@article{Esmail2018b,
abstract = {Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—389,000 deaths per annum are attributable to HIV tuberculosis, 75{\%} of those occurring in Africa. HIV-1 infection increases the risk of tuberculosis by a factor of up to 26 and alters its clinical presentation, complicates diagnosis and treatment, and worsens outcome. Although HIV-1-induced depletion of CD4+ T cells underlies all these effects, more widespread immune deficits also contribute to susceptibility and pathogenesis. These defects present a challenge to understand and ameliorate, but also an opportunity to learn and optimize mechanisms that normally protect people against tuberculosis. The most effective means to prevent and ameliorate tuberculosis in HIV-1-infected people is antiretroviral therapy, but this may be complicated by pathological immune deterioration that in turn requires more effective host-directed anti-inflammatory...},
author = {Esmail, Hanif and Riou, Catherine and {Du Bruyn}, Elsa and Lai, Rachel Pei-Jen and Harley, Yolande X R and Meintjes, Graeme A and Wilkinson, Katalin A and Wilkinson, Robert J},
doi = {10.1146/annurev-immunol-042617-053420},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Esmail et al. - 2018 - The immune response to iMycobacterium tuberculosisi in HIV-1-coinfected persons.pdf:pdf},
issn = {0732-0582},
journal = {Annual Review of Immunology},
keywords = {fund{\_}ack,review},
mendeley-tags = {fund{\_}ack,review},
month = {apr},
number = {1},
pages = {603--638},
pmid = {29490165},
publisher = {Annual Reviews 4139 El Camino Way, PO Box 10139, Palo Alto, California 94303-0139, USA},
title = {{The immune response to \textit{Mycobacterium tuberculosis} in HIV-1-coinfected persons}},
url = {http://www.annualreviews.org/doi/10.1146/annurev-immunol-042617-053420},
volume = {36},
year = {2018}
}

{"_id":"KiuPQfud3oAK9sDHJ","bibbaseid":"esmail-riou-dubruyn-lai-harley-meintjes-wilkinson-wilkinson-theimmuneresponsetoimycobacteriumtuberculosisiinhiv1coinfectedpersons-2018","author_short":["Esmail, H.","Riou, C.","Du Bruyn, E.","Lai, R. P.","Harley, Y. X R","Meintjes, G. A","Wilkinson, K. A","Wilkinson, R. J"],"bibdata":{"bibtype":"article","type":"article","abstract":"Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—389,000 deaths per annum are attributable to HIV tuberculosis, 75% of those occurring in Africa. HIV-1 infection increases the risk of tuberculosis by a factor of up to 26 and alters its clinical presentation, complicates diagnosis and treatment, and worsens outcome. Although HIV-1-induced depletion of CD4+ T cells underlies all these effects, more widespread immune deficits also contribute to susceptibility and pathogenesis. These defects present a challenge to understand and ameliorate, but also an opportunity to learn and optimize mechanisms that normally protect people against tuberculosis. The most effective means to prevent and ameliorate tuberculosis in HIV-1-infected people is antiretroviral therapy, but this may be complicated by pathological immune deterioration that in turn requires more effective host-directed anti-inflammatory...","author":[{"propositions":[],"lastnames":["Esmail"],"firstnames":["Hanif"],"suffixes":[]},{"propositions":[],"lastnames":["Riou"],"firstnames":["Catherine"],"suffixes":[]},{"propositions":[],"lastnames":["Du Bruyn"],"firstnames":["Elsa"],"suffixes":[]},{"propositions":[],"lastnames":["Lai"],"firstnames":["Rachel","Pei-Jen"],"suffixes":[]},{"propositions":[],"lastnames":["Harley"],"firstnames":["Yolande","X","R"],"suffixes":[]},{"propositions":[],"lastnames":["Meintjes"],"firstnames":["Graeme","A"],"suffixes":[]},{"propositions":[],"lastnames":["Wilkinson"],"firstnames":["Katalin","A"],"suffixes":[]},{"propositions":[],"lastnames":["Wilkinson"],"firstnames":["Robert","J"],"suffixes":[]}],"doi":"10.1146/annurev-immunol-042617-053420","file":":C$\\$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Esmail