@article{article2020y,
    author = {Fehlmann, Tobias and Lehallier, Benoit and Schaum, Nicholas and Hahn, Oliver and Kahraman, Mustafa and Li, Yongping and Grammes, Nadja and Geffers, Lars and Backes, Christina and Balling, Rudi and Kern, Fabian and Krüger, Rejko and Lammert, Frank and Ludwig, Nicole and Meder, Benjamin and Fromm, Bastian and Maetzler, Walter and Berg, Daniela and Brockmann, Kathrin and Deuschle, Christian and von Thaler, Anna-Katharina and Eschweiler, Gerhard W. and Milman, Sofiya and Barziliai, Nir and Reichert, Matthias and Wyss-Coray, Tony and Meese, Eckart and Keller, Andreas},
    year = {2020},
    month = {11},
    abstract = "{Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.}",
    title = {Common diseases alter the physiological age-related blood microRNA profile},
    volume = {11},
    journal = {Nature Communications},
    doi = {10.1038/s41467-020-19665-1}
}

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W.","Milman, S.","Barziliai, N.","Reichert, M.","Wyss-Coray, T.","Meese, E.","Keller, A."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Fehlmann"],"firstnames":["Tobias"],"suffixes":[]},{"propositions":[],"lastnames":["Lehallier"],"firstnames":["Benoit"],"suffixes":[]},{"propositions":[],"lastnames":["Schaum"],"firstnames":["Nicholas"],"suffixes":[]},{"propositions":[],"lastnames":["Hahn"],"firstnames":["Oliver"],"suffixes":[]},{"propositions":[],"lastnames":["Kahraman"],"firstnames":["Mustafa"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Yongping"],"suffixes":[]},{"propositions":[],"lastnames":["Grammes"],"firstnames":["Nadja"],"suffixes":[]},{"propositions":[],"lastnames":["Geffers"],"firstnames":["Lars"],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["Christina"],"suffixes":[]},{"propositions":[],"lastnames":["Balling"],"firstnames":["Rudi"],"suffixes":[]},{"propositions":[],"lastnames":["Kern"],"firstnames":["Fabian"],"suffixes":[]},{"propositions":[],"lastnames":["Krüger"],"firstnames":["Rejko"],"suffixes":[]},{"propositions":[],"lastnames":["Lammert"],"firstnames":["Frank"],"suffixes":[]},{"propositions":[],"lastnames":["Ludwig"],"firstnames":["Nicole"],"suffixes":[]},{"propositions":[],"lastnames":["Meder"],"firstnames":["Benjamin"],"suffixes":[]},{"propositions":[],"lastnames":["Fromm"],"firstnames":["Bastian"],"suffixes":[]},{"propositions":[],"lastnames":["Maetzler"],"firstnames":["Walter"],"suffixes":[]},{"propositions":[],"lastnames":["Berg"],"firstnames":["Daniela"],"suffixes":[]},{"propositions":[],"lastnames":["Brockmann"],"firstnames":["Kathrin"],"suffixes":[]},{"propositions":[],"lastnames":["Deuschle"],"firstnames":["Christian"],"suffixes":[]},{"propositions":["von"],"lastnames":["Thaler"],"firstnames":["Anna-Katharina"],"suffixes":[]},{"propositions":[],"lastnames":["Eschweiler"],"firstnames":["Gerhard","W."],"suffixes":[]},{"propositions":[],"lastnames":["Milman"],"firstnames":["Sofiya"],"suffixes":[]},{"propositions":[],"lastnames":["Barziliai"],"firstnames":["Nir"],"suffixes":[]},{"propositions":[],"lastnames":["Reichert"],"firstnames":["Matthias"],"suffixes":[]},{"propositions":[],"lastnames":["Wyss-Coray"],"firstnames":["Tony"],"suffixes":[]},{"propositions":[],"lastnames":["Meese"],"firstnames":["Eckart"],"suffixes":[]},{"propositions":[],"lastnames":["Keller"],"firstnames":["Andreas"],"suffixes":[]}],"year":"2020","month":"11","abstract":"Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.","title":"Common diseases alter the physiological age-related blood microRNA profile","volume":"11","journal":"Nature Communications","doi":"10.1038/s41467-020-19665-1","bibtex":"@article{article2020y,\n author = {Fehlmann, Tobias and Lehallier, Benoit and Schaum, Nicholas and Hahn, Oliver and Kahraman, Mustafa and Li, Yongping and Grammes, Nadja and Geffers, Lars and Backes, Christina and Balling, Rudi and Kern, Fabian and Krüger, Rejko and Lammert, Frank and Ludwig, Nicole and Meder, Benjamin and Fromm, Bastian and Maetzler, Walter and Berg, Daniela and Brockmann, Kathrin and Deuschle, Christian and von Thaler, Anna-Katharina and Eschweiler, Gerhard W. and Milman, Sofiya and Barziliai, Nir and Reichert, Matthias and Wyss-Coray, Tony and Meese, Eckart and Keller, Andreas},\n year = {2020},\n month = {11},\n abstract = \"{Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.}\",\n title = {Common diseases alter the physiological age-related blood microRNA profile},\n volume = {11},\n journal = {Nature Communications},\n doi = {10.1038/s41467-020-19665-1}\n}\n","author_short":["Fehlmann, T.","Lehallier, B.","Schaum, N.","Hahn, O.","Kahraman, M.","Li, Y.","Grammes, N.","Geffers, L.","Backes, C.","Balling, R.","Kern, F.","Krüger, R.","Lammert, F.","Ludwig, N.","Meder, B.","Fromm, B.","Maetzler, W.","Berg, D.","Brockmann, K.","Deuschle, C.","von Thaler, A.","Eschweiler, G. 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