@article{
 title = {Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals},
 type = {article},
 year = {2019},
 identifiers = {[object Object]},
 pages = {2285-2293},
 volume = {44},
 websites = {http://www.nature.com/articles/s41386-019-0485-6},
 month = {12},
 day = {21},
 id = {c9d4a3c6-4ddf-3134-8f75-7a53c853979e},
 created = {2020-09-30T16:35:04.161Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-30T16:35:04.161Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R2 = 0.041, Pcorr < 0.001) and cingulum (right: R2 = 0.041, left: R2 = 0.040, Pcorr < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.},
 bibtype = {article},
 author = {Favre, Pauline and Pauling, Melissa and Stout, Jacques and Hozer, Franz and Sarrazin, Samuel and Abé, Christoph and Alda, Martin and Alloza, Clara and Alonso-Lana, Silvia and Andreassen, Ole A. and Baune, Bernhard T. and Benedetti, Francesco and Busatto, Geraldo F. and Canales-Rodríguez, Erick J. and Caseras, Xavier and Chaim-Avancini, Tiffany Moukbel and Ching, Christopher R. K. and Dannlowski, Udo and Deppe, Michael and Eyler, Lisa T. and Fatjo-Vilas, Mar and Foley, Sonya F. and Grotegerd, Dominik and Hajek, Tomas and Haukvik, Unn K. and Howells, Fleur M. and Jahanshad, Neda and Kugel, Harald and Lagerberg, Trine V. and Lawrie, Stephen M. and Linke, Julia O. and McIntosh, Andrew and Melloni, Elisa M. T. and Mitchell, Philip B. and Polosan, Mircea and Pomarol-Clotet, Edith and Repple, Jonathan and Roberts, Gloria and Roos, Annerine and Rosa, Pedro G. P. and Salvador, Raymond and Sarró, Salvador and Schofield, Peter R. and Serpa, Mauricio H. and Sim, Kang and Stein, Dan J. and Sussmann, Jess E. and Temmingh, Henk S. and Thompson, Paul M. and Verdolini, Norma and Vieta, Eduard and Wessa, Michele and Whalley, Heather C. and Zanetti, Marcus V. and Leboyer, Marion and Mangin, Jean-François and Henry, Chantal and Duchesnay, Edouard and Houenou, Josselin},
 journal = {Neuropsychopharmacology},
 number = {13}
}

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This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R2 = 0.041, Pcorr < 0.001) and cingulum (right: R2 = 0.041, left: R2 = 0.040, Pcorr < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.","bibtype":"article","author":"Favre, Pauline and Pauling, Melissa and Stout, Jacques and Hozer, Franz and Sarrazin, Samuel and Abé, Christoph and Alda, Martin and Alloza, Clara and Alonso-Lana, Silvia and Andreassen, Ole A. and Baune, Bernhard T. and Benedetti, Francesco and Busatto, Geraldo F. and Canales-Rodríguez, Erick J. and Caseras, Xavier and Chaim-Avancini, Tiffany Moukbel and Ching, Christopher R. K. and Dannlowski, Udo and Deppe, Michael and Eyler, Lisa T. and Fatjo-Vilas, Mar and Foley, Sonya F. and Grotegerd, Dominik and Hajek, Tomas and Haukvik, Unn K. and Howells, Fleur M. and Jahanshad, Neda and Kugel, Harald and Lagerberg, Trine V. and Lawrie, Stephen M. and Linke, Julia O. and McIntosh, Andrew and Melloni, Elisa M. T. and Mitchell, Philip B. and Polosan, Mircea and Pomarol-Clotet, Edith and Repple, Jonathan and Roberts, Gloria and Roos, Annerine and Rosa, Pedro G. P. and Salvador, Raymond and Sarró, Salvador and Schofield, Peter R. and Serpa, Mauricio H. and Sim, Kang and Stein, Dan J. and Sussmann, Jess E. and Temmingh, Henk S. and Thompson, Paul M. and Verdolini, Norma and Vieta, Eduard and Wessa, Michele and Whalley, Heather C. and Zanetti, Marcus V. and Leboyer, Marion and Mangin, Jean-François and Henry, Chantal and Duchesnay, Edouard and Houenou, Josselin","journal":"Neuropsychopharmacology","number":"13","bibtex":"@article{\n title = {Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals},\n type = {article},\n year = {2019},\n identifiers = {[object Object]},\n pages = {2285-2293},\n volume = {44},\n websites = {http://www.nature.com/articles/s41386-019-0485-6},\n month = {12},\n day = {21},\n id = {c9d4a3c6-4ddf-3134-8f75-7a53c853979e},\n created = {2020-09-30T16:35:04.161Z},\n file_attached = {false},\n profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},\n group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},\n last_modified = {2020-09-30T16:35:04.161Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n private_publication = {false},\n abstract = {Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. 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