Prevalence of autoantibodies to cyclic citrullinated peptide in patients with rheumatic diseases other than rheumatoid arthritis: a French multicenter study. Fabien, N., Olsson, N. O., Goetz, J., Johanet, C., Escande, A., Bardin, N., Sanmarco, M., Andre, C., Chevailler, A., Humbel, R. L., Chretien, P., Monier, J. C., Fortenfant, F., Oksman, F., Taillefer, M. F., & Sibilia, J. Clin Rev Allergy Immunol, 34(1):40–4, February, 2008.
abstract   bibtex   
Our objective was to evaluate the prevalence of autoantibodies to cyclic citrullinated peptides (anti-CCP aAbs) in a cohort of patients with a variety of inflammatory or non-inflammatory rheumatic diseases other than rheumatoid arthritis (RA). Six hundred and nine serum samples were tested for anti-CCP aAbs and for rheumatoid factor (RF) using enzyme-linked immunosorbent assays and immunonephelometry. The prevalence of anti-CCP aAbs and RF reached 10% and 25%, respectively, using the positive cutoff value suggested by the manufacturers. Using a higher cutoff value (50 U/ml) for both aAbs, the prevalence was lower with 6% and 16%, respectively. The specificity of both markers for RA thus reached 94% and 84%, respectively. Anti-CCP aAbs were found to be elevated in inflammatory and also in non-inflammatory rheumatic diseases in the same proportion. Clinical data obtained for 36 positive patients showed that 17% developed RA within 5 years. In conclusion, anti-CCP aAbs are clearly more specific than RF for RA. Follow-up of anti-CCP aAbs-positive patients with inflammatory or non-inflammatory rheumatic diseases other than RA could be important considering the predictive value of these aAbs for the development of RA.
@article{fabien_prevalence_2008,
	title = {Prevalence of autoantibodies to cyclic citrullinated peptide in patients with rheumatic diseases other than rheumatoid arthritis: a {French} multicenter study},
	volume = {34},
	issn = {1559-0267 (ELECTRONIC); 1080-0549 (LINKING)},
	shorttitle = {Prevalence of autoantibodies to cyclic citrullinated peptide in patients with rheumatic diseases other than rheumatoid arthritis: a {French} multicenter study},
	abstract = {Our objective was to evaluate the prevalence of autoantibodies to cyclic citrullinated peptides (anti-CCP aAbs) in a cohort of patients with a variety of inflammatory or non-inflammatory rheumatic diseases other than rheumatoid arthritis (RA). Six hundred and nine serum samples were tested for anti-CCP aAbs and for rheumatoid factor (RF) using enzyme-linked immunosorbent assays and immunonephelometry. The prevalence of anti-CCP aAbs and RF reached 10\% and 25\%, respectively, using the positive cutoff value suggested by the manufacturers. Using a higher cutoff value (50 U/ml) for both aAbs, the prevalence was lower with 6\% and 16\%, respectively. The specificity of both markers for RA thus reached 94\% and 84\%, respectively. Anti-CCP aAbs were found to be elevated in inflammatory and also in non-inflammatory rheumatic diseases in the same proportion. Clinical data obtained for 36 positive patients showed that 17\% developed RA within 5 years. In conclusion, anti-CCP aAbs are clearly more specific than RF for RA. Follow-up of anti-CCP aAbs-positive patients with inflammatory or non-inflammatory rheumatic diseases other than RA could be important considering the predictive value of these aAbs for the development of RA.},
	number = {1},
	journal = {Clin Rev Allergy Immunol},
	author = {Fabien, N. and Olsson, N. O. and Goetz, J. and Johanet, C. and Escande, A. and Bardin, N. and Sanmarco, M. and Andre, C. and Chevailler, A. and Humbel, R. L. and Chretien, P. and Monier, J. C. and Fortenfant, F. and Oksman, F. and Taillefer, M. F. and Sibilia, J.},
	month = feb,
	year = {2008},
	keywords = {Aged Arthritis, Cyclic/ immunology Predictive Value of Tests Prevalence Rheumatic Diseases/diagnosis/epidemiology/immunology Rheumatoid Factor/blood Sensitivity and Specificity, Rheumatoid/diagnosis/epidemiology/immunology Autoantibodies/ blood Autoimmune Diseases/diagnosis/epidemiology/immunology Enzyme-Linked Immunosorbent Assay Female France/epidemiology Humans Male Middle Aged Peptides},
	pages = {40--4}
}
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