@misc{fan_m.-c._early_2016,
	title = {Early {Enteral} {Combined} with {Parenteral} {Nutrition} {Treatment} for {Severe} {Traumatic} {Brain} {Injury}: {Effects} on {Immune} {Function}, {Nutritional} {Status} and {Outcomes}},
	url = {http://www.elsevier.com/wps/find/journaldescription.cws_home/722893/description#description},
	abstract = {Objective To compare the conjoint effect of enteral nutrition (EN) and parenteral nutrition (PN) with single EN or PN on immune function, nutritional status, complications and clinical outcomes of patients with severe traumatic brain injury (STBI). Methods A prospective randomized control trial was carried out from January 2009 to May 2012 in Neurological Intensive Care Unit (NICU). Patients of STBI who met the enrolment criteria (Glasgow Coma Scale score 6{\textasciitilde}8; Nutritional Risk Screening {\textgreater} 3) were randomly divided into 3 groups and were administrated EN, PN or EN + PN treatments respectively. The indexes of nutritional status, immune function, complications and clinical outcomes were examined and compared statistically. Results There were 120 patients enrolled in the study, with 40 pationts in each group. In EN+PN group, T lymthocyte subsets CD3+\%, CD4+\%, ratio of CD3+/CD25+, ratio of CD4+/CD8+, the plasma levels of IgA, IgM, and IgG at 20 days after nutritional treatment were significantly increased compared to the baseline(t=4.32-30.00, P{\textless}0.01), and they were significantly higher than those of PN group (t=2.44-14.70; P{\textless}0.05, or P{\textless}0.01) with exception of CD4+/CD8+, higher than those of EN group (t=2.49-13.31, P{\textless}0.05, or P{\textless}0.01) with exceptions of CD3+/CD25+, CD4+/CD8+, IgG and IgM. For the nutritional status, the serum total protein, albumin, prealbumin and hemoglobin were significantly higher in the EN (t=5.87-11.91; P{\textless}0.01) and EN+PN groups (t=6.12-13.12; P{\textless}0.01) than those in PN group after nutrition treatment. The serum prealbumin was higher in EN+PN group than that in EN group (t=2.08; P{\textless}0.05). Compared to the PN group, the complication occurrence rates of EN+PN group were significantly lower in stress ulcer (22.5\% vs. 47.5\%; chi2= 8.24, P{\textless}0.01), intracranial infection (12.5\% vs 32.5\%;chi2= 6.88, P{\textless}0.01) and pyemia (25.0\% vs. 47.5\%; chi2= 6.57, P{\textless}0.05). Compared to the EN group, the complication occurrence rates of EN+PN group were significantly lower in aspirated pneumonia (27.5\% vs. 50.0\%; chi2= 6.39, P{\textless}0.05), hypoproteinemia (17.5\% vs. 55.0\%; chi2= 18.26, P{\textless}0.01) and diarrhea (20.0\% vs. 60.0\%; chi2 = 20.00, P{\textless}0.01). The EN+PN group also had significant less length of stay in NICU (t=2.51, 4.82; P{\textless}0.05, P{\textless}0.01), number of patients receiving assisted mechanical ventilation (chi2= 6.08, 12.88; P{\textless}0.05, P{\textless}0.01) and its durations (t=3.41, 9.08; P{\textless}0.05, P{\textless}0.01), and the death rate (chi2=7.50, 16.37; P{\textless}0.05, P{\textless}0.01) than those of EN or PN group. Conclusion Early EN+PN treatment could promote the recovery of the immune function, enhance nutritional status, decrease complications and improve the clinical outcomes in patients with severe traumatic brain injury. Copyright © 2016 Chinese Academy Medical Sciences},
	journal = {Chinese Medical Sciences Journal},
	author = {{Fan M.-C.} and {Wang Q.-L.} and {Fang W.} and {Jiang Y.-X.} and {Li L.-D.} and {Sun P.} and {Wang Z.-H.}},
	year = {2016},
