@article{farrell_adenotonsillectomy_2018,
	title = {Adenotonsillectomy in children with sickle cell disease and obstructive sleep apnea},
	volume = {111},
	issn = {1872-8464},
	doi = {10.1016/j.ijporl.2018.05.034},
	abstract = {INTRODUCTION: Obstructive sleep apnea (OSA) is prevalent and may be more severe in children with Sickle Cell Disease (SCD) compared to the general pediatric population.
OBJECTIVES: The objective of this study was to describe the therapeutic effects and complications of tonsillectomy and adenoidectomy (T\&A) for treatment of OSA in children with SCD.
METHODS: A comprehensive database of pediatric SCD patients was reviewed to identify all patients who underwent T\&A between 2010 and 2016. An IRB-approved, retrospective review of laboratory values, perioperative course, pre- and post-T\&A hospital utilization, and polysomnography was conducted.
RESULTS: There were 132 SCD children (108 HbSS) who underwent T\&A. Mean age was 7.6 ± 4.6 years. The mean baseline hemoglobin of these patients was 9.3 ± 1.4 g/dL; 72.7\% of patients had pre-operative transfusion, such that the mean Hb at time of T\&A was 11.4 ± 1.0 g/dL. The average admission length surrounding T\&A was 3.5 ± 1.2 days. Complications were documented in 11.4\% of operative cases. Polysomnography was available in 104 pre-T\&A and 45 post-T\&A. The Apnea-Hypopnea Index decreased on post-T\&A polysomnogram (7.6 ± 8.7 vs. 1.3 ± 1.9, p = 0.0001). The O2 nadir improved on post-T\&A polysomnogram (81.2 ± 10.8 vs. 89.3 ± 7, p = 0.0003). Emergency room visits (mean events per year) decreased post-operatively (2.6 ± 2.8 vs. 1.8 ± 2.2, p = 0.0002).
CONCLUSIONS: T\&A can be a safe and effective option to treat OSA in pediatric patients with SCD and was significantly associated with reduced AHI and fewer ER visits post-operatively.},
	language = {eng},
	journal = {International Journal of Pediatric Otorhinolaryngology},
	author = {Farrell, Annie N. and Goudy, Steven L. and Yee, Marianne E. and Leu, Roberta M. and Landry, April M.},
	month = aug,
	year = {2018},
	pmid = {29958601},
	pmcid = {PMC6408690},
	keywords = {Adenoidectomy, Adolescent, Anemia, Sickle Cell, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Polysomnography, Postoperative Complications, Retrospective Studies, Sleep Apnea, Obstructive, Tonsillectomy, Treatment Outcome},
	pages = {158--161}
}

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OBJECTIVES: The objective of this study was to describe the therapeutic effects and complications of tonsillectomy and adenoidectomy (T&A) for treatment of OSA in children with SCD. METHODS: A comprehensive database of pediatric SCD patients was reviewed to identify all patients who underwent T&A between 2010 and 2016. An IRB-approved, retrospective review of laboratory values, perioperative course, pre- and post-T&A hospital utilization, and polysomnography was conducted. RESULTS: There were 132 SCD children (108 HbSS) who underwent T&A. Mean age was 7.6 ± 4.6 years. The mean baseline hemoglobin of these patients was 9.3 ± 1.4 g/dL; 72.7% of patients had pre-operative transfusion, such that the mean Hb at time of T&A was 11.4 ± 1.0 g/dL. The average admission length surrounding T&A was 3.5 ± 1.2 days. Complications were documented in 11.4% of operative cases. Polysomnography was available in 104 pre-T&A and 45 post-T&A. The Apnea-Hypopnea Index decreased on post-T&A polysomnogram (7.6 ± 8.7 vs. 1.3 ± 1.9, p = 0.0001). The O2 nadir improved on post-T&A polysomnogram (81.2 ± 10.8 vs. 89.3 ± 7, p = 0.0003). Emergency room visits (mean events per year) decreased post-operatively (2.6 ± 2.8 