@article{
 title = {Reference ranges for the concentrations of total and complexed plasma prostate-specific antigen and their ratio in patients with benign prostate hyperplasia},
 type = {article},
 year = {1997},
 identifiers = {[object Object]},
 pages = {268-272},
 volume = {32},
 id = {193d5a85-1d01-3f87-9d49-f02116a3357f},
 created = {2015-09-28T19:28:31.000Z},
 file_attached = {false},
 profile_id = {73d9481d-940a-340e-9e2b-9d5b2e5aeae3},
 last_modified = {2016-01-12T08:44:24.000Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {ISI:A1997YB91300002},
 source_type = {article},
 abstract = {Objective: To establish the normal distribution and reference ranges of
complexed and total prostate-specific antigen (PSA) and the
complexed-to-to-tal PSA ratio according to the age of the patients, so
that PSA can be used to distinguish between prostate cancer and benign
prostate hyperplasia (BPH). Material and Methods: Using specific ELISAs,
total PSA and PSA complexed to alpha(1)-antichymotrypsin (complexed PSA)
were determined in 237 BPH patients, 160 with histologically confirmed
BPH and 77 in whom prostate cancer was excluded by digital rectal
examination, transrectal ultrasound and total PSA measurement, Results:
Both total and complexed PSA correlated with patient age (r = 0.424 and
r = 0.379, p < 0.0001, respectively). However, no correlation was found
between the complexed-to-total PSA ratio and age (r = 0.026, p > 0.2).
The mean complexed-ta-total PSA ratio for the 237 BPH patients was 0.69
+/- 0.11, and only 23 had a ratio >0.8, Conclusions: These results show
that the cut-off point of 0.8 established for the complexed-to-total PSA
ratio is the same for men of all ages, and that the use of this ratio
may avoid many negative prostate biopsies, confirming that
PSA:alpha(1)ACT is a potential marker for differential diagnosis of
prostate carcinoma and BPH.},
 bibtype = {article},
 author = {España, F. and Martinez, M and Royo, M. and Vera, C D and Estellés, A. and Aznar, J. and Jiménez-Cruz, J.F.},
 journal = {EUROPEAN UROLOGY},
 number = {3}
}

{"_id":"6m3aB8jrgcXx2wtoh","bibbaseid":"espaa-martinez-royo-vera-estells-aznar-jimnezcruz-referencerangesfortheconcentrationsoftotalandcomplexedplasmaprostatespecificantigenandtheirratioinpatientswithbenignprostatehyperplasia-1997","downloads":0,"creationDate":"2016-04-05T07:21:42.895Z","title":"Reference ranges for the concentrations of total and complexed plasma prostate-specific antigen and their ratio in patients with benign prostate hyperplasia","author_short":["España, F.","Martinez, M.","Royo, M.","Vera, C., D.","Estellés, A.","Aznar, J.","Jiménez-Cruz, J."],"year":1997,"bibtype":"article","biburl":null,"bibdata":{"title":"Reference ranges for the concentrations of total and complexed plasma prostate-specific antigen and their ratio in patients with benign prostate hyperplasia","type":"article","year":"1997","identifiers":"[object Object]","pages":"268-272","volume":"32","id":"193d5a85-1d01-3f87-9d49-f02116a3357f","created":"2015-09-28T19:28:31.000Z","file_attached":false,"profile_id":"73d9481d-940a-340e-9e2b-9d5b2e5aeae3","last_modified":"2016-01-12T08:44:24.000Z","read":"true","starred":false,"authored":"true","confirmed":"true","hidden":false,"citation_key":"ISI:A1997YB91300002","source_type":"article","abstract":"Objective: To establish the normal distribution and reference ranges of\ncomplexed and total prostate-specific antigen (PSA) and the\ncomplexed-to-to-tal PSA ratio according to the age of the patients, so\nthat PSA can be used to distinguish between prostate cancer and benign\nprostate hyperplasia (BPH). Material and Methods: Using specific ELISAs,\ntotal PSA and PSA complexed to alpha(1)-antichymotrypsin (complexed PSA)\nwere determined in 237 BPH patients, 160 with histologically confirmed\nBPH and 77 in whom prostate cancer was excluded by digital rectal\nexamination, transrectal ultrasound and total PSA measurement, Results:\nBoth total and complexed PSA correlated with patient age (r = 0.424 and\nr = 0.379, p < 0.0001, respectively). However, no correlation was found\nbetween the complexed-to-total PSA ratio and age (r = 0.026, p > 0.2).