@article{englund_risk_2011,
	title = {Risk factors for medial meniscal pathology on knee {MRI} in older {US} adults: a multicentre prospective cohort study.},
	volume = {70},
	issn = {1468-2060 0003-4967},
	doi = {10.1136/ard.2011.150052},
	abstract = {{OBJECTIVES}: Meniscal pathology in which the aetiology is often unclear is a frequent finding on knee {MRI}. This study investigates potential risk factors for  medial meniscal lesions or extrusion in middle-aged and elderly persons. {METHODS}: Prospective cohort study using population-based subjects from Birmingham, Alabama and Iowa City, Iowa, {USA} (the Multicenter Osteoarthritis Study). 644 men and women aged 50-79 years with or at high risk of knee osteoarthritis (Kellgren and  Lawrence grade 0-2) but with normal medial meniscal status at baseline were studied. Paired baseline and 30-month 1.0 T knee {MRI} were scored for meniscal lesions and extrusion (pathology) and the following systemic, knee-specific and compartment-specific potential risk factors were evaluated: age, sex, body mass index, bony enlargement of finger joints, knee trauma, leg-length inequality and  knee alignment. {RESULTS}: Of 791 knees, 77 (9.7\%) had medial meniscal pathology at 30 months follow-up. 61 of the 77 (81\%) had no report of trauma during follow-up. Including all potential risk factors in the multivariable model, the adjusted {OR}  for medial meniscal pathology was 4.14 (95\% {CI} 2.06 to 8.31) for knee trauma during follow-up, 1.64 (1.00 to 2.70) for five or more bony enlargements of finger joints (vs {\textless}/= 4) and 2.00 (1.18 to 3.40) for varus alignment (vs not varus) at baseline examination. Obesity was a risk factor for the development of  meniscal extrusion, {OR} 3.04 (1.04 to 8.93) but not for meniscal lesions, {OR} 1.15  (0.52 to 2.54). {CONCLUSIONS}: Apart from knee trauma, possible generalised osteoarthritis, expressed as multiple bony enlargements of finger joints, varus alignment and obesity are risk factors for medial meniscal pathology.},
	pages = {1733--1739},
	number = {10},
	journaltitle = {Annals of the rheumatic diseases},
	shortjournal = {Ann Rheum Dis},
	author = {Englund, Martin and Felson, David T. and Guermazi, Ali and Roemer, Frank W. and Wang, Ke and Crema, Michel D. and Lynch, John A. and Sharma, Leena and Segal, Neil A. and Lewis, Cora E. and Nevitt, Michael C.},
	date = {2011-10},
	pmid = {21646417},
	pmcid = {PMC4864962},
	keywords = {*Magnetic Resonance Imaging/methods, Aged, Epidemiologic Methods, Female, Finger Joint/pathology, Humans, Joint Deformities, Acquired/pathology, Knee Injuries/pathology, Male, Menisci, Tibial/injuries/*pathology, Middle Aged, Obesity/complications, Osteoarthritis, Knee/*pathology}
}

{"_id":"tHevxKEh4dwPQXiSm","bibbaseid":"englund-felson-guermazi-roemer-wang-crema-lynch-sharma-etal-riskfactorsformedialmeniscalpathologyonkneemriinolderusadultsamulticentreprospectivecohortstudy","downloads":0,"creationDate":"2017-03-31T11:02:36.822Z","title":"Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study.","author_short":["Englund, M.","Felson, D. T.","Guermazi, A.","Roemer, F. W.","Wang, K.","Crema, M. D.","Lynch, J. A.","Sharma, L.","Segal, N. A.","Lewis, C. E.","Nevitt, M. C."],"year":null,"bibtype":"article","biburl":"http://clinicalepidemiology.se/ClinEpi_LU.bib","bibdata":{"bibtype":"article","type":"article","title":"Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study.","volume":"70","issn":"1468-2060 0003-4967","doi":"10.1136/ard.2011.150052","abstract":"OBJECTIVES: Meniscal pathology in which the aetiology is often unclear is a frequent finding on knee MRI. This study investigates potential risk factors for medial meniscal lesions or extrusion in middle-aged and elderly persons. METHODS: Prospective cohort study using population-based subjects from Birmingham, Alabama and Iowa City, Iowa, USA (the Multicenter Osteoarthritis Study). 