@ARTICLE{Fandel2016-ay,
  title    = "Transplanted Human Stem {Cell-Derived} Interneuron Precursors
              Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain
              after Spinal Cord Injury",
  author   = "Fandel, Thomas M and Trivedi, Alpa and Nicholas, Cory R and
              Zhang, Haoqian and Chen, Jiadong and Martinez, Aida F and
              Noble-Haeusslein, Linda J and Kriegstein, Arnold R",
  abstract = "Neuropathic pain and bladder dysfunction represent significant
              quality-of-life issues for many spinal cord injury patients. Loss
              of GABAergic tone in the injured spinal cord may contribute to
              the emergence of these symptoms. Previous studies have shown that
              transplantation of rodent inhibitory interneuron precursors from
              the medial ganglionic eminence (MGE) enhances GABAergic signaling
              in the brain and spinal cord. Here we look at whether
              transplanted MGE-like cells derived from human embryonic stem
              cells (hESC-MGEs) can mitigate the pathological effects of spinal
              cord injury. We find that 6 months after transplantation into
              injured mouse spinal cords, hESC-MGEs differentiate into
              GABAergic neuron subtypes and receive synaptic inputs, suggesting
              functional integration into host spinal cord. Moreover, the
              transplanted animals show improved bladder function and
              mitigation of pain-related symptoms. Our results therefore
              suggest that this approach may be a valuable strategy for
              ameliorating the adverse effects of spinal cord injury.",
  journal  = "Cell Stem Cell",
  volume   =  19,
  number   =  4,
  pages    = "544--557",
  month    =  sep,
  year     =  2016,
  address  = "United States",
  keywords = "GABA; MGE; allodynia; bladder; conscious cystometry;
              electrophysiology; human pluripotent stem cells; hyperalgesia;
              interneuron; spinal cord injury",
  language = "en"
}

{"_id":"4kG9s5ShDiuQsb9X9","bibbaseid":"fandel-trivedi-nicholas-zhang-chen-martinez-noblehaeusslein-kriegstein-transplantedhumanstemcellderivedinterneuronprecursorsmitigatemousebladderdysfunctionandcentralneuropathicpainafterspinalcordinjury-2016","author_short":["Fandel, T. M","Trivedi, A.","Nicholas, C. R","Zhang, H.","Chen, J.","Martinez, A. F","Noble-Haeusslein, L. J","Kriegstein, A. R"],"bibdata":{"bibtype":"article","type":"article","title":"Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury","author":[{"propositions":[],"lastnames":["Fandel"],"firstnames":["Thomas","M"],"suffixes":[]},{"propositions":[],"lastnames":["Trivedi"],"firstnames":["Alpa"],"suffixes":[]},{"propositions":[],"lastnames":["Nicholas"],"firstnames":["Cory","R"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Haoqian"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Jiadong"],"suffixes":[]},{"propositions":[],"lastnames":["Martinez"],"firstnames":["Aida","F"],"suffixes":[]},{"propositions":[],"lastnames":["Noble-Haeusslein"],"firstnames":["Linda","J"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]}],"abstract":"Neuropathic pain and bladder dysfunction represent significant quality-of-life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to the emergence of these symptoms. Previous studies have shown that transplantation of rodent inhibitory interneuron precursors from the medial ganglionic eminence (MGE) enhances GABAergic signaling in the brain and spinal cord. Here we look at whether transplanted MGE-like cells derived from human embryonic stem cells (hESC-MGEs) can mitigate the pathological effects of spinal cord injury. We find that 6 months after transplantation into injured mouse spinal cords, hESC-MGEs differentiate into GABAergic neuron subtypes and receive synaptic inputs, suggesting functional integration into host spinal cord. Moreover, the transplanted animals show improved bladder function and mitigation of pain-related symptoms. Our results therefore suggest that this approach may be a valuable strategy for ameliorating the adverse effects of spinal cord injury.","journal":"Cell Stem Cell","volume":"19","number":"4","pages":"544–557","month":"September","year":"2016","address":"United States","keywords":"GABA; MGE; allodynia; bladder; conscious cystometry; electrophysiology; human pluripotent stem cells; hyperalgesia; interneuron; spinal cord injury","language":"en","bibtex":"@ARTICLE{Fandel2016-ay,\n title = \"Transplanted Human Stem {Cell-Derived} Interneuron Precursors\n Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain\n after Spinal Cord Injury\",\n author = \"Fandel, Thomas M and Trivedi, Alpa and Nicholas, Cory R and\n Zhang, Haoqian and Chen, Jiadong and Martinez, Aida F and\n Noble-Haeusslein, Linda J and Kriegstein, Arnold R\",\n abstract = \"Neuropathic pain and bladder dysfunction represent significant\n quality-of-life issues for many spinal cord injury patients. Loss\n of GABAergic tone in the injured spinal cord may contribute to\n the emergence of these symptoms. Previous studies have shown that\n transplantation of rodent inhibitory interneuron precursors from\n the medial ganglionic eminence (MGE) enhances GABAergic signaling\n in the brain and spinal cord. Here we look at whether\n transplanted MGE-like cells derived from human embryonic stem\n cells (hESC-MGEs) can mitigate the pathological effects of spinal\n cord injury. We find that 6 months after transplantation into\n injured mouse spinal cords, hESC-MGEs differentiate into\n GABAergic neuron subtypes and receive synaptic inputs, suggesting\n functional integration into host spinal cord. Moreover, the\n transplanted animals show improved bladder function and\n mitigation of pain-related symptoms. Our results therefore\n suggest that this approach may be a valuable strategy for\n ameliorating the adverse effects of spinal cord injury.\",\n journal = \"Cell Stem Cell\",\n volume = 19,\n number = 4,\n pages = \"544--557\",\n month = sep,\n year = 2016,\n address = \"United States\",\n keywords = \"GABA; MGE; allodynia; bladder; conscious cystometry;\n electrophysiology; human pluripotent stem cells; hyperalgesia;\n interneuron; spinal cord injury\",\n language = \"en\"\n}\n\n","author_short":["Fandel, T. M","Trivedi, A.","Nicholas, C. R","Zhang, H.","Chen, J.","Martinez, A. F","Noble-Haeusslein, L. J","Kriegstein, A. R"],"key":"Fandel2016-ay","id":"Fandel2016-ay","bibbaseid":"fandel-trivedi-nicholas-zhang-chen-martinez-noblehaeusslein-kriegstein-transplantedhumanstemcellderivedinterneuronprecursorsmitigatemousebladderdysfunctionandcentralneuropathicpainafterspinalcordinjury-2016","role":"author","urls":{},"keyword":["GABA; MGE; allodynia; bladder; conscious cystometry; electrophysiology; human pluripotent stem cells; hyperalgesia; interneuron; spinal cord injury"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":["gaba; mge; allodynia; bladder; conscious cystometry; electrophysiology; human pluripotent stem cells; hyperalgesia; interneuron; spinal cord injury"],"search_terms":["transplanted","human","stem","cell","derived","interneuron","precursors","mitigate","mouse","bladder","dysfunction","central","neuropathic","pain","spinal","cord","injury","fandel","trivedi","nicholas","zhang","chen","martinez","noble-haeusslein","kriegstein"],"title":"Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury","year":2016}