\nThe mean complexed-ta-total PSA ratio for the 237 BPH patients was 0.69\n+/- 0.11, and only 23 had a ratio >0.8, Conclusions: These results show\nthat the cut-off point of 0.8 established for the complexed-to-total PSA\nratio is the same for men of all ages, and that the use of this ratio\nmay avoid many negative prostate biopsies, confirming that\nPSA:alpha(1)ACT is a potential marker for differential diagnosis of\nprostate carcinoma and BPH.","bibtype":"article","author":"España, F. and Martinez, M and Royo, M. and Vera, C D and Estellés, A. and Aznar, J. and Jiménez-Cruz, J.F.","journal":"EUROPEAN UROLOGY","number":"3","bibtex":"@article{\n title = {Reference ranges for the concentrations of total and complexed plasma prostate-specific antigen and their ratio in patients with benign prostate hyperplasia},\n type = {article},\n year = {1997},\n identifiers = {[object Object]},\n pages = {268-272},\n volume = {32},\n id = {193d5a85-1d01-3f87-9d49-f02116a3357f},\n created = {2015-09-28T19:28:31.000Z},\n file_attached = {false},\n profile_id = {73d9481d-940a-340e-9e2b-9d5b2e5aeae3},\n last_modified = {2016-01-12T08:44:24.000Z},\n read = {true},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n citation_key = {ISI:A1997YB91300002},\n source_type = {article},\n abstract = {Objective: To establish the normal distribution and reference ranges of\ncomplexed and total prostate-specific antigen (PSA) and the\ncomplexed-to-to-tal PSA ratio according to the age of the patients, so\nthat PSA can be used to distinguish between prostate cancer and benign\nprostate hyperplasia (BPH). Material and Methods: Using specific ELISAs,\ntotal PSA and PSA complexed to alpha(1)-antichymotrypsin (complexed PSA)\nwere determined in 237 BPH patients, 160 with histologically confirmed\nBPH and 77 in whom prostate cancer was excluded by digital rectal\nexamination, transrectal ultrasound and total PSA measurement, Results:\nBoth total and complexed PSA correlated with patient age (r = 0.424 and\nr = 0.379, p < 0.0001, respectively). However, no correlation was found\nbetween the complexed-to-total PSA ratio and age (r = 0.026, p > 0.2).\nThe mean complexed-ta-total PSA ratio for the 237 BPH patients was 0.69\n+/- 0.11, and only 23 had a ratio >0.8, Conclusions: These results show\nthat the cut-off point of 0.8 established for the complexed-to-total PSA\nratio is the same for men of all ages, and that the use of this ratio\nmay avoid many negative prostate biopsies, confirming that\nPSA:alpha(1)ACT is a potential marker for differential diagnosis of\nprostate carcinoma and BPH.},\n bibtype = {article},\n author = {España, F. and Martinez, M and Royo, M. and Vera, C D and Estellés, A. and Aznar, J. and Jiménez-Cruz, J.F.},\n journal = {EUROPEAN UROLOGY},\n number = {3}\n}","author_short":["España, F.","Martinez, M.","Royo, M.","Vera, C., D.","Estellés, A.","Aznar, J.","Jiménez-Cruz, J."],"bibbaseid":"espaa-martinez-royo-vera-estells-aznar-jimnezcruz-referencerangesfortheconcentrationsoftotalandcomplexedplasmaprostatespecificantigenandtheirratioinpatientswithbenignprostatehyperplasia-1997","role":"author","urls":{},"downloads":0},"search_terms":["reference","ranges","concentrations","total","complexed","plasma","prostate","specific","antigen","ratio","patients","benign","prostate","hyperplasia","españa","martinez","royo","vera","estellés","aznar","jiménez-cruz"],"keywords":[],"authorIDs":[]}