	keywords = {*enteric feeding, *nutritional status, *parenteral nutrition, *traumatic brain injury, CD25+ T lymphocyte, CD3 CD25 ratio, CD3 antigen, CD3 antigen/ec [Endogenous Compound], CD3+ T lymphocyte, CD4 CD8 ratio, CD4 antigen, CD4 antigen/ec [Endogenous Compound], CD4+ T lymphocyte, CD8 antigen/ec [Endogenous Compound], adolescent, adult, albumin, albumin/ec [Endogenous Compound], article, artificial ventilation, brain infection, clinical outcome, complication, complication/co [Complication], controlled study, diarrhea, endogenous compound, female, gene expression, hemoglobin, hemoglobin/ec [Endogenous Compound], human, human tissue, hypoproteinemia, immune system, immunoglobulin A, immunoglobulin A/ec [Endogenous Compound], immunoglobulin G, immunoglobulin G/ec [Endogenous Compound], immunoglobulin M, immunoglobulin M/ec [Endogenous Compound], immunoglobulin blood level, infection, injury severity, interleukin 2 receptor alpha/ec [Endogenous Compound], length of stay, lymphocyte count, major clinical study, male, mortality rate, neurological intensive care unit, nutritional status, plasma, pneumonia, prealbumin, prealbumin/ec [Endogenous Compound], prospective study, protein, protein/ec [Endogenous Compound], randomized controlled trial, remission, skull, stress ulcer}
}

{"_id":"6ifGRNJ4HoBRSKyw3","bibbaseid":"fanmc-wangql-fangw-jiangyx-lild-sunp-wangzh-earlyenteralcombinedwithparenteralnutritiontreatmentforseveretraumaticbraininjuryeffectsonimmunefunctionnutritionalstatusandoutcomes-2016","downloads":0,"creationDate":"2017-05-12T20:20:58.224Z","title":"Early Enteral Combined with Parenteral Nutrition Treatment for Severe Traumatic Brain Injury: Effects on Immune Function, Nutritional Status and Outcomes","author_short":["Fan M.-C.","Wang Q.-L.","Fang W.","Jiang Y.-X.","Li L.-D.","Sun P.","Wang Z.-H."],"year":2016,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Early Enteral Combined with Parenteral Nutrition Treatment for Severe Traumatic Brain Injury: Effects on Immune Function, Nutritional Status and Outcomes","url":"http://www.elsevier.com/wps/find/journaldescription.cws_home/722893/description#description","abstract":"Objective To compare the conjoint effect of enteral nutrition (EN) and parenteral nutrition (PN) with single EN or PN on immune function, nutritional status, complications and clinical outcomes of patients with severe traumatic brain injury (STBI). Methods A prospective randomized control trial was carried out from January 2009 to May 2012 in Neurological Intensive Care Unit (NICU). Patients of STBI who met the enrolment criteria (Glasgow Coma Scale score 6\\textasciitilde8; Nutritional Risk Screening \\textgreater 3) were randomly divided into 3 groups and were administrated EN, PN or EN + PN treatments respectively. The indexes of nutritional status, immune function, complications and clinical outcomes were examined and compared statistically. Results There were 120 patients enrolled in the study, with 40 pationts in each group. In EN+PN group, T lymthocyte subsets CD3+%, CD4+%, ratio of CD3+/CD25+, ratio of CD4+/CD8+, the plasma levels of IgA, IgM, and IgG at 20 days after nutritional treatment were significantly increased compared to the baseline(t=4.32-30.00, P\\textless0.01), and they were significantly higher than those of PN group (t=2.44-14.70; P\\textless0.05, or P\\textless0.01) with exception of CD4+/CD8+, higher than those of EN group (t=2.49-13.31, P\\textless0.05, or P\\textless0.01) with exceptions of CD3+/CD25+, CD4+/CD8+, IgG and IgM. For the nutritional status, the serum total protein, albumin, prealbumin and hemoglobin were significantly higher in the EN (t=5.87-11.91; P\\textless0.01) and EN+PN groups (t=6.12-13.12; P\\textless0.01) than those in PN group after nutrition treatment. The serum prealbumin was higher in EN+PN group than that in EN group (t=2.08; P\\textless0.05). Compared to the PN group, the complication occurrence rates of EN+PN group were significantly lower in stress ulcer (22.5% vs. 47.5%; chi2= 8.24, P\\textless0.01), intracranial infection (12.5% vs 32.5%;chi2= 6.88, P\\textless0.01) and pyemia (25.0% vs. 47.5%; chi2= 6.57, P\\textless0.05). Compared to the EN group, the complication occurrence rates of EN+PN group were significantly lower in aspirated pneumonia (27.5% vs. 50.0%; chi2= 6.39, P\\textless0.05), hypoproteinemia (17.5% vs. 55.0%; chi2= 18.26, P\\textless0.01) and diarrhea (20.0% vs. 60.0%; chi2 = 20.00, P\\textless0.01). The EN+PN group also had significant less length of stay in NICU (t=2.51, 4.82; P\\textless0.05, P\\textless0.01), number of patients receiving assisted mechanical ventilation (chi2= 6.08, 12.88; P\\textless0.05, P\\textless0.01) and its durations (t=3.41, 9.08; P\\textless0.05, P\\textless0.01), and the death rate (chi2=7.50, 16.37; P\\textless0.05, P\\textless0.01) than those of EN or PN group. Conclusion Early EN+PN treatment could promote the recovery of the immune function, enhance nutritional status, decrease complications and improve the clinical outcomes in patients with severe traumatic brain injury. Copyright © 2016 Chinese Academy Medical Sciences","journal":"Chinese Medical Sciences Journal","author":[{"firstnames":[],"propositions":[],"lastnames":["Fan M.