. Faraco, V., Balan, V., Jin, M., Culbertson, A., & Uppugundla, N. The saccharification step: Trichoderma reesei cellulase hyper producer strains., pages 65-92. Springer, Heidelberg, 2013.
The saccharification step: Trichoderma reesei cellulase hyper producer strains. [link]Paper  doi  abstract   bibtex   
One of the major applications of cellulases is to produce fermentable sugars from lignocellulosic biomass to produce biofuels. Filamentous fungus Trichoderma reesei is known to be hyper producer of enzymes and is widely used for commercial scale production of cellulases and hemicellulases using novel fermentation techniques. Some of the current T. reesei industrial strains produce over 100g/l of cellulases. However, there are still technical and economic constraints to the development of cheap commercial cellulase production process. Here, we bring together and discuss the results of T. reesei as a cellulase producer, the different kinds of enzymes it expresses, recent genomic, genetic and metabolic engineering approaches that have helped to improve the biomass degrading enzyme mixture and strategies followed to reduce the cost of enzymes during fermentation process. Some future perspectives for reducing the cost of enzymes by using pretreated biomass as substrate, recycling enzyme during the hydrolysis and fermentation process and on-site enzyme production in the biorefinery facility are also discussed.
@inbook{Faraco:2013aa,
	Abstract = {One of the major applications of cellulases is to produce fermentable sugars from lignocellulosic biomass to produce biofuels. Filamentous fungus Trichoderma reesei is known to be hyper producer of enzymes and is widely used for commercial scale production of cellulases and hemicellulases using novel fermentation techniques. Some of the current T. reesei industrial strains produce over 100g/l of cellulases. However, there are still technical and economic constraints to the development of cheap commercial cellulase production process. Here, we bring together and discuss the results of T. reesei as a cellulase producer, the different kinds of enzymes it expresses, recent genomic, genetic and metabolic engineering approaches that have helped to improve the biomass degrading enzyme mixture and strategies followed to reduce the cost of enzymes during fermentation process. Some future perspectives for reducing the cost of enzymes by using pretreated biomass as substrate, recycling enzyme during the hydrolysis and fermentation process and on-site enzyme production in the biorefinery facility are also discussed.},
	Address = {Heidelberg},
	Annote = {FL verified in pdf as submitted - 4/8/13 SLM},
	Author = {Faraco, Vincenza and Balan, Venkatesh and Jin, Mingjie and Culbertson, Alan and Uppugundla, Nirmal},
	Booktitle = {Lignocellulose Conversion: Enzymatic and Microbial Tools for Bioethanol Production},
	Date-Added = {2017-11-17 17:51:47 +0000},
	Date-Modified = {2017-11-17 17:51:47 +0000},
	Doi = {10.1007/978-3-642-37861-4},
	Id = {59},
	Isbn = {978-3-642-37860-7},
	Lb = {A2, Y6Q3 (June 30, 2013)},
	Local-Url = {internal-pdf://3617318129/Balan_Uppugundla_Book_2013.pdf},
	Pages = {65-92},
	Publisher = {Springer},
	Rn = {2.2.4.2 2.5.1},
	Se = {4},
	St = {The saccharification step: Trichoderma reesei cellulase hyper producer strains.},
	Title = {The saccharification step: Trichoderma reesei cellulase hyper producer strains.},
	Ty = {CHAP},
	Url = {http://www.springer.com/new+%26+forthcoming+titles+%28default%29/book/978-3-642-37860-7},
	Year = {2013},
	Bdsk-Url-1 = {http://www.springer.com/new+%26+forthcoming+titles+%28default%29/book/978-3-642-37860-7},
	Bdsk-Url-2 = {http://dx.doi.org/10.1007/978-3-642-37861-4}}
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