Self-declared stock ownership and association with positive trial outcome in randomized controlled trials with binary outcomes published in general medical journals: a cross-sectional study. Falk Delgado, A. & Falk Delgado, A. Trials, 18:1–6, July, 2017.
Self-declared stock ownership and association with positive trial outcome in randomized controlled trials with binary outcomes published in general medical journals: a cross-sectional study [link]Paper  doi  abstract   bibtex   
\textlessbold\textgreaterBackground: \textless/bold\textgreaterDescribe the prevalence and types of conflicts of interest (COI) in published randomized controlled trials (RCTs) in general medical journals with a binary primary outcome and assess the association between conflicts of interest and favorable outcome.\textlessbold\textgreaterMethods: \textless/bold\textgreaterParallel-group RCTs with a binary primary outcome published in three general medical journals during 2013-2015 were identified. COI type, funding source, and outcome were extracted. Binomial logistic regression model was performed to assess association between COI and funding source with outcome.\textlessbold\textgreaterResults: \textless/bold\textgreaterA total of 509 consecutive parallel-group RCTs were included in the study. COI was reported in 74% in mixed funded RCTs and in 99% in for-profit funded RCTs. Stock ownership was reported in none of the non-profit RCTs, in 7% of mixed funded RCTs, and in 50% of for-profit funded RCTs. Mixed-funded RCTs had employees from the funding company in 11% and for-profit RCTs in 76%. Multivariable logistic regression revealed that stock ownership in the funding company among any of the authors was associated with a favorable outcome (odds ratio = 3.53; 95% confidence interval = 1.59-7.86; p \textless 0.01).\textlessbold\textgreaterConclusion: \textless/bold\textgreaterCOI in for-profit funded RCTs is extensive, because the factors related to COI are not fully independent, a multivariable analysis should be cautiously interpreted. However, after multivariable adjustment only stock ownership from the funding company among authors is associated with a favorable outcome.
@article{falk_delgado_self-declared_2017,
	title = {Self-declared stock ownership and association with positive trial outcome in randomized controlled trials with binary outcomes published in general medical journals: a cross-sectional study},
	volume = {18},
	issn = {17456215},
	shorttitle = {Self-declared stock ownership and association with positive trial outcome in randomized controlled trials with binary outcomes published in general medical journals},
	url = {http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=124337574&site=ehost-live},
	doi = {10.1186/s13063-017-2108-z},
	abstract = {{\textless}bold{\textgreater}Background: {\textless}/bold{\textgreater}Describe the prevalence and types of conflicts of interest (COI) in published randomized controlled trials (RCTs) in general medical journals with a binary primary outcome and assess the association between conflicts of interest and favorable outcome.{\textless}bold{\textgreater}Methods: {\textless}/bold{\textgreater}Parallel-group RCTs with a binary primary outcome published in three general medical journals during 2013-2015 were identified. COI type, funding source, and outcome were extracted. Binomial logistic regression model was performed to assess association between COI and funding source with outcome.{\textless}bold{\textgreater}Results: {\textless}/bold{\textgreater}A total of 509 consecutive parallel-group RCTs were included in the study. COI was reported in 74\% in mixed funded RCTs and in 99\% in for-profit funded RCTs. Stock ownership was reported in none of the non-profit RCTs, in 7\% of mixed funded RCTs, and in 50\% of for-profit funded RCTs. Mixed-funded RCTs had employees from the funding company in 11\% and for-profit RCTs in 76\%. Multivariable logistic regression revealed that stock ownership in the funding company among any of the authors was associated with a favorable outcome (odds ratio = 3.53; 95\% confidence interval = 1.59-7.86; p {\textless} 0.01).{\textless}bold{\textgreater}Conclusion: {\textless}/bold{\textgreater}COI in for-profit funded RCTs is extensive, because the factors related to COI are not fully independent, a multivariable analysis should be cautiously interpreted. However, after multivariable adjustment only stock ownership from the funding company among authors is associated with a favorable outcome.},
	urldate = {2019-05-14},
	journal = {Trials},
	author = {Falk Delgado, Alberto and Falk Delgado, Anna},
	month = jul,
	year = {2017},
	keywords = {7 Ignorance and funding bias, AUTHORSHIP, Biais de financement, CLINICAL trials, CONFLICT of interests, CROSS-sectional method, Conflict of interest, ECONOMIC aspects, ENDOWMENT of research, EXPERIMENTAL design, Employment, HEALTH care industry, Industry funding, LOGISTIC regression analysis, MEDICAL journalism, MULTIVARIATE analysis, NEWSLETTERS, ODDS ratio, PRIVATE sector, QUESTIONNAIRES, RANDOMIZED controlled trials, RCTs, RESEARCH personnel, Randomized controlled trials, SELF-disclosure, STOCK ownership, Stock ownership, TREATMENT effectiveness},
	pages = {1--6},
}

Downloads: 0