vs. 1.8 ± 2.2, p = 0.0002). CONCLUSIONS: T&A can be a safe and effective option to treat OSA in pediatric patients with SCD and was significantly associated with reduced AHI and fewer ER visits post-operatively.","language":"eng","journal":"International Journal of Pediatric Otorhinolaryngology","author":[{"propositions":[],"lastnames":["Farrell"],"firstnames":["Annie","N."],"suffixes":[]},{"propositions":[],"lastnames":["Goudy"],"firstnames":["Steven","L."],"suffixes":[]},{"propositions":[],"lastnames":["Yee"],"firstnames":["Marianne","E."],"suffixes":[]},{"propositions":[],"lastnames":["Leu"],"firstnames":["Roberta","M."],"suffixes":[]},{"propositions":[],"lastnames":["Landry"],"firstnames":["April","M."],"suffixes":[]}],"month":"August","year":"2018","pmid":"29958601","pmcid":"PMC6408690","keywords":"Adenoidectomy, Adolescent, Anemia, Sickle Cell, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Polysomnography, Postoperative Complications, Retrospective Studies, Sleep Apnea, Obstructive, Tonsillectomy, Treatment Outcome","pages":"158–161","bibtex":"@article{farrell_adenotonsillectomy_2018,\n\ttitle = {Adenotonsillectomy in children with sickle cell disease and obstructive sleep apnea},\n\tvolume = {111},\n\tissn = {1872-8464},\n\tdoi = {10.1016/j.ijporl.2018.05.034},\n\tabstract = {INTRODUCTION: Obstructive sleep apnea (OSA) is prevalent and may be more severe in children with Sickle Cell Disease (SCD) compared to the general pediatric population.\nOBJECTIVES: The objective of this study was to describe the therapeutic effects and complications of tonsillectomy and adenoidectomy (T\\&A) for treatment of OSA in children with SCD.\nMETHODS: A comprehensive database of pediatric SCD patients was reviewed to identify all patients who underwent T\\&A between 2010 and 2016. An IRB-approved, retrospective review of laboratory values, perioperative course, pre- and post-T\\&A hospital utilization, and polysomnography was conducted.\nRESULTS: There were 132 SCD children (108 HbSS) who underwent T\\&A. Mean age was 7.6 ± 4.6 years. The mean baseline hemoglobin of these patients was 9.3 ± 1.4 g/dL; 72.7\\% of patients had pre-operative transfusion, such that the mean Hb at time of T\\&A was 11.4 ± 1.0 g/dL. The average admission length surrounding T\\&A was 3.5 ± 1.2 days. Complications were documented in 11.4\\% of operative cases. Polysomnography was available in 104 pre-T\\&A and 45 post-T\\&A. The Apnea-Hypopnea Index decreased on post-T\\&A polysomnogram (7.6 ± 8.7 vs. 1.3 ± 1.9, p = 0.0001). The O2 nadir improved on post-T\\&A polysomnogram (81.2 ± 10.8 vs. 89.3 ± 7, p = 0.0003). Emergency room visits (mean events per year) decreased post-operatively (2.6 ± 2.8 vs. 1.8 ± 2.2, p = 0.0002).\nCONCLUSIONS: T\\&A can be a safe and effective option to treat OSA in pediatric patients with SCD and was significantly associated with reduced AHI and fewer ER visits post-operatively.},\n\tlanguage = {eng},\n\tjournal = {International Journal of Pediatric Otorhinolaryngology},\n\tauthor = {Farrell, Annie N. and Goudy, Steven L. and Yee, Marianne E. and Leu, Roberta M. and Landry, April M.},\n\tmonth = aug,\n\tyear = {2018},\n\tpmid = {29958601},\n\tpmcid = {PMC6408690},\n\tkeywords = {Adenoidectomy, Adolescent, Anemia, Sickle Cell, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Polysomnography, Postoperative Complications, Retrospective Studies, Sleep Apnea, Obstructive, Tonsillectomy, Treatment Outcome},\n\tpages = {158--161}\n}\n\n","author_short":["Farrell, A. N.","Goudy, S. L.","Yee, M. E.","Leu, R. M.","Landry, A. 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