@article{RN351,
   author = {Elschot, E. P. and Backes, W. H. and van den Kerkhof, M. and Postma, A. A. and Kroon, A. A. and Jansen, J. F. A.},
   title = {Cerebral Microvascular Perfusion Assessed in Elderly Adults by Spin-Echo Dynamic Susceptibility Contrast MRI at 7 Tesla},
   journal = {Tomography},
   volume = {10},
   number = {1},
   pages = {181-192},
   note = {Elschot, Elles P
Backes, Walter H
van den Kerkhof, Marieke
Postma, Alida A
Kroon, Abraham A
Jansen, Jacobus F A
eng
446002509/ZONMW_/ZonMw/Netherlands
Switzerland
Tomography. 2024 Jan 18;10(1):181-192. doi: 10.3390/tomography10010014.},
   abstract = {Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated. Higher CBV and CBF values were found in CGM compared to WM, whereby the CGM-to-WM ratios depended on the amount of largest vessels excluded from the analysis. CBF was negatively associated with age in the CGM, while no significant association was found with CBV. Both CBV and CBF were higher in women compared to men in both CGM and WM. The current study verifies the possibility of quantifying cerebral microvascular perfusion with SE-DSC MRI at 7 T.},
   keywords = {7 Tesla
cerebral blood flow
dynamic susceptibility contrast
microvascular perfusion
spin echo
ultra-high field},
   ISSN = {2379-139X (Electronic)
2379-1381 (Linking)},
   DOI = {10.3390/tomography10010014},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/38250960},
   year = {2024},
   type = {Journal Article}
}

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A."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Elschot"],"firstnames":["E.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Kerkhof"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]}],"title":"Cerebral Microvascular Perfusion Assessed in Elderly Adults by Spin-Echo Dynamic Susceptibility Contrast MRI at 7 Tesla","journal":"Tomography","volume":"10","number":"1","pages":"181-192","note":"Elschot, Elles P Backes, Walter H van den Kerkhof, Marieke Postma, Alida A Kroon, Abraham A Jansen, Jacobus F A eng 446002509/ZONMW_/ZonMw/Netherlands Switzerland Tomography. 2024 Jan 18;10(1):181-192. doi: 10.3390/tomography10010014.","abstract":"Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated. Higher CBV and CBF values were found in CGM compared to WM, whereby the CGM-to-WM ratios depended on the amount of largest vessels excluded from the analysis. CBF was negatively associated with age in the CGM, while no significant association was found with CBV. Both CBV and CBF were higher in women compared to men in both CGM and WM. The current study verifies the possibility of quantifying cerebral microvascular perfusion with SE-DSC MRI at 7 T.","keywords":"7 Tesla cerebral blood flow dynamic susceptibility contrast microvascular perfusion spin echo ultra-high field","issn":"2379-139X (Electronic) 2379-1381 (Linking)","doi":"10.3390/tomography10010014","url":"https://www.ncbi.nlm.nih.gov/pubmed/38250960","year":"2024","bibtex":"@article{RN351,\n author = {Elschot, E. P. and Backes, W. H. and van den Kerkhof, M. and Postma, A. A. and Kroon, A. A. and Jansen, J. F. A.},\n title = {Cerebral Microvascular Perfusion Assessed in Elderly Adults by Spin-Echo Dynamic Susceptibility Contrast MRI at 7 Tesla},\n journal = {Tomography},\n volume = {10},\n number = {1},\n pages = {181-192},\n note = {Elschot, Elles P\nBackes, Walter H\nvan den Kerkhof, Marieke\nPostma, Alida A\nKroon, Abraham A\nJansen, Jacobus F A\neng\n446002509/ZONMW_/ZonMw/Netherlands\nSwitzerland\nTomography. 2024 Jan 18;10(1):181-192. doi: 10.3390/tomography10010014.},\n abstract = {Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated. Higher CBV and CBF values were found in CGM compared to WM, whereby the CGM-to-WM ratios depended on the amount of largest vessels excluded from the analysis. CBF was negatively associated with age in the CGM, while no significant association was found with CBV. Both CBV and CBF were higher in women compared to men in both CGM and WM. 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