A case for promoting movement medicine: preventing disability in the LIFE randomized controlled trial. Fanning, J., Rejeski, W J., Chen, S., Nicklas, B. J, Walkup, M. P, Axtell, R. S, Fielding, R. A, Glynn, N. W, King, A. C, Manini, T. M, Mcdermott, M. M., Newman, A. B, Pahor, M., Tudorlocke, C., & Miller, M. I Journals of Gerontology Series A-biological Sciences and Medical Sciences, 74(11):1821–1827, 2019. Citation Key Alias: ISI:000491242600017, lens.org/077-007-606-131-474 tex.type: [object Object]![A case for promoting movement medicine: preventing disability in the LIFE randomized controlled trial [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background: The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD. Methods: Older adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured physical activity intervention or health education control. We assessed MMD in 6-month intervals (average follow-up of 2.2 years until incident MMD), with activity assessed at baseline, 6-, 12- and 24-month follow-up via accelerometry. Results: A principal components analysis of 11 accelerometer-derived metrics yielded three components representing lifestyle movement (LM), extended bouts of moderate-to-vigorous physical activity (MVPA), and stationary body posture. LM accounted for the greatest proportion of variance in movement (53%). Within health education, both baseline LM (HR = 0.74; 95% CI 0.62 to 0.88) and moderate-to-vigorous physical activity (HR = 0.69; 95% CI 0.54 to 0.87) were associated with MMD, whereas only LM was associated with MMD within physical activity (HR = 0.74; 95% CI 0.61 to 0.89). There were similar nonlinear relationships present for LM in both physical activity and health education (p ¡ .04), whereby risk for MMD was lower among individuals with higher levels of LM. Conclusions: Both LM and moderate-to-vigorous physical activity should be central in treatment regimens for older adults at risk for MMD.
@article{pop00036,
title = {A case for promoting movement medicine: preventing disability in the {LIFE} randomized controlled trial},
volume = {74},
issn = {1079-5006},
url = {https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glz050/5335754},
doi = {10.1093/gerona/glz050},
abstract = {Background: The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD. Methods: Older adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured physical activity intervention or health education control. We assessed MMD in 6-month intervals (average follow-up of 2.2 years until incident MMD), with activity assessed at baseline, 6-, 12- and 24-month follow-up via accelerometry. Results: A principal components analysis of 11 accelerometer-derived metrics yielded three components representing lifestyle movement (LM), extended bouts of moderate-to-vigorous physical activity (MVPA), and stationary body posture. LM accounted for the greatest proportion of variance in movement (53\%). Within health education, both baseline LM (HR = 0.74; 95\% CI 0.62 to 0.88) and moderate-to-vigorous physical activity (HR = 0.69; 95\% CI 0.54 to 0.87) were associated with MMD, whereas only LM was associated with MMD within physical activity (HR = 0.74; 95\% CI 0.61 to 0.89). There were similar nonlinear relationships present for LM in both physical activity and health education (p ¡ .04), whereby risk for MMD was lower among individuals with higher levels of LM. Conclusions: Both LM and moderate-to-vigorous physical activity should be central in treatment regimens for older adults at risk for MMD.},
number = {11},
journal = {Journals of Gerontology Series A-biological Sciences and Medical Sciences},
author = {Fanning, Jason and Rejeski, W Jack and Chen, Shyhhuei and Nicklas, Barbara J and Walkup, Michael P and Axtell, Robert S and Fielding, Roger A and Glynn, Nancy W and King, Abby C and Manini, Todd M and Mcdermott, Mary Mcgrae and Newman, Anne B and Pahor, Marco and Tudorlocke, Catrine and Miller, Michael I},
year = {2019},
note = {Citation Key Alias: ISI:000491242600017, lens.org/077-007-606-131-474
tex.type: [object Object]},
keywords = {Accelerometry, Disability, Exercise, Physical activity, Sedentary, dept.hms},
pages = {1821--1827}
}
