Nanoscale ion mediated networks in bone: Osteopontin can repeatedly dissipate large amounts of energy. Fantner, G. E, Adams, J., Turner, P., Thurner, P. J, Fisher, L. W, & Hansma, P. K Nano Letters, 7(8):2491–2498, 2007. ISBN: 1530-6984
Nanoscale ion mediated networks in bone: Osteopontin can repeatedly dissipate large amounts of energy [link]Paper  doi  abstract   bibtex   
In the nanocomposite bone, inorganic material is combined with several types of organic molecules, and these complexes have been proposed to increase the bone strength. Here we report on a mechanism of how one of these components, human osteopontin, forms large mechanical networks that can repeatedly dissipate energy through work against entropy by breaking sacrificial bonds and stretching hidden length. The behavior of these in vitro networks is similar to that of organic components in bone, acting as an adhesive layer in between mineralized fibrils.
@article{fantner_nanoscale_2007,
	title = {Nanoscale ion mediated networks in bone: {Osteopontin} can repeatedly dissipate large amounts of energy},
	volume = {7},
	issn = {15306984},
	url = {<Go to ISI>://WOS:000248657800057\nhttp://dx.doi.org/10.1021/nl0712769},
	doi = {Doi 10.1021/Nl0712769},
	abstract = {In the nanocomposite bone, inorganic material is combined with several types of organic molecules, and these complexes have been proposed to increase the bone strength. Here we report on a mechanism of how one of these components, human osteopontin, forms large mechanical networks that can repeatedly dissipate energy through work against entropy by breaking sacrificial bonds and stretching hidden length. The behavior of these in vitro networks is similar to that of organic components in bone, acting as an adhesive layer in between mineralized fibrils.},
	number = {8},
	journal = {Nano Letters},
	author = {Fantner, Georg E and Adams, Jonathan and Turner, Patricia and Thurner, Philipp J and Fisher, Larry W and Hansma, Paul K},
	year = {2007},
	pmid = {17645366},
	note = {ISBN: 1530-6984},
	keywords = {force spectroscopy, fracture, hidden length, in-vitro, organic matrix, proteins, sacrificial bonds, sialoprotein, toughness, trabecular bone},
	pages = {2491--2498},
}

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