Ex vivo confocal microscopy features of common benign lesions that mimic non-melanoma skin cancers: Towards clinical integration. Farabi, B., Atak, M. F., Harris, U., Kahn, J., Khan, S., Fink, V., Hartmann, D., Rao, B. K., & Jain, M. Journal of Biophotonics, 17(4):e202300386, April, 2024. doi abstract bibtex Ex vivo confocal microscope (EVCM) rapidly images freshly excised tissue at a histopathological resolution. EVCM features of keratinocyte skin cancers are well-established, but those of benign clinical mimickers remain scarce. We describe EVCM features of common benign lesions and compare them with their malignant differentials. EVCM was used to image 14 benign and 3 cancer tissues. We compared EVCM features of benign lesions with corresponding histopathology and with those of keratinocyte cancers. Key features of benign lesions were identified and differentiated from malignant lesions. Elastin and fat appeared prominent in EVCM; while koilocytes and melanin were difficult to identify. Visualization of entire epidermis was challenging due to difficulty of tissue flattening during imaging. Benign lesions can be differentiated from keratinocyte cancers with EVCM. Using EVCM, a rapid, bedside diagnosis and management of skin neoplasms is possible, especially in a remote location without a histopathology lab.
@article{farabi_ex_2024,
title = {Ex vivo confocal microscopy features of common benign lesions that mimic non-melanoma skin cancers: {Towards} clinical integration},
volume = {17},
issn = {1864-0648},
shorttitle = {Ex vivo confocal microscopy features of common benign lesions that mimic non-melanoma skin cancers},
doi = {10.1002/jbio.202300386},
abstract = {Ex vivo confocal microscope (EVCM) rapidly images freshly excised tissue at a histopathological resolution. EVCM features of keratinocyte skin cancers are well-established, but those of benign clinical mimickers remain scarce. We describe EVCM features of common benign lesions and compare them with their malignant differentials. EVCM was used to image 14 benign and 3 cancer tissues. We compared EVCM features of benign lesions with corresponding histopathology and with those of keratinocyte cancers. Key features of benign lesions were identified and differentiated from malignant lesions. Elastin and fat appeared prominent in EVCM; while koilocytes and melanin were difficult to identify. Visualization of entire epidermis was challenging due to difficulty of tissue flattening during imaging. Benign lesions can be differentiated from keratinocyte cancers with EVCM. Using EVCM, a rapid, bedside diagnosis and management of skin neoplasms is possible, especially in a remote location without a histopathology lab.},
language = {eng},
number = {4},
journal = {Journal of Biophotonics},
author = {Farabi, Banu and Atak, Mehmet Fatih and Harris, Ucalene and Kahn, Julia and Khan, Samavia and Fink, Veronica and Hartmann, Daniella and Rao, Babar K. and Jain, Manu},
month = apr,
year = {2024},
pmid = {38200691},
keywords = {Epidermis, Humans, Keratinocytes, Melanins, Microscopy, Confocal, Skin Neoplasms, benign skin lesions, digital‐H\&E images, ex vivo confocal microscopy, histopathology, nonmelanocytic skin lesions},
pages = {e202300386},
}
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We describe EVCM features of common benign lesions and compare them with their malignant differentials. EVCM was used to image 14 benign and 3 cancer tissues. We compared EVCM features of benign lesions with corresponding histopathology and with those of keratinocyte cancers. Key features of benign lesions were identified and differentiated from malignant lesions. Elastin and fat appeared prominent in EVCM; while koilocytes and melanin were difficult to identify. Visualization of entire epidermis was challenging due to difficulty of tissue flattening during imaging. Benign lesions can be differentiated from keratinocyte cancers with EVCM. Using EVCM, a rapid, bedside diagnosis and management of skin neoplasms is possible, especially in a remote location without a histopathology lab.","language":"eng","number":"4","journal":"Journal of Biophotonics","author":[{"propositions":[],"lastnames":["Farabi"],"firstnames":["Banu"],"suffixes":[]},{"propositions":[],"lastnames":["Atak"],"firstnames":["Mehmet","Fatih"],"suffixes":[]},{"propositions":[],"lastnames":["Harris"],"firstnames":["Ucalene"],"suffixes":[]},{"propositions":[],"lastnames":["Kahn"],"firstnames":["Julia"],"suffixes":[]},{"propositions":[],"lastnames":["Khan"],"firstnames":["Samavia"],"suffixes":[]},{"propositions":[],"lastnames":["Fink"],"firstnames":["Veronica"],"suffixes":[]},{"propositions":[],"lastnames":["Hartmann"],"firstnames":["Daniella"],"suffixes":[]},{"propositions":[],"lastnames":["Rao"],"firstnames":["Babar","K."],"suffixes":[]},{"propositions":[],"lastnames":["Jain"],"firstnames":["Manu"],"suffixes":[]}],"month":"April","year":"2024","pmid":"38200691","keywords":"Epidermis, Humans, Keratinocytes, Melanins, Microscopy, Confocal, Skin Neoplasms, benign skin lesions, digital‐H&E images, ex vivo confocal microscopy, histopathology, nonmelanocytic skin lesions","pages":"e202300386","bibtex":"@article{farabi_ex_2024,\n\ttitle = {Ex vivo confocal microscopy features of common benign lesions that mimic non-melanoma skin cancers: {Towards} clinical integration},\n\tvolume = {17},\n\tissn = {1864-0648},\n\tshorttitle = {Ex vivo confocal microscopy features of common benign lesions that mimic non-melanoma skin cancers},\n\tdoi = {10.1002/jbio.202300386},\n\tabstract = {Ex vivo confocal microscope (EVCM) rapidly images freshly excised tissue at a histopathological resolution. EVCM features of keratinocyte skin cancers are well-established, but those of benign clinical mimickers remain scarce. We describe EVCM features of common benign lesions and compare them with their malignant differentials. EVCM was used to image 14 benign and 3 cancer tissues. We compared EVCM features of benign lesions with corresponding histopathology and with those of keratinocyte cancers. Key features of benign lesions were identified and differentiated from malignant lesions. Elastin and fat appeared prominent in EVCM; while koilocytes and melanin were difficult to identify. Visualization of entire epidermis was challenging due to difficulty of tissue flattening during imaging. Benign lesions can be differentiated from keratinocyte cancers with EVCM. 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