644 men and women aged 50-79 years with or at high risk of knee osteoarthritis (Kellgren and Lawrence grade 0-2) but with normal medial meniscal status at baseline were studied. Paired baseline and 30-month 1.0 T knee MRI were scored for meniscal lesions and extrusion (pathology) and the following systemic, knee-specific and compartment-specific potential risk factors were evaluated: age, sex, body mass index, bony enlargement of finger joints, knee trauma, leg-length inequality and knee alignment. RESULTS: Of 791 knees, 77 (9.7%) had medial meniscal pathology at 30 months follow-up. 61 of the 77 (81%) had no report of trauma during follow-up. Including all potential risk factors in the multivariable model, the adjusted OR for medial meniscal pathology was 4.14 (95% CI 2.06 to 8.31) for knee trauma during follow-up, 1.64 (1.00 to 2.70) for five or more bony enlargements of finger joints (vs \\textless/= 4) and 2.00 (1.18 to 3.40) for varus alignment (vs not varus) at baseline examination. Obesity was a risk factor for the development of meniscal extrusion, OR 3.04 (1.04 to 8.93) but not for meniscal lesions, OR 1.15 (0.52 to 2.54). CONCLUSIONS: Apart from knee trauma, possible generalised osteoarthritis, expressed as multiple bony enlargements of finger joints, varus alignment and obesity are risk factors for medial meniscal pathology.","pages":"1733--1739","number":"10","journaltitle":"Annals of the rheumatic diseases","shortjournal":"Ann Rheum Dis","author":[{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Felson"],"firstnames":["David","T."],"suffixes":[]},{"propositions":[],"lastnames":["Guermazi"],"firstnames":["Ali"],"suffixes":[]},{"propositions":[],"lastnames":["Roemer"],"firstnames":["Frank","W."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Ke"],"suffixes":[]},{"propositions":[],"lastnames":["Crema"],"firstnames":["Michel","D."],"suffixes":[]},{"propositions":[],"lastnames":["Lynch"],"firstnames":["John","A."],"suffixes":[]},{"propositions":[],"lastnames":["Sharma"],"firstnames":["Leena"],"suffixes":[]},{"propositions":[],"lastnames":["Segal"],"firstnames":["Neil","A."],"suffixes":[]},{"propositions":[],"lastnames":["Lewis"],"firstnames":["Cora","E."],"suffixes":[]},{"propositions":[],"lastnames":["Nevitt"],"firstnames":["Michael","C."],"suffixes":[]}],"date":"2011-10","pmid":"21646417","pmcid":"PMC4864962","keywords":"*Magnetic Resonance Imaging/methods, Aged, Epidemiologic Methods, Female, Finger Joint/pathology, Humans, Joint Deformities, Acquired/pathology, Knee Injuries/pathology, Male, Menisci, Tibial/injuries/*pathology, Middle Aged, Obesity/complications, Osteoarthritis, Knee/*pathology","bibtex":"@article{englund_risk_2011,\n\ttitle = {Risk factors for medial meniscal pathology on knee {MRI} in older {US} adults: a multicentre prospective cohort study.},\n\tvolume = {70},\n\tissn = {1468-2060 0003-4967},\n\tdoi = {10.1136/ard.2011.150052},\n\tabstract = {{OBJECTIVES}: Meniscal pathology in which the aetiology is often unclear is a frequent finding on knee {MRI}. This study investigates potential risk factors for medial meniscal lesions or extrusion in middle-aged and elderly persons. {METHODS}: Prospective cohort study using population-based subjects from Birmingham, Alabama and Iowa City, Iowa, {USA} (the Multicenter Osteoarthritis Study). 