Transcriptional biomarkers for predicting development of TB: progress and clinical considerations. Esmail, H., Cobelens, F., & Goletti, D. European Respiratory Journal, 55(3):1901957, jan, 2020. ![Transcriptional biomarkers for predicting development of TB: progress and clinical considerations [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Achieving the ambitious targets for global tuberculosis (TB) control, will require an increased emphasis on preventing development of active disease in those with latent TB infection (LTBI) by preventative treatment or vaccination [1]. New shortened regimens of 1–3 months duration potentially allow much wider and more effective use of preventive therapy [2, 3]. A significant barrier is the limited ability to reliably identify those at high risk of disease progression, leading to high numbers needed to treat (NNT) to prevent a case of TB [4]. Hence, there is an interest in developing new diagnostic tests that better predict TB disease to allow more targeted preventive treatment and lower NNT [5]. These are often referred to as tests for incipient TB, stemming from the notion that TB prediction with low NNT most likely reflects detection of an early inflammatory response to multiplying M. tuberculosis (Mtb) [6].
@article{Esmail2020,
abstract = {Achieving the ambitious targets for global tuberculosis (TB) control, will require an increased emphasis on preventing development of active disease in those with latent TB infection (LTBI) by preventative treatment or vaccination [1]. New shortened regimens of 1–3 months duration potentially allow much wider and more effective use of preventive therapy [2, 3]. A significant barrier is the limited ability to reliably identify those at high risk of disease progression, leading to high numbers needed to treat (NNT) to prevent a case of TB [4]. Hence, there is an interest in developing new diagnostic tests that better predict TB disease to allow more targeted preventive treatment and lower NNT [5]. These are often referred to as tests for incipient TB, stemming from the notion that TB prediction with low NNT most likely reflects detection of an early inflammatory response to multiplying M. tuberculosis (Mtb) [6].},
author = {Esmail, Hanif and Cobelens, Frank and Goletti, Delia},
doi = {10.1183/13993003.01957-2019},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Esmail, Cobelens, Goletti - 2020 - Transcriptional biomarkers for predicting development of TB progress and clinical considerations.pdf:pdf},
issn = {0903-1936},
journal = {European Respiratory Journal},
keywords = {OA,Review,fund{\_}not{\_}ack},
mendeley-tags = {OA,Review,fund{\_}not{\_}ack},
month = {jan},
number = {3},
pages = {1901957},
pmid = {31949119},
title = {{Transcriptional biomarkers for predicting development of TB: progress and clinical considerations}},
url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01957-2019},
volume = {55},
year = {2020}
}
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