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I"],"bibdata":{"bibtype":"article","type":"article","title":"A case for promoting movement medicine: preventing disability in the LIFE randomized controlled trial","volume":"74","issn":"1079-5006","url":"https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glz050/5335754","doi":"10.1093/gerona/glz050","abstract":"Background: The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD. Methods: Older adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured physical activity intervention or health education control. We assessed MMD in 6-month intervals (average follow-up of 2.2 years until incident MMD), with activity assessed at baseline, 6-, 12- and 24-month follow-up via accelerometry. Results: A principal components analysis of 11 accelerometer-derived metrics yielded three components representing lifestyle movement (LM), extended bouts of moderate-to-vigorous physical activity (MVPA), and stationary body posture. LM accounted for the greatest proportion of variance in movement (53%). Within health education, both baseline LM (HR = 0.74; 95% CI 0.62 to 0.88) and moderate-to-vigorous physical activity (HR = 0.69; 95% CI 0.54 to 0.87) were associated with MMD, whereas only LM was associated with MMD within physical activity (HR = 0.74; 95% CI 0.61 to 0.89). There were similar nonlinear relationships present for LM in both physical activity and health education (p ¡ .04), whereby risk for MMD was lower among individuals with higher levels of LM. Conclusions: Both LM and moderate-to-vigorous physical activity should be central in treatment regimens for older adults at risk for MMD.","number":"11","journal":"Journals of Gerontology Series A-biological Sciences and Medical Sciences","author":[{"propositions":[],"lastnames":["Fanning"],"firstnames":["Jason"],"suffixes":[]},{"propositions":[],"lastnames":["Rejeski"],"firstnames":["W","Jack"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Shyhhuei"],"suffixes":[]},{"propositions":[],"lastnames":["Nicklas"],"firstnames":["Barbara","J"],"suffixes":[]},{"propositions":[],"lastnames":["Walkup"],"firstnames":["Michael","P"],"suffixes":[]},{"propositions":[],"lastnames":["Axtell"],"firstnames":["Robert","S"],"suffixes":[]},{"propositions":[],"lastnames":["Fielding"],"firstnames":["Roger","A"],"suffixes":[]},{"propositions":[],"lastnames":["Glynn"],"firstnames":["Nancy","W"],"suffixes":[]},{"propositions":[],"lastnames":["King"],"firstnames":["Abby","C"],"suffixes":[]},{"propositions":[],"lastnames":["Manini"],"firstnames":["Todd","M"],"suffixes":[]},{"propositions":[],"lastnames":["Mcdermott"],"firstnames":["Mary","Mcgrae"],"suffixes":[]},{"propositions":[],"lastnames":["Newman"],"firstnames":["Anne","B"],"suffixes":[]},{"propositions":[],"lastnames":["Pahor"],"firstnames":["Marco"],"suffixes":[]},{"propositions":[],"lastnames":["Tudorlocke"],"firstnames":["Catrine"],"suffixes":[]},{"propositions":[],"lastnames":["Miller"],"firstnames":["Michael","I"],"suffixes":[]}],"year":"2019","note":"Citation Key Alias: ISI:000491242600017, lens.org/077-007-606-131-474 tex.type: [object Object]","keywords":"Accelerometry, Disability, Exercise, Physical activity, Sedentary, dept.hms","pages":"1821–1827","bibtex":"@article{pop00036,\n\ttitle = {A case for promoting movement medicine: preventing disability in the {LIFE} randomized controlled trial},\n\tvolume = {74},\n\tissn = {1079-5006},\n\turl = {https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glz050/5335754},\n\tdoi = {10.1093/gerona/glz050},\n\tabstract = {Background: The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD. Methods: Older adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured physical activity intervention or health education control. We assessed MMD in 6-month intervals (average follow-up of 2.2 years until incident MMD), with activity assessed at baseline, 6-, 12- and 24-month follow-up via accelerometry. Results: A principal components analysis of 11 accelerometer-derived metrics yielded three components representing lifestyle movement (LM), extended bouts of moderate-to-vigorous physical activity (MVPA), and stationary body posture. LM accounted for the greatest proportion of variance in movement (53\\%). Within health education, both baseline LM (HR = 0.74; 95\\% CI 0.62 to 0.88) and moderate-to-vigorous physical activity (HR = 0.69; 95\\% CI 0.54 to 0.87) were associated with MMD, whereas only LM was associated with MMD within physical activity (HR = 0.74; 95\\% CI 0.61 to 0.89). There were similar nonlinear relationships present for LM in both physical activity and health education (p ¡ .04), whereby risk for MMD was lower among individuals with higher levels of LM. 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