et al. - 2018 - The immune response to iMycobacterium tuberculosisi in HIV-1-coinfected persons.pdf:pdf","issn":"0732-0582","journal":"Annual Review of Immunology","keywords":"fund_ack,review","mendeley-tags":"fund_ack,review","month":"apr","number":"1","pages":"603–638","pmid":"29490165","publisher":"Annual Reviews 4139 El Camino Way, PO Box 10139, Palo Alto, California 94303-0139, USA","title":"The immune response to <i>Mycobacterium tuberculosis</i> in HIV-1-coinfected persons","url":"http://www.annualreviews.org/doi/10.1146/annurev-immunol-042617-053420","volume":"36","year":"2018","bibtex":"@article{Esmail2018b,\r\nabstract = {Globally, about 36.7 million people were living with HIV infection at the end of 2015. The most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—389,000 deaths per annum are attributable to HIV tuberculosis, 75{\\%} of those occurring in Africa. HIV-1 infection increases the risk of tuberculosis by a factor of up to 26 and alters its clinical presentation, complicates diagnosis and treatment, and worsens outcome. Although HIV-1-induced depletion of CD4+ T cells underlies all these effects, more widespread immune deficits also contribute to susceptibility and pathogenesis. These defects present a challenge to understand and ameliorate, but also an opportunity to learn and optimize mechanisms that normally protect people against tuberculosis. The most effective means to prevent and ameliorate tuberculosis in HIV-1-infected people is antiretroviral therapy, but this may be complicated by pathological immune deterioration that in turn requires more effective host-directed anti-inflammatory...},\r\nauthor = {Esmail, Hanif and Riou, Catherine and {Du Bruyn}, Elsa and Lai, Rachel Pei-Jen and Harley, Yolande X R and Meintjes, Graeme A and Wilkinson, Katalin A and Wilkinson, Robert J},\r\ndoi = {10.1146/annurev-immunol-042617-053420},\r\nfile = {:C$\\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Esmail et al. - 2018 - The immune response to iMycobacterium tuberculosisi in HIV-1-coinfected persons.pdf:pdf},\r\nissn = {0732-0582},\r\njournal = {Annual Review of Immunology},\r\nkeywords = {fund{\\_}ack,review},\r\nmendeley-tags = {fund{\\_}ack,review},\r\nmonth = {apr},\r\nnumber = {1},\r\npages = {603--638},\r\npmid = {29490165},\r\npublisher = {Annual Reviews 4139 El Camino Way, PO Box 10139, Palo Alto, California 94303-0139, USA},\r\ntitle = {{The immune response to \\textit{Mycobacterium tuberculosis} in HIV-1-coinfected persons}},\r\nurl = {http://www.annualreviews.org/doi/10.1146/annurev-immunol-042617-053420},\r\nvolume = {36},\r\nyear = {2018}\r\n}\r\n","author_short":["Esmail, H.","Riou, C.","Du Bruyn, E.","Lai, R. P.","Harley, Y. X R","Meintjes, G. A","Wilkinson, K. A","Wilkinson, R. J"],"key":"Esmail2018b","id":"Esmail2018b","bibbaseid":"esmail-riou-dubruyn-lai-harley-meintjes-wilkinson-wilkinson-theimmuneresponsetoimycobacteriumtuberculosisiinhiv1coinfectedpersons-2018","role":"author","urls":{"Paper":"http://www.annualreviews.org/doi/10.1146/annurev-immunol-042617-053420"},"keyword":["fund_ack","review"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","dataSources":["Krmt6gt9ktB2s6ARh"],"keywords":["fund_ack","review"],"search_terms":["immune","response","mycobacterium","tuberculosis","hiv","coinfected","persons","esmail","riou","du bruyn","lai","harley","meintjes","wilkinson","wilkinson"],"title":"The immune response to <i>Mycobacterium tuberculosis</i> in HIV-1-coinfected persons","year":2018}