To BMP or not to BMP during vertebrate limb bud development. Emanuele Pignatti, Rolf Zeller, & Aimée Zuniga Seminars in Cell & Developmental Biology, 2014.
To BMP or not to BMP during vertebrate limb bud development [pdf]Paper  abstract   bibtex   
The analysis of vertebrate limb bud development provides insight of general relevance into the signaling networks that underlie the controlled proliferative expansion of large populations of mesenchymal progenitors, cell fate determination and initiation of differentiation. In particular, extensive genetic analysis of mouse and experimental manipulation of chicken limb bud development has revealed the self-regulatory feedback signaling systems that interlink the main morphoregulatory signaling path-ways including BMPs and their antagonists. It this review, we showcase the key role of BMPs and their antagonists during limb bud development. This review provides an understanding of the key morphoreg-ulatory interactions that underlie the highly dynamic changes in BMP activity and signal transduction as limb bud development progresses from initiation and setting-up the signaling centers to determination and formation of the chondrogenic primordia for the limb skeletal elements.

Downloads: 0