OBJECT: Nonthermal irreversible electroporation (NTIRE) is a novel, minimally invasive technique to treat cancer, which is unique because of its nonthermal mechanism of tumor ablation. This paper evaluates the safety of an NTIRE procedure to lesion normal canine brain tissue. METHODS: The NTIRE procedure involved placing electrodes into a targeted area of brain in 3 dogs and delivering a series of short and intense electric pulses. The voltages of the pulses applied were varied between dogs. Another dog was used as a sham control. One additional dog was treated at an extreme voltage to determine the upper safety limits of the procedure. Ultrasonography was used at the time of the procedure to determine if the lesions could be visualized intraoperatively. The volumes of ablated tissue were then estimated on postprocedure MR imaging. Histological brain sections were then analyzed to evaluate the lesions produced. RESULTS: The animals tolerated the procedure with no apparent complications except for the animal that was treated at the upper voltage limit. The lesion volume appeared to decrease with decreasing voltage of applied pulses. Histological examination revealed cell death within the treated volume with a submillimeter transition zone between necrotic and normal brain. CONCLUSIONS: The authors' results reveal that NTIRE at selected voltages can be safely administered in normal canine brain and that the volume of ablated tissue correlates with the voltage of the applied pulses. This preliminary study is the first step toward using NTIRE as a brain cancer treatment.","keywords":"Algorithms Animals Brain/*surgery Brain Neoplasms Cell Death Cell Membrane/physiology/ultrastructure Dogs Electric Stimulation Electrodes, Implanted Electroporation/*methods Magnetic Resonance Imaging Necrosis Neurosurgical Procedures/adverse effects/*methods Pilot Projects","issn":"0022-3085","doi":"10.3171/2010.5.Jns091448","year":"2011","bibtex":"@article{RN230,\n author = {Ellis, T. L. and Garcia, P. A. and Rossmeisl, J. H., Jr. and Henao-Guerrero, N. and Robertson, J. and Davalos, R. V.},\n title = {Nonthermal irreversible electroporation for intracranial surgical applications. Laboratory investigation},\n journal = {J Neurosurg},\n volume = {114},\n number = {3},\n pages = {681-8},\n note = {1933-0693\nEllis, Thomas L\nGarcia, Paulo A\nRossmeisl, John H Jr\nHenao-Guerrero, Natalia\nRobertson, John\nDavalos, Rafael V\nJournal Article\nResearch Support, Non-U.S. Gov't\nUnited States\n2010/06/22\nJ Neurosurg. 2011 Mar;114(3):681-8. doi: 10.3171/2010.5.JNS091448. Epub 2010 Jun 18.},\n abstract = {OBJECT: Nonthermal irreversible electroporation (NTIRE) is a novel, minimally invasive technique to treat cancer, which is unique because of its nonthermal mechanism of tumor ablation. This paper evaluates the safety of an NTIRE procedure to lesion normal canine brain tissue. METHODS: The NTIRE procedure involved placing electrodes into a targeted area of brain in 3 dogs and delivering a series of short and intense electric pulses. The voltages of the pulses applied were varied between dogs. Another dog was used as a sham control. One additional dog was treated at an extreme voltage to determine the upper safety limits of the procedure. Ultrasonography was used at the time of the procedure to determine if the lesions could be visualized intraoperatively. The volumes of ablated tissue were then estimated on postprocedure MR imaging. Histological brain sections were then analyzed to evaluate the lesions produced. RESULTS: The animals tolerated the procedure with no apparent complications except for the animal that was treated at the upper voltage limit. The lesion volume appeared to decrease with decreasing voltage of applied pulses. Histological examination revealed cell death within the treated volume with a submillimeter transition zone between necrotic and normal brain. CONCLUSIONS: The authors' results reveal that NTIRE at selected voltages can be safely administered in normal canine brain and that the volume of ablated tissue correlates with the voltage of the applied pulses. 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V."],"key":"RN230","id":"RN230","bibbaseid":"ellis-garcia-rossmeisl-henaoguerrero-robertson-davalos-nonthermalirreversibleelectroporationforintracranialsurgicalapplicationslaboratoryinvestigation-2011","role":"author","urls":{},"keyword":["Algorithms Animals Brain/*surgery Brain Neoplasms Cell Death Cell Membrane/physiology/ultrastructure Dogs Electric Stimulation Electrodes","Implanted Electroporation/*methods Magnetic Resonance Imaging Necrosis Neurosurgical Procedures/adverse effects/*methods Pilot Projects"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["algorithms animals brain/*surgery brain neoplasms cell death cell membrane/physiology/ultrastructure dogs electric stimulation electrodes","implanted electroporation/*methods magnetic resonance imaging necrosis neurosurgical procedures/adverse effects/*methods pilot projects"],"search_terms":["nonthermal","irreversible","electroporation","intracranial","surgical","applications","laboratory","investigation","ellis","garcia","rossmeisl","henao-guerrero","robertson","davalos"],"title":"Nonthermal irreversible electroporation for intracranial surgical applications. Laboratory investigation","year":2011}