@article{RN263,
   author = {Elschot, E. P. and Backes, W. H. and Postma, A. A. and van Oostenbrugge, R. J. and Staals, J. and Rouhl, R. P. W. and Jansen, J. F. A.},
   title = {A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity},
   journal = {Invest Radiol},
   note = {Elschot, Elles P
Backes, Walter H
Postma, Alida A
van Oostenbrugge, Robert J
Staals, Julie
Rouhl, Rob P W
Jansen, Jacobus F A
eng
Invest Radiol. 2020 Sep 15. doi: 10.1097/RLI.0000000000000723.},
   abstract = {The blood-brain barrier (BBB) is the interface between the blood and brain tissue, which regulates the maintenance of homeostasis within the brain. Impaired BBB integrity is increasingly associated with various neurological diseases. To gain a better understanding of the underlying processes involved in BBB breakdown, magnetic resonance imaging (MRI) techniques are highly suitable for noninvasive BBB assessment. Commonly used MRI techniques to assess BBB integrity are dynamic contrast-enhanced and dynamic susceptibility contrast MRI, both relying on leakage of gadolinium-based contrast agents. A number of conceptually different methods exist that target other aspects of the BBB. These alternative techniques make use of endogenous markers, such as water and glucose, as contrast media. A comprehensive overview of currently available MRI techniques to assess the BBB condition is provided from a scientific point of view, including potential applications in disease. Improvements that are required to make these techniques clinically more easily applicable will also be discussed.},
   ISSN = {1536-0210 (Electronic)
0020-9996 (Linking)},
   DOI = {10.1097/RLI.0000000000000723},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/32932377},
   year = {2020},
   type = {Journal Article}
}

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A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Elschot"],"firstnames":["E.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Rouhl"],"firstnames":["R.","P.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity","journal":"Invest Radiol","note":"Elschot, Elles P Backes, Walter H Postma, Alida A van Oostenbrugge, Robert J Staals, Julie Rouhl, Rob P W Jansen, Jacobus F A eng Invest Radiol. 2020 Sep 15. doi: 10.1097/RLI.0000000000000723.","abstract":"The blood-brain barrier (BBB) is the interface between the blood and brain tissue, which regulates the maintenance of homeostasis within the brain. Impaired BBB integrity is increasingly associated with various neurological diseases. To gain a better understanding of the underlying processes involved in BBB breakdown, magnetic resonance imaging (MRI) techniques are highly suitable for noninvasive BBB assessment. Commonly used MRI techniques to assess BBB integrity are dynamic contrast-enhanced and dynamic susceptibility contrast MRI, both relying on leakage of gadolinium-based contrast agents. A number of conceptually different methods exist that target other aspects of the BBB. These alternative techniques make use of endogenous markers, such as water and glucose, as contrast media. A comprehensive overview of currently available MRI techniques to assess the BBB condition is provided from a scientific point of view, including potential applications in disease. Improvements that are required to make these techniques clinically more easily applicable will also be discussed.","issn":"1536-0210 (Electronic) 0020-9996 (Linking)","doi":"10.1097/RLI.0000000000000723","url":"https://www.ncbi.nlm.nih.gov/pubmed/32932377","year":"2020","bibtex":"@article{RN263,\n author = {Elschot, E. P. and Backes, W. H. and Postma, A. A. and van Oostenbrugge, R. J. and Staals, J. and Rouhl, R. P. W. and Jansen, J. F. A.},\n title = {A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity},\n journal = {Invest Radiol},\n note = {Elschot, Elles P\nBackes, Walter H\nPostma, Alida A\nvan Oostenbrugge, Robert J\nStaals, Julie\nRouhl, Rob P W\nJansen, Jacobus F A\neng\nInvest Radiol. 2020 Sep 15. doi: 10.1097/RLI.0000000000000723.},\n abstract = {The blood-brain barrier (BBB) is the interface between the blood and brain tissue, which regulates the maintenance of homeostasis within the brain. Impaired BBB integrity is increasingly associated with various neurological diseases. To gain a better understanding of the underlying processes involved in BBB breakdown, magnetic resonance imaging (MRI) techniques are highly suitable for noninvasive BBB assessment. Commonly used MRI techniques to assess BBB integrity are dynamic contrast-enhanced and dynamic susceptibility contrast MRI, both relying on leakage of gadolinium-based contrast agents. A number of conceptually different methods exist that target other aspects of the BBB. These alternative techniques make use of endogenous markers, such as water and glucose, as contrast media. A comprehensive overview of currently available MRI techniques to assess the BBB condition is provided from a scientific point of view, including potential applications in disease. 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