-C."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Wang Q.-L."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Fang W."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Jiang Y.-X."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Li L.-D."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Sun P."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Wang Z.-H."],"suffixes":[]}],"year":"2016","keywords":"*enteric feeding, *nutritional status, *parenteral nutrition, *traumatic brain injury, CD25+ T lymphocyte, CD3 CD25 ratio, CD3 antigen, CD3 antigen/ec [Endogenous Compound], CD3+ T lymphocyte, CD4 CD8 ratio, CD4 antigen, CD4 antigen/ec [Endogenous Compound], CD4+ T lymphocyte, CD8 antigen/ec [Endogenous Compound], adolescent, adult, albumin, albumin/ec [Endogenous Compound], article, artificial ventilation, brain infection, clinical outcome, complication, complication/co [Complication], controlled study, diarrhea, endogenous compound, female, gene expression, hemoglobin, hemoglobin/ec [Endogenous Compound], human, human tissue, hypoproteinemia, immune system, immunoglobulin A, immunoglobulin A/ec [Endogenous Compound], immunoglobulin G, immunoglobulin G/ec [Endogenous Compound], immunoglobulin M, immunoglobulin M/ec [Endogenous Compound], immunoglobulin blood level, infection, injury severity, interleukin 2 receptor alpha/ec [Endogenous Compound], length of stay, lymphocyte count, major clinical study, male, mortality rate, neurological intensive care unit, nutritional status, plasma, pneumonia, prealbumin, prealbumin/ec [Endogenous Compound], prospective study, protein, protein/ec [Endogenous Compound], randomized controlled trial, remission, skull, stress ulcer","bibtex":"@misc{fan_m.-c._early_2016,\n\ttitle = {Early {Enteral} {Combined} with {Parenteral} {Nutrition} {Treatment} for {Severe} {Traumatic} {Brain} {Injury}: {Effects} on {Immune} {Function}, {Nutritional} {Status} and {Outcomes}},\n\turl = {http://www.elsevier.com/wps/find/journaldescription.cws_home/722893/description#description},\n\tabstract = {Objective To compare the conjoint effect of enteral nutrition (EN) and parenteral nutrition (PN) with single EN or PN on immune function, nutritional status, complications and clinical outcomes of patients with severe traumatic brain injury (STBI). Methods A prospective randomized control trial was carried out from January 2009 to May 2012 in Neurological Intensive Care Unit (NICU). Patients of STBI who met the enrolment criteria (Glasgow Coma Scale score 6{\\textasciitilde}8; Nutritional Risk Screening {\\textgreater} 3) were randomly divided into 3 groups and were administrated EN, PN or EN + PN treatments respectively. The indexes of nutritional status, immune function, complications and clinical outcomes were examined and compared statistically. Results There were 120 patients enrolled in the study, with 40 pationts in each group. In EN+PN group, T lymthocyte subsets CD3+\\%, CD4+\\%, ratio of CD3+/CD25+, ratio of CD4+/CD8+, the plasma levels of IgA, IgM, and IgG at 20 days after nutritional treatment were significantly increased compared to the baseline(t=4.32-30.00, P{\\textless}0.01), and they were significantly higher than those of PN group (t=2.44-14.70; P{\\textless}0.05, or P{\\textless}0.01) with exception of CD4+/CD8+, higher than those of EN group (t=2.49-13.31, P{\\textless}0.05, or P{\\textless}0.01) with exceptions of CD3+/CD25+, CD4+/CD8+, IgG and IgM. For the nutritional status, the serum total protein, albumin, prealbumin and hemoglobin were significantly higher in the EN (t=5.87-11.91; P{\\textless}0.01) and