Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase. El Sahly, H. M, Baden, L. R, Essink, B., Doblecki-Lewis, S., Martin, J. M, Anderson, E. J, Campbell, T. B, Clark, J., Jackson, L. A, Fichtenbaum, C. J, Zervos, M., Rankin, B., Eder, F., Feldman, G., Kennelly, C., Han-Conrad, L., Levin, M., Neuzil, K. M, Corey, L., Gilbert, P., Janes, H., Follmann, D., Marovich, M., Polakowski, L., Mascola, J. R, Ledgerwood, J. E, Graham, B. S, August, A., Clouting, H., Deng, W., Han, S., Leav, B., Manzo, D., Pajon, R., Schödel, F., Tomassini, J. E, Zhou, H., & Miller, J. The New England journal of medicine, 385(19):1774-1785, Massachusetts Medical Society, United States, 2021. abstract bibtex The mRNA-1273 vaccine was approved for emergency use in December 2020; trial participants who received placebo were informed of the results and offered vaccination. At the close of the blinded phase of the trial, the vaccine efficacy in preventing Covid-19 illness was 93.2%, and the efficacy against severe disease was 98.2%. No new safety issues were identified.
@article{ElSahlyHanaM2021Eotm,
abstract = {The mRNA-1273 vaccine was approved for emergency use in December 2020; trial participants who received placebo were informed of the results and offered vaccination. At the close of the blinded phase of the trial, the vaccine efficacy in preventing Covid-19 illness was 93.2%, and the efficacy against severe disease was 98.2%. No new safety issues were identified.},
author = {El Sahly, Hana M and Baden, Lindsey R and Essink, Brandon and Doblecki-Lewis, Susanne and Martin, Judith M and Anderson, Evan J and Campbell, Thomas B and Clark, Jesse and Jackson, Lisa A and Fichtenbaum, Carl J and Zervos, Marcus and Rankin, Bruce and Eder, Frank and Feldman, Gregory and Kennelly, Christina and Han-Conrad, Laurie and Levin, Michael and Neuzil, Kathleen M and Corey, Lawrence and Gilbert, Peter and Janes, Holly and Follmann, Dean and Marovich, Mary and Polakowski, Laura and Mascola, John R and Ledgerwood, Julie E and Graham, Barney S and August, Allison and Clouting, Heather and Deng, Weiping and Han, Shu and Leav, Brett and Manzo, Deb and Pajon, Rolando and Schödel, Florian and Tomassini, Joanne E and Zhou, Honghong and Miller, Jacqueline},
address = {United States},
copyright = {Copyright © 2021 Massachusetts Medical Society. All rights reserved.},
issn = {0028-4793},
journal = {The New England journal of medicine},
keywords = {2019-nCoV Vaccine mRNA-1273 ; Adolescent ; Adult ; Aged ; Asymptomatic ; Asymptomatic infection ; Clinical trials ; Consent ; Coronavirus ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - prevention & control ; COVID-19 vaccines ; COVID-19 Vaccines - adverse effects ; COVID-19 Vaccines - immunology ; Follow-Up Studies ; Humans ; Hypersensitivity ; Immunization ; Immunization, Secondary ; Immunogenicity, Vaccine ; Incidence ; Infections ; Infectious Disease ; Infectious diseases ; Injection ; Injections ; Intention to Treat Analysis ; Male ; Middle Aged ; mRNA ; Original ; Patient Acuity ; Placebos ; Population ; Safety ; Severe acute respiratory syndrome coronavirus 2 ; Single-Blind Method ; Statistical analysis ; Treatment Outcome ; Vaccine efficacy ; Vaccines ; Young Adult},
language = {eng},
number = {19},
organization = {COVE Study Group},
pages = {1774-1785},
publisher = {Massachusetts Medical Society},
title = {Efficacy of the {mRNA-1273 SARS-CoV-2} Vaccine at Completion of Blinded Phase},
volume = {385},
year = {2021},
}
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