644 men and women aged 50-79 years with or at high risk of knee osteoarthritis (Kellgren and Lawrence grade 0-2) but with normal medial meniscal status at baseline were studied. Paired baseline and 30-month 1.0 T knee {MRI} were scored for meniscal lesions and extrusion (pathology) and the following systemic, knee-specific and compartment-specific potential risk factors were evaluated: age, sex, body mass index, bony enlargement of finger joints, knee trauma, leg-length inequality and knee alignment. {RESULTS}: Of 791 knees, 77 (9.7\\%) had medial meniscal pathology at 30 months follow-up. 61 of the 77 (81\\%) had no report of trauma during follow-up. Including all potential risk factors in the multivariable model, the adjusted {OR} for medial meniscal pathology was 4.14 (95\\% {CI} 2.06 to 8.31) for knee trauma during follow-up, 1.64 (1.00 to 2.70) for five or more bony enlargements of finger joints (vs {\\textless}/= 4) and 2.00 (1.18 to 3.40) for varus alignment (vs not varus) at baseline examination. Obesity was a risk factor for the development of meniscal extrusion, {OR} 3.04 (1.04 to 8.93) but not for meniscal lesions, {OR} 1.15 (0.52 to 2.54). {CONCLUSIONS}: Apart from knee trauma, possible generalised osteoarthritis, expressed as multiple bony enlargements of finger joints, varus alignment and obesity are risk factors for medial meniscal pathology.},\n\tpages = {1733--1739},\n\tnumber = {10},\n\tjournaltitle = {Annals of the rheumatic diseases},\n\tshortjournal = {Ann Rheum Dis},\n\tauthor = {Englund, Martin and Felson, David T. and Guermazi, Ali and Roemer, Frank W. and Wang, Ke and Crema, Michel D. and Lynch, John A. and Sharma, Leena and Segal, Neil A. and Lewis, Cora E. and Nevitt, Michael C.},\n\tdate = {2011-10},\n\tpmid = {21646417},\n\tpmcid = {PMC4864962},\n\tkeywords = {*Magnetic Resonance Imaging/methods, Aged, Epidemiologic Methods, Female, Finger Joint/pathology, Humans, Joint Deformities, Acquired/pathology, Knee Injuries/pathology, Male, Menisci, Tibial/injuries/*pathology, Middle Aged, Obesity/complications, Osteoarthritis, Knee/*pathology}\n}\n\n","author_short":["Englund, M.","Felson, D. T.","Guermazi, A.","Roemer, F. W.","Wang, K.","Crema, M. D.","Lynch, J. A.","Sharma, L.","Segal, N. A.","Lewis, C. E.","Nevitt, M. C."],"key":"englund_risk_2011","id":"englund_risk_2011","bibbaseid":"englund-felson-guermazi-roemer-wang-crema-lynch-sharma-etal-riskfactorsformedialmeniscalpathologyonkneemriinolderusadultsamulticentreprospectivecohortstudy","role":"author","urls":{},"keyword":["*Magnetic Resonance Imaging/methods","Aged","Epidemiologic Methods","Female","Finger Joint/pathology","Humans","Joint Deformities","Acquired/pathology","Knee Injuries/pathology","Male","Menisci","Tibial/injuries/*pathology","Middle Aged","Obesity/complications","Osteoarthritis","Knee/*pathology"],"downloads":0},"search_terms":["risk","factors","medial","meniscal","pathology","knee","mri","older","adults","multicentre","prospective","cohort","study","englund","felson","guermazi","roemer","wang","crema","lynch","sharma","segal","lewis","nevitt"],"keywords":["*magnetic resonance imaging/methods","aged","epidemiologic methods","female","finger joint/pathology","humans","joint deformities","acquired/pathology","knee injuries/pathology","male","menisci","tibial/injuries/*pathology","middle aged","obesity/complications","osteoarthritis","knee/*pathology"],"authorIDs":["58de1314e37c0a4446000026"],"dataSources":["824aokLfuuJkJwfhw"]}