Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons. Erdélyi, L., Ilyin, V., Lozovaya, N., & Vulfius, C. Neuroscience Letters, 117(1-2):99–104, Elsevier, sep, 1990. Paper doi abstract bibtex The effects of intracellular Mg2+ (2-8 mM) upon the transient outward current (the A-current) under normal conditions and under catechol-induced blockage were studied in molluscan neurons by using the voltage-clamp and intracellular dialysis techniques. Identified giant Lymnaea stagnalis L. neurons were investigated at room temperature (20-22°C). When applied intracellularly, Mg2+ caused both time- and dose-dependent shifts of the voltage dependence of the steady-state activation and inactivation of the A-current to more negative membrane potentials. Upon external application, catechol suppressed (5-6 mM) or eliminated (9-10 mM) the A-currents, slowed down the current decay and shifted the activation and inactivation curves to more positive membrane voltages. Intracellular Mg2+ decreased the blocking ability of extracellularly applied catechol, whereas catechol antagonized the Mg2+-induced negative shift of the steady-state activation and inactivation curves of the A-currents. © 1990.
@article{pop00334,
abstract = {The effects of intracellular Mg2+ (2-8 mM) upon the transient outward current (the A-current) under normal conditions and under catechol-induced blockage were studied in molluscan neurons by using the voltage-clamp and intracellular dialysis techniques. Identified giant Lymnaea stagnalis L. neurons were investigated at room temperature (20-22°C). When applied intracellularly, Mg2+ caused both time- and dose-dependent shifts of the voltage dependence of the steady-state activation and inactivation of the A-current to more negative membrane potentials. Upon external application, catechol suppressed (5-6 mM) or eliminated (9-10 mM) the A-currents, slowed down the current decay and shifted the activation and inactivation curves to more positive membrane voltages. Intracellular Mg2+ decreased the blocking ability of extracellularly applied catechol, whereas catechol antagonized the Mg2+-induced negative shift of the steady-state activation and inactivation curves of the A-currents. {\textcopyright} 1990.},
annote = {Query date: 2020-06-29 13:05:30},
author = {Erd{\'{e}}lyi, L. and Ilyin, V.I. and Lozovaya, N.A. and Vulfius, C.A.},
doi = {10.1016/0304-3940(90)90126-T},
issn = {03043940},
journal = {Neuroscience Letters},
keywords = {A-current,Catechol-induced blockage,Intracellular Mg2+,Lymnaea neuron,Voltage clamp},
month = {sep},
number = {1-2},
pages = {99--104},
publisher = {Elsevier},
title = {{Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons}},
url = {https://www.sciencedirect.com/science/article/pii/030439409090126T https://linkinghub.elsevier.com/retrieve/pii/030439409090126T},
volume = {117},
year = {1990}
}
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Upon external application, catechol suppressed (5-6 mM) or eliminated (9-10 mM) the A-currents, slowed down the current decay and shifted the activation and inactivation curves to more positive membrane voltages. 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Identified giant Lymnaea stagnalis L. neurons were investigated at room temperature (20-22°C). When applied intracellularly, Mg2+ caused both time- and dose-dependent shifts of the voltage dependence of the steady-state activation and inactivation of the A-current to more negative membrane potentials. Upon external application, catechol suppressed (5-6 mM) or eliminated (9-10 mM) the A-currents, slowed down the current decay and shifted the activation and inactivation curves to more positive membrane voltages. 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