@incollection{Esmail2021,
abstract = {Tuberculosis (TB) affecting the central nervous system (CNS) accounts for 1{\%} of presentations and can either manifest as a subacute lymphocytic meningitis or with neurological deficit relating to space-occupying tuberculoma. Of all the forms of TB it has the most unfavourable outcome especially when patients present with a reduced conscious level. Due to its paucibacillary nature CNS TB is difficult to diagnose though the recent development of Xpert MTB/RIF Ultra promises a rapid diagnostic with high sensitivity. It is important to ensure a large volume of CSF (8–10 mL) is taken to improve the likelihood of a microbiological diagnosis. For treatment, the CSF penetration of drugs is important to consider, however, the recommended first-line regimen for drug sensitive CNS disease is typically the same as for other forms of TB though for 12 rather than 6 months. Adjunctive therapy with Dexamethasone has been shown to reduce mortality and should be prescribed in a tapering dose along with anti-tuberculous therapy.},
address = {Cham},
author = {Esmail, Hanif and Cooke, Graham S.},
booktitle = {Tuberculosis in Clinical Practice},
doi = {10.1007/978-3-030-75509-6_6},
editor = {Kon, O M},
isbn = {978-3-030-75509-6},
keywords = {book{\_}chap},
mendeley-tags = {book{\_}chap},
month = {oct},
pages = {85--95},
publisher = {Springer, Cham},
title = {{Tuberculosis of the central nervous system}},
url = {https://link.springer.com/chapter/10.1007/978-3-030-75509-6{\_}6},
year = {2021}
}

{"_id":"cdk7tZ7uT842iiYEi","bibbaseid":"esmail-cooke-tuberculosisofthecentralnervoussystem-2021","author_short":["Esmail, H.","Cooke, G. S."],"bibdata":{"bibtype":"incollection","type":"incollection","abstract":"Tuberculosis (TB) affecting the central nervous system (CNS) accounts for 1% of presentations and can either manifest as a subacute lymphocytic meningitis or with neurological deficit relating to space-occupying tuberculoma. Of all the forms of TB it has the most unfavourable outcome especially when patients present with a reduced conscious level. Due to its paucibacillary nature CNS TB is difficult to diagnose though the recent development of Xpert MTB/RIF Ultra promises a rapid diagnostic with high sensitivity. It is important to ensure a large volume of CSF (8–10 mL) is taken to improve the likelihood of a microbiological diagnosis. For treatment, the CSF penetration of drugs is important to consider, however, the recommended first-line regimen for drug sensitive CNS disease is typically the same as for other forms of TB though for 12 rather than 6 months. Adjunctive therapy with Dexamethasone has been shown to reduce mortality and should be prescribed in a tapering dose along with anti-tuberculous therapy.","address":"Cham","author":[{"propositions":[],"lastnames":["Esmail"],"firstnames":["Hanif"],"suffixes":[]},{"propositions":[],"lastnames":["Cooke"],"firstnames":["Graham","S."],"suffixes":[]}],"booktitle":"Tuberculosis in Clinical Practice","doi":"10.1007/978-3-030-75509-6_6","editor":[{"propositions":[],"lastnames":["Kon"],"firstnames":["O","M"],"suffixes":[]}],"isbn":"978-3-030-75509-6","keywords":"book_chap","mendeley-tags":"book_chap","month":"oct","pages":"85–95","publisher":"Springer, Cham","title":"Tuberculosis of the central nervous system","url":"https://link.springer.com/chapter/10.1007/978-3-030-75509-6\\_6","year":"2021","bibtex":"@incollection{Esmail2021,\r\nabstract = {Tuberculosis (TB) affecting the central nervous system (CNS) accounts for 1{\\%} of presentations and can either manifest as a subacute lymphocytic meningitis or with neurological deficit relating to space-occupying tuberculoma. Of all the forms of TB it has the most unfavourable outcome especially when patients present with a reduced conscious level. Due to its paucibacillary nature CNS TB is difficult to diagnose though the recent development of Xpert MTB/RIF Ultra promises a rapid diagnostic with high sensitivity. It is important to ensure a large volume of CSF (8–10 mL) is taken to improve the likelihood of a microbiological diagnosis. For treatment, the CSF penetration of drugs is important to consider, however, the recommended first-line regimen for drug sensitive CNS disease is typically the same as for other forms of TB though for 12 rather than 6 months. Adjunctive therapy with Dexamethasone has been shown to reduce mortality and should be prescribed in a tapering dose along with anti-tuberculous therapy.},\r\naddress = {Cham},\r\nauthor = {Esmail, Hanif and Cooke, Graham S.},\r\nbooktitle = {Tuberculosis in Clinical Practice},\r\ndoi = {10.1007/978-3-030-75509-6_6},\r\neditor = {Kon, O M},\r\nisbn = {978-3-030-75509-6},\r\nkeywords = {book{\\_}chap},\r\nmendeley-tags = {book{\\_}chap},\r\nmonth = {oct},\r\npages = {85--95},\r\npublisher = {Springer, Cham},\r\ntitle = {{Tuberculosis of the central nervous system}},\r\nurl = {https://link.springer.com/chapter/10.1007/978-3-030-75509-6{\\_}6},\r\nyear = {2021}\r\n}\r\n","author_short":["Esmail, H.","Cooke, G. S."],"editor_short":["Kon, O M"],"key":"Esmail2021","id":"Esmail2021","bibbaseid":"esmail-cooke-tuberculosisofthecentralnervoussystem-2021","role":"author","urls":{"Paper":"https://link.springer.com/chapter/10.1007/978-3-030-75509-6\\_6"},"keyword":["book_chap"],"metadata":{"authorlinks":{}}},"bibtype":"incollection","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","dataSources":["Krmt6gt9ktB2s6ARh"],"keywords":["book_chap"],"search_terms":["tuberculosis","central","nervous","system","esmail","cooke"],"title":"Tuberculosis of the central nervous system","year":2021}