@article{
 title = {[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of diverse bromodomains},
 type = {article},
 year = {2014},
 pages = {462-476},
 volume = {57},
 websites = {http://pubs.acs.org/doi/abs/10.1021/jm401568s,http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906316/pdf/jm401568s.pdf},
 publisher = {American Chemical Society},
 id = {0762735f-ae86-3d41-8ce3-b731c3207480},
 created = {2015-10-01T17:18:12.000Z},
 file_attached = {true},
 profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},
 last_modified = {2018-09-03T10:20:45.796Z},
 read = {false},
 starred = {true},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Fedorov2014},
 source_type = {Journal Article},
 private_publication = {false},
 abstract = {Bromodomains are gaining increasing interest as drug targets. Commercially sourced and de novo synthesized substituted [1,2,4]triazolo[4,3-a]phthalazines are potent inhibitors of both the BET bromodomains such as BRD4 as well as bromodomains outside the BET family such as BRD9,CECR2,and CREBBP.Thisnew series of compounds is the first example of submicromolar inhibitors of bromodomains outside the BET subfamily. Representative compounds are active in cells exhibiting potent cellular inhibition activity in a FRAP model of CREBBP and chromatin association. The compounds described are valuable starting points for discovery of selective bromodomain inhibitors and inhibitors with mixed bromodomain pharmacology.},
 bibtype = {article},
 author = {Fedorov, Oleg and Lingard, Hannah and Wells, Chris and Monteiro, Octovia P. and Picaud, Sarah and Keates, Tracy and Yapp, Clarence and Philpott, Martin and Martin, Sarah J. and Felletar, Ildiko and Marsden, Brian D. and Filippakopoulos, Panagis and Müller, Susanne and Knapp, Stefan and Brennan, Paul E.},
 doi = {10.1021/jm401568s},
 journal = {Journal of Medicinal Chemistry},
 number = {2}
}

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The compounds described are valuable starting points for discovery of selective bromodomain inhibitors and inhibitors with mixed bromodomain pharmacology.","bibtype":"article","author":"Fedorov, Oleg and Lingard, Hannah and Wells, Chris and Monteiro, Octovia P. and Picaud, Sarah and Keates, Tracy and Yapp, Clarence and Philpott, Martin and Martin, Sarah J. and Felletar, Ildiko and Marsden, Brian D. and Filippakopoulos, Panagis and Müller, Susanne and Knapp, Stefan and Brennan, Paul E.","doi":"10.1021/jm401568s","journal":"Journal of Medicinal Chemistry","number":"2","bibtex":"@article{\n title = {[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of diverse bromodomains},\n type = {article},\n year = {2014},\n pages = {462-476},\n volume = {57},\n websites = {http://pubs.acs.org/doi/abs/10.1021/jm401568s,http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906316/pdf/jm401568s.pdf},\n publisher = {American Chemical Society},\n id = {0762735f-ae86-3d41-8ce3-b731c3207480},\n created = {2015-10-01T17:18:12.000Z},\n file_attached = {true},\n profile_id = {64f7fb50-d000-335d-a02d-06c5f340a97a},\n last_modified = {2018-09-03T10:20:45.796Z},\n read = {false},\n starred = {true},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n citation_key = {Fedorov2014},\n source_type = {Journal Article},\n private_publication = {false},\n abstract = {Bromodomains are gaining increasing interest as drug targets. 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