Multiplexing Genetic and Nucleosome Positioning Codes: A Computational Approach. Eslami-Mossallam, B., Schram, R., D., Tompitak, M., van Noort, J., & Schiessel, H. PLoS ONE, 11(6):e0156905, 2016.
Multiplexing Genetic and Nucleosome Positioning Codes: A Computational Approach [pdf]Paper  Multiplexing Genetic and Nucleosome Positioning Codes: A Computational Approach [link]Website  abstract   bibtex   
© 2016 Eslami-Mossallam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Eukaryotic DNA is strongly bent inside fundamental packaging units: the nucleosomes. It is known that their positions are strongly influenced by the mechanical properties of the underlying DNA sequence. Here we discuss the possibility that these mechanical properties and the concomitant nucleosome positions are not just a side product of the given DNA sequence, e.g. that of the genes, but that a mechanical evolution of DNA molecules might have taken place. We first demonstrate the possibility of multiplexing classical and mechanical genetic information using a computational nucleosome model. In a second step we give evidence for genome-wide multiplexing in Saccharomyces cerevisiae and Schizosacharomyces pombe. This suggests that the exact positions of nucleosomes play crucial roles in chromatin function.

Downloads: 0