@article{pop00334,
abstract = {The effects of intracellular Mg2+ (2-8 mM) upon the transient outward current (the A-current) under normal conditions and under catechol-induced blockage were studied in molluscan neurons by using the voltage-clamp and intracellular dialysis techniques. Identified giant Lymnaea stagnalis L. neurons were investigated at room temperature (20-22°C). When applied intracellularly, Mg2+ caused both time- and dose-dependent shifts of the voltage dependence of the steady-state activation and inactivation of the A-current to more negative membrane potentials. Upon external application, catechol suppressed (5-6 mM) or eliminated (9-10 mM) the A-currents, slowed down the current decay and shifted the activation and inactivation curves to more positive membrane voltages. Intracellular Mg2+ decreased the blocking ability of extracellularly applied catechol, whereas catechol antagonized the Mg2+-induced negative shift of the steady-state activation and inactivation curves of the A-currents. {\textcopyright} 1990.},
annote = {Query date: 2020-06-29 13:05:30},
author = {Erd{\'{e}}lyi, L. and Ilyin, V.I. and Lozovaya, N.A. and Vulfius, C.A.},
doi = {10.1016/0304-3940(90)90126-T},
issn = {03043940},
journal = {Neuroscience Letters},
keywords = {A-current,Catechol-induced blockage,Intracellular Mg2+,Lymnaea neuron,Voltage clamp},
month = {sep},
number = {1-2},
pages = {99--104},
publisher = {Elsevier},
title = {{Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons}},
url = {https://www.sciencedirect.com/science/article/pii/030439409090126T https://linkinghub.elsevier.com/retrieve/pii/030439409090126T},
volume = {117},
year = {1990}
}

{"_id":"EQ5dsAobzj7P7zPhv","bibbaseid":"erdlyi-ilyin-lozovaya-vulfius-intracellularmg2modulatestheacurrentanditsblockagebycatecholinisolatedlymnaeaneurons-1990","author_short":["Erdélyi, L.","Ilyin, V.","Lozovaya, N.","Vulfius, C."],"bibdata":{"bibtype":"article","type":"article","abstract":"The effects of intracellular Mg2+ (2-8 mM) upon the transient outward current (the A-current) under normal conditions and under catechol-induced blockage were studied in molluscan neurons by using the voltage-clamp and intracellular dialysis techniques. Identified giant Lymnaea stagnalis L. neurons were investigated at room temperature (20-22°C). When applied intracellularly, Mg2+ caused both time- and dose-dependent shifts of the voltage dependence of the steady-state activation and inactivation of the A-current to more negative membrane potentials. Upon external application, catechol suppressed (5-6 mM) or eliminated (9-10 mM) the A-currents, slowed down the current decay and shifted the activation and inactivation curves to more positive membrane voltages. Intracellular Mg2+ decreased the blocking ability of extracellularly applied catechol, whereas catechol antagonized the Mg2+-induced negative shift of the steady-state activation and inactivation curves of the A-currents. © 1990.","annote":"Query date: 2020-06-29 13:05:30","author":[{"propositions":[],"lastnames":["Erdélyi"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Ilyin"],"firstnames":["V.I."],"suffixes":[]},{"propositions":[],"lastnames":["Lozovaya"],"firstnames":["N.A."],"suffixes":[]},{"propositions":[],"lastnames":["Vulfius"],"firstnames":["C.A."],"suffixes":[]}],"doi":"10.1016/0304-3940(90)90126-T","issn":"03043940","journal":"Neuroscience Letters","keywords":"A-current,Catechol-induced blockage,Intracellular Mg2+,Lymnaea neuron,Voltage clamp","month":"sep","number":"1-2","pages":"99–104","publisher":"Elsevier","title":"Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons","url":"https://www.sciencedirect.com/science/article/pii/030439409090126T https://linkinghub.elsevier.com/retrieve/pii/030439409090126T","volume":"117","year":"1990","bibtex":"@article{pop00334,\nabstract = {The effects of intracellular Mg2+ (2-8 mM) upon the transient outward current (the A-current) under normal conditions and under catechol-induced blockage were studied in molluscan neurons by using the voltage-clamp and intracellular dialysis techniques. Identified giant Lymnaea stagnalis L. neurons were investigated at room temperature (20-22°C). When applied intracellularly, Mg2+ caused both time- and dose-dependent shifts of the voltage dependence of the steady-state activation and inactivation of the A-current to more negative membrane potentials. Upon external application, catechol suppressed (5-6 mM) or eliminated (9-10 mM) the A-currents, slowed down the current decay and shifted the activation and inactivation curves to more positive membrane voltages. Intracellular Mg2+ decreased the blocking ability of extracellularly applied catechol, whereas catechol antagonized the Mg2+-induced negative shift of the steady-state activation and inactivation curves of the A-currents. {\\textcopyright} 1990.},\nannote = {Query date: 2020-06-29 13:05:30},\nauthor = {Erd{\\'{e}}lyi, L. and Ilyin, V.I. and Lozovaya, N.A. and Vulfius, C.A.},\ndoi = {10.1016/0304-3940(90)90126-T},\nissn = {03043940},\njournal = {Neuroscience Letters},\nkeywords = {A-current,Catechol-induced blockage,Intracellular Mg2+,Lymnaea neuron,Voltage clamp},\nmonth = {sep},\nnumber = {1-2},\npages = {99--104},\npublisher = {Elsevier},\ntitle = {{Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons}},\nurl = {https://www.sciencedirect.com/science/article/pii/030439409090126T https://linkinghub.elsevier.com/retrieve/pii/030439409090126T},\nvolume = {117},\nyear = {1990}\n}\n","author_short":["Erdélyi, L.","Ilyin, V.","Lozovaya, N.","Vulfius, C."],"key":"pop00334","id":"pop00334","bibbaseid":"erdlyi-ilyin-lozovaya-vulfius-intracellularmg2modulatestheacurrentanditsblockagebycatecholinisolatedlymnaeaneurons-1990","role":"author","urls":{"Paper":"https://www.sciencedirect.com/science/article/pii/030439409090126T https://linkinghub.elsevier.com/retrieve/pii/030439409090126T"},"keyword":["A-current","Catechol-induced blockage","Intracellular Mg2+","Lymnaea neuron","Voltage clamp"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"http://lymnaea.org/data/lymnaeastagnalis-neuroscience.bib","dataSources":["aGHieW6wJ8vBRjMFD"],"keywords":["a-current","catechol-induced blockage","intracellular mg2+","lymnaea neuron","voltage clamp"],"search_terms":["intracellular","mg2","modulates","current","blockage","catechol","isolated","lymnaea","neurons","erdélyi","ilyin","lozovaya","vulfius"],"title":"Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons","year":1990}