EN+PN groups (t=6.12-13.12; P{\\textless}0.01) than those in PN group after nutrition treatment. The serum prealbumin was higher in EN+PN group than that in EN group (t=2.08; P{\\textless}0.05). Compared to the PN group, the complication occurrence rates of EN+PN group were significantly lower in stress ulcer (22.5\\% vs. 47.5\\%; chi2= 8.24, P{\\textless}0.01), intracranial infection (12.5\\% vs 32.5\\%;chi2= 6.88, P{\\textless}0.01) and pyemia (25.0\\% vs. 47.5\\%; chi2= 6.57, P{\\textless}0.05). Compared to the EN group, the complication occurrence rates of EN+PN group were significantly lower in aspirated pneumonia (27.5\\% vs. 50.0\\%; chi2= 6.39, P{\\textless}0.05), hypoproteinemia (17.5\\% vs. 55.0\\%; chi2= 18.26, P{\\textless}0.01) and diarrhea (20.0\\% vs. 60.0\\%; chi2 = 20.00, P{\\textless}0.01). The EN+PN group also had significant less length of stay in NICU (t=2.51, 4.82; P{\\textless}0.05, P{\\textless}0.01), number of patients receiving assisted mechanical ventilation (chi2= 6.08, 12.88; P{\\textless}0.05, P{\\textless}0.01) and its durations (t=3.41, 9.08; P{\\textless}0.05, P{\\textless}0.01), and the death rate (chi2=7.50, 16.37; P{\\textless}0.05, P{\\textless}0.01) than those of EN or PN group. Conclusion Early EN+PN treatment could promote the recovery of the immune function, enhance nutritional status, decrease complications and improve the clinical outcomes in patients with severe traumatic brain injury. Copyright © 2016 Chinese Academy Medical Sciences},\n\tjournal = {Chinese Medical Sciences Journal},\n\tauthor = {{Fan M.-C.} and {Wang Q.-L.} and {Fang W.} and {Jiang Y.-X.} and {Li L.-D.} and {Sun P.} and {Wang Z.-H.}},\n\tyear = {2016},\n\tkeywords = {*enteric feeding, *nutritional status, *parenteral nutrition, *traumatic brain injury, CD25+ T lymphocyte, CD3 CD25 ratio, CD3 antigen, CD3 antigen/ec [Endogenous Compound], CD3+ T lymphocyte, CD4 CD8 ratio, CD4 antigen, CD4 antigen/ec [Endogenous Compound], CD4+ T lymphocyte, CD8 antigen/ec [Endogenous Compound], adolescent, adult, albumin, albumin/ec [Endogenous Compound], article, artificial ventilation, brain infection, clinical outcome, complication, complication/co [Complication], controlled study, diarrhea, endogenous compound, female, gene expression, hemoglobin, hemoglobin/ec [Endogenous Compound], human, human tissue, hypoproteinemia, immune system, immunoglobulin A, immunoglobulin A/ec [Endogenous Compound], immunoglobulin G, immunoglobulin G/ec [Endogenous Compound], immunoglobulin M, immunoglobulin M/ec [Endogenous Compound], immunoglobulin blood level, infection, injury severity, interleukin 2 receptor alpha/ec [Endogenous Compound], length of stay, lymphocyte count, major clinical study, male, mortality rate, neurological intensive care unit, nutritional status, plasma, pneumonia, prealbumin, prealbumin/ec [Endogenous Compound], prospective study, protein, protein/ec [Endogenous Compound], randomized controlled trial, remission, skull, stress ulcer}\n}\n\n","author_short":["Fan M.-C.","Wang Q.-L.","Fang W.","Jiang Y.-X.","Li L.-D.","Sun P.","Wang Z.-H."],"key":"fan_m.-c._early_2016","id":"fan_m.-c._early_2016","bibbaseid":"fanmc-wangql-fangw-jiangyx-lild-sunp-wangzh-earlyenteralcombinedwithparenteralnutritiontreatmentforseveretraumaticbraininjuryeffectsonimmunefunctionnutritionalstatusandoutcomes-2016","role":"author","urls":{"Paper":"http://www.elsevier.com/wps/find/journaldescription.cws_home/722893/description#description"},"keyword":["*enteric feeding","*nutritional status","*parenteral nutrition","*traumatic brain injury","CD25+ T lymphocyte","CD3 CD25 ratio","CD3 antigen","CD3 antigen/ec [Endogenous Compound]","CD3+ T lymphocyte","CD4 CD8 ratio","CD4 antigen","CD4 antigen/ec [Endogenous Compound]","CD4+ T lymphocyte","CD8 antigen/ec [Endogenous Compound]","adolescent","adult","albumin","albumin/ec [Endogenous Compound]","article","artificial ventilation","brain infection","clinical outcome","complication","complication/co [Complication]","controlled study","diarrhea","endogenous compound","female","gene 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