@ARTICLE{Eze2021-aw,
  title    = "Single-cell atlas of early human brain development highlights
              heterogeneity of human neuroepithelial cells and early radial
              glia",
  author   = "Eze, Ugomma C and Bhaduri, Aparna and Haeussler, Maximilian and
              Nowakowski, Tomasz J and Kriegstein, Arnold R",
  abstract = "The human cortex comprises diverse cell types that emerge from an
              initially uniform neuroepithelium that gives rise to radial glia,
              the neural stem cells of the cortex. To characterize the earliest
              stages of human brain development, we performed single-cell
              RNA-sequencing across regions of the developing human brain,
              including the telencephalon, diencephalon, midbrain, hindbrain
              and cerebellum. We identify nine progenitor populations
              physically proximal to the telencephalon, suggesting more
              heterogeneity than previously described, including a highly
              prevalent mesenchymal-like population that disappears once
              neurogenesis begins. Comparison of human and mouse progenitor
              populations at corresponding stages identifies two progenitor
              clusters that are enriched in the early stages of human cortical
              development. We also find that organoid systems display low
              fidelity to neuroepithelial and early radial glia cell types, but
              improve as neurogenesis progresses. Overall, we provide a
              comprehensive molecular and spatial atlas of early stages of
              human brain and cortical development.",
  journal  = "Nat Neurosci",
  volume   =  24,
  number   =  4,
  pages    = "584--594",
  month    =  mar,
  year     =  2021,
  language = "en"
}

{"_id":"rebvneubDBNgZf2ix","bibbaseid":"eze-bhaduri-haeussler-nowakowski-kriegstein-singlecellatlasofearlyhumanbraindevelopmenthighlightsheterogeneityofhumanneuroepithelialcellsandearlyradialglia-2021","author_short":["Eze, U. C","Bhaduri, A.","Haeussler, M.","Nowakowski, T. J","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia","author":[{"propositions":[],"lastnames":["Eze"],"firstnames":["Ugomma","C"],"suffixes":[]},{"propositions":[],"lastnames":["Bhaduri"],"firstnames":["Aparna"],"suffixes":[]},{"propositions":[],"lastnames":["Haeussler"],"firstnames":["Maximilian"],"suffixes":[]},{"propositions":[],"lastnames":["Nowakowski"],"firstnames":["Tomasz","J"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the developing human brain, including the telencephalon, diencephalon, midbrain, hindbrain and cerebellum. We identify nine progenitor populations physically proximal to the telencephalon, suggesting more heterogeneity than previously described, including a highly prevalent mesenchymal-like population that disappears once neurogenesis begins. Comparison of human and mouse progenitor populations at corresponding stages identifies two progenitor clusters that are enriched in the early stages of human cortical development. We also find that organoid systems display low fidelity to neuroepithelial and early radial glia cell types, but improve as neurogenesis progresses. Overall, we provide a comprehensive molecular and spatial atlas of early stages of human brain and cortical development.","journal":"Nat Neurosci","volume":"24","number":"4","pages":"584–594","month":"March","year":"2021","language":"en","bibtex":"@ARTICLE{Eze2021-aw,\n title = \"Single-cell atlas of early human brain development highlights\n heterogeneity of human neuroepithelial cells and early radial\n glia\",\n author = \"Eze, Ugomma C and Bhaduri, Aparna and Haeussler, Maximilian and\n Nowakowski, Tomasz J and Kriegstein, Arnold R\",\n abstract = \"The human cortex comprises diverse cell types that emerge from an\n initially uniform neuroepithelium that gives rise to radial glia,\n the neural stem cells of the cortex. To characterize the earliest\n stages of human brain development, we performed single-cell\n RNA-sequencing across regions of the developing human brain,\n including the telencephalon, diencephalon, midbrain, hindbrain\n and cerebellum. We identify nine progenitor populations\n physically proximal to the telencephalon, suggesting more\n heterogeneity than previously described, including a highly\n prevalent mesenchymal-like population that disappears once\n neurogenesis begins. Comparison of human and mouse progenitor\n populations at corresponding stages identifies two progenitor\n clusters that are enriched in the early stages of human cortical\n development. We also find that organoid systems display low\n fidelity to neuroepithelial and early radial glia cell types, but\n improve as neurogenesis progresses. Overall, we provide a\n comprehensive molecular and spatial atlas of early stages of\n human brain and cortical development.\",\n journal = \"Nat Neurosci\",\n volume = 24,\n number = 4,\n pages = \"584--594\",\n month = mar,\n year = 2021,\n language = \"en\"\n}\n\n","author_short":["Eze, U. C","Bhaduri, A.","Haeussler, M.","Nowakowski, T. J","Kriegstein, A. R"],"key":"Eze2021-aw","id":"Eze2021-aw","bibbaseid":"eze-bhaduri-haeussler-nowakowski-kriegstein-singlecellatlasofearlyhumanbraindevelopmenthighlightsheterogeneityofhumanneuroepithelialcellsandearlyradialglia-2021","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["single","cell","atlas","early","human","brain","development","highlights","heterogeneity","human","neuroepithelial","cells","early","radial","glia","eze","bhaduri","haeussler","nowakowski","kriegstein"],"title":"